Toll-Like Receptor-1 and Receptor-2 and Beta-Defensin in Postcholecystectomy Bile Duct Injury

CONACYT [SALUD-2005-CO1-13801

[Tumor necrosis factor-alpha and interleukin-6 levels among patients suffering a bile duct injury during cholecystectomy]

BACKGROUND: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL6) to phagocyte toxic products AIM: To measure serum levels of TNF-alpha and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. PATIENTS AND METHODS: Serum levels of TNF-alpha and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. RESULTS: At baseline TNF-alpha levels in healthy subjects and patients with bile duct injury were 0 and 43.9 +/- 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-a became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 +/- 2.0 and 72.0 +/- 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 +/- 0.3 pg/mL among patients. CONCLUSIONS: TNF-alpha and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later

[Tumor necrosis factor-alpha and interleukin-6 levels among patients suffering a bile duct injury during cholecystectomy]

BACKGROUND: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL6) to phagocyte toxic products AIM: To measure serum levels of TNF-alpha and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. PATIENTS AND METHODS: Serum levels of TNF-alpha and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. RESULTS: At baseline TNF-alpha levels in healthy subjects and patients with bile duct injury were 0 and 43.9 +/- 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-a became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 +/- 2.0 and 72.0 +/- 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 +/- 0.3 pg/mL among patients. CONCLUSIONS: TNF-alpha and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later

Modifications in Lipid Levels Are Independent of Serum TNF-alpha in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy

Mexican Institute for Social Security (IMSS) [FIS/IMSS/PROT/028