54 research outputs found

    Aprendizaje servicio y educación superior. Una rúbrica para evaluar la calidad de proyectos

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    [spa] La investigación se plantea estudiar qué aspectos tienen que tener las propuestas de aprendizaje servicio en educación superior para tener una alta calidad y elaborar una herramienta de evaluación para esta calidad adecuada a nuestro contexto. El tema es relevante ya que no se ha profundizado sobre qué supone la calidad en las propuestas de aprendizaje servicio en nuestro contexto y solamente encontraremos referencias norteamericanas. Además facilitar una herramienta a la comunidad educativa puede ayudar a hacer crecer los proyectos y a consolidarlos con mayor calidad. Consideramos que la propuesta de investigación es adecuada en el contexto actual y propone una aportación concreta y de valor para la comunidad educativa. El estudio de los aspectos que dan calidad a una propuesta de aprendizaje servicio nos ha llevado a proponer una herramienta que permite evaluar y reflexionar sobre las propuestas y sus posibles mejoras. Entendemos la evaluación de las propuestas de aprendizaje servicio como un proceso con carácter formativo, como un espacio de reflexión individual y/o grupal y propositiva para la mejora de las propuestas. Hemos planteado un instrumento de evaluación para el profesorado, un instrumento de autoevaluación de la calidad de proyectos de aprendizaje servicio en educación superior que facilite la reflexión sobre la calidad y la mejora de los proyectos ya consolidados o en fase de diseño. Planteamos una rúbrica de autoevaluación de la calidad de proyectos de aprendizaje servicio en educación superior que esté diseñada para ayudar al profesorado a ajustar y mejorar el desarrollo y el enfoque de los proyectos de aprendizaje servicio que estén llevando a cabo o quieran diseñar. La rúbrica está estructurada en diez categorías fruto del análisis de los puntos clave considerados por los expertos como aspectos relevantes de la calidad de los proyectos de aprendizaje servicio en su contexto educativo. La intención es que contestando la rúbrica se lleve a cabo un proceso de reflexión sobre la propia práctica en el que se puedan analizar los distintos componentes. A su vez, se pretende dar ideas y sugerencias para mejorar los proyectos llevándolos a niveles de calidad superiores. La rúbrica deviene así una herramienta de reflexión. Esta rúbrica está planteada como una herramienta de evaluación viva y dinámica, que a través de revisiones, se puede ir modificando. La intención es que el profesorado se sienta cómodo para añadir o modificar categorías. La calidad de los proyectos suele tener un componente de contextualización que el profesorado debería de poder añadir en la rúbrica. Es por esta razón que consideramos la rúbrica como una herramienta abierta.[eng] The research objective is to study the aspects a service learning proposal in a higher education context should possess in order to ensure a high quality outcome and to create a tool to evaluate its outcomes. Besides the establishment of a tool to be used for community education, it can also create growth and consolidate quality amongst existing programs. We have found that the research proposal is up to date with the current environment and demonstrates concrete results and adds value to overall community learning. The study of the aspects that lend quality to service learning proposals have brought us to propose a tool that allows evaluation and reflection concerning the proposals and their areas of improvement. The evaluation of service learning proposals is formative in its nature serving as a space for individual or group reflection and suggestion to improve the proposals. Therefore, the objective is to use a self-evaluating rubric to measure the quality of the service learning proposals in higher education and assist the faculty member make the required adjustments, improve the development and focus of a program that they are managing or creating. The rubric is structured into ten categories based on the analysis of key points experts agree should exist in order to ensure a quality in a service learning program in an educational context. The intention is that by answering, a thinking process about the own exercise gets triggered that allows to analyse all components. The rubric is set up to be dynamic and live, and through revisions can be modified as required. Therefore it can be considered to be open ended in its nature

    Lines of action and principles for the incorporation of service-learning at local level. Networking in the territory

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    This article aims to provide some reflections on the potential of service-learning from a territorial point of view. The construction of educational bets in the local scope through service-learning allows to overcome the development of concrete and isolated experiences and to advance towards the construction of educational networks that have a horizon of common good. The contributions in this sense are based on qualitative experiential research that has combined the documentary analysis of different previous experiences and the action-research process carried out in three Catalan territories (Barcelona, Sant Cugat and Puig-Reig). This text sets out the main lines of action to be developed from the perspective of facilitation and/or coordination in the process of implementing service-learning at a territorial level: approach to the territory, shared diagnosis; generation of projects; and communication of the territorial commitment. The reflection on this process underlines that all of them are based on principles such as openness, recognition, coherence and sustainability, among others. Likewise, the work also points out some reflections about the educational agency by other agents of the territory, beyond the educational centers, and the strengthening of the network work to generate more educational territories.El presente artículo tiene como objetivo aportar algunas reflexiones acerca de la potencialidad del aprendizaje-servicio desde un punto de vista territorial. La construcción de apuestas educativas en el ámbito local a través del aprendizaje-servicio permite superar el desarrollo de experiencias concretas y aisladas y avanzar hacia la construcción de redes educativas que tienen un horizonte de bien común. Los aportes en este sentido parten de una investigación experiencial de corte cualitativo que ha combinado el análisis documental de diferentes experiencias anteriores y el proceso de investigación-acción realizado en tres territorios catalanes (Barcelona, Sant Cugat y Puig-Reig). En este texto se exponen las principales líneas de acción a desarrollar desde la perspectiva de facilitación y/o coordinación en el proceso de implementar el aprendizaje-servicio a nivel territorial: aproximación al territorio, diagnóstico compartido; generación de proyectos; y comunicación de la apuesta territorial. La reflexión acerca de este proceso subraya que todas ellas se sustentan en base a principios como la apertura, el reconocimiento, la coherencia y la sostenibilidad, entre otros. Asimismo, el trabajo también apunta algunas reflexiones acerca de la agencia educativa por parte de otros agentes del territorio, más allá de los centros educativos, y el fortalecimiento del trabajo en red para generar territorios más educadores

    Líneas de acción y principios para la incorporación del aprendizaje-servicio en el ámbito local. Trabajo en red en el territorio

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    El presente artículo tiene como objetivo aportar algunas reflexiones acerca de la potencialidad del aprendizaje-servicio desde un punto de vista territorial. La construcción de apuestas educativas en el ámbito local a través del aprendizaje-servicio permite superar el desarrollo de experiencias concretas y aisladas y avanzar hacia la construcción de redes educativas que tienen un horizonte de bien común. Los aportes en este sentido parten de una investigación experiencial de corte cualitativo que ha combinado el análisis documental de diferentes experiencias anteriores y el proceso de investigación-acción realizado en tres territorios catalanes (Barcelona, Sant Cugat y Puig-Reig). En este texto se exponen las principales líneas de acción a desarrollar desde la perspectiva de facilitación y/o coordinación en el proceso de implementar el aprendizaje-servicio a nivel territorial: aproximación al territorio, diagnóstico compartido; generación de proyectos; y comunicación de la apuesta territorial. La reflexión acerca de este proceso subraya que todas ellas se sustentan en base a principios como la apertura, el reconocimiento, la coherencia y la sostenibilidad, entre otros. Asimismo, el trabajo también apunta algunas reflexiones acerca de la agencia educativa por parte de otros agentes del territorio, más allá de los centros educativos, y el fortalecimiento del trabajo en red para generar territorios más educadores

    ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma

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    Hi ha quatre pàgines de material suplementari sense numeracióExtracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded through the ubiquitin-proteasome system, in a process mediated by the tumor suppressor von Hippel-Lindau (VHL) gene, through a prolyl hydroxylation-dependent mechanism. Our conclusions derive from transient transfection assays in Cos7 cells, as well as the study of endogenous ERK5 in different experimental systems such as MCF7, HMEC, or Caki-2 cell lines. In fact, the specific knockdown of ERK5 in pVHL-negative cell lines promotes a decrease in proliferation and migration, supporting the role of this MAPK in cellular transformation. Furthermore, in a short series of fresh samples from human clear cell renal cell carcinoma, high levels of ERK5 correlate with more aggressive and metastatic stages of the disease. Therefore, our results provide new biochemical data suggesting that ERK5 is a novel target of the tumor suppressor VHL, opening a new field of research on the role of ERK5 in renal carcinomas

    The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

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    Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

    Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

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    Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

    Subclassification of B-acute lymphoblastic leukemia according to age, immunophenotype and microenvironment, predicts MRD risk in Mexican children from vulnerable regions

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    The decisive key to disease-free survival in B-cell precursor acute lymphoblastic leukemia in children, is the combination of diagnostic timeliness and treatment efficacy, guided by accurate patient risk stratification. Implementation of standardized and high-precision diagnostic/prognostic systems is particularly important in the most marginalized geographic areas in Mexico, where high numbers of the pediatric population resides and the highest relapse and early death rates due to acute leukemias are recorded even in those cases diagnosed as standard risk.This work was supported by grants from the National Council of Humanities, Science and Technology (CONAHCYT) FORDECYT-PRONACES 302994 to RP, FORDECYT-PRONACES 302941 to SP-T, and Investigadoras e Investigadores por México CONAHCYT to DC-A.Peer reviewe
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