Sorveglianza delle gastroenteriti da Norovirus in Italia: comparsa e diffusione della nuova variante GII.4 Sydney 2012

In the 2012-2013 winter season, global surveillance for norovirus circulation evidenced the onset of a new norovirus GII.4 variant, termed Sydney 2012. In Italy, ISGEV hospital-based surveillance revealed that this variant already circulated at low frequency in the winter season 2011-2012 and emerged definitively only in the late 2012. This lag-time pattern mirrors the findings reported elsewhere and suggests that the novel variant circulated at low prevalence before spreading globally

Impact Assessment of Energy Storage Systems Supporting DC Railways on AC Power Grids

Energy storage systems (ESSs) represent an established solution for energy saving and voltage regulation in DC urban railway systems. In particular, ESSs can store the braking energy of light rail vehicles (LRVs) and support the DC feeder system during traction operations. Moreover, ESSs can significantly improve the operating conditions of the AC supply system by reducing voltage drops and current spikes. This paper investigates the impact on the bus voltages and branch currents of the AC grid of wayside and on-board ESSs supporting the DC railway infrastructure. An iterative algorithm solves the decoupled AC/DC power flow considering the 3-phase bridge rectifier model of traction substations. The work presents a novel mathematical formulation of the optimization problem to solve the positioning and sizing of supercapacitor-based wayside ESSs, considering both DC and AC network constraints. The effectiveness of the proposed method is proved through numerical simulations on a real Italian DC railway system. Obtained results are presented and discussed comparing the proposed methodology to several existing literature solutions

Host-cell dependent role of phosphorylated keratin 8 during influenza A/NWS/33 virus (H1N1) infection in mammalian cells

In this study, we investigated the involvement of keratin 8 during human influenza A/NWS/33 virus (H1N1) infection in semi-permissive rhesus monkey-kidney (LLC-MK2) and permissive human type II alveolar epithelial (A549) cells. In A549 cells, keratin 8 showed major expression and phosphorylation levels. Influenza A/NWS/33 virus was able to subvert keratin 8 structural organization at late stages of infection in both cell models, promoting keratin 8 phosphorylation in A549 cells at early phases of infection. Accordingly, partial colocalizations of the viral nucleoprotein with keratin 8 and its phosphorylated form were assessed by confocal microscopy at early stages of infection in A549 cells. The employment of chemical activators of phosphorylation resulted in structural changes as well as increased phosphorylation of keratin 8 in both cell models, favoring the influenza A/NWS/33 virus's replicative efficiency in A549 but not in LLC-MK2 cells. In A549 and human larynx epidermoid carcinoma (HEp-2) cells inoculated with respiratory secretions from pediatric patients positive for, respectively, influenza A virus or respiratory syncytial virus, the keratin 8 phosphorylation level had increased only in the case of influenza A virus infection. The results obtained suggest that in A549 cells the influenza virus is able to induce keratin 8 phosphorylation thereby enhancing its replicative efficiency

Role of artificial intelligence in fighting antimicrobial resistance in pediatrics

Artificial intelligence (AI) is a field of science and engineering concerned with the computational understanding of what is commonly called intelligent behavior. AI is extremely useful in many human activities including medicine. The aim of our narrative review is to show the potential role of AI in fighting antimicrobial resistance in pediatric patients. We searched for PubMed articles published from April 2010 to April 2020 containing the keywords “artificial intelligence”, “machine learning”, “antimicrobial resistance”, “antimicrobial stewardship”, “pediatric”, and “children”, and we described the different strategies for the application of AI in these fields. Literature analysis showed that the applications of AI in health care are potentially endless, contributing to a reduction in the development time of new antimicrobial agents, greater diagnostic and therapeutic appropriateness, and, simultaneously, a reduction in costs. Most of the proposed AI solutions for medicine are not intended to replace the doctor’s opinion or expertise, but to provide a useful tool for easing their work. Considering pediatric infectious diseases, AI could play a primary role in fighting antibiotic resistance. In the pediatric field, a greater willingness to invest in this field could help antimicrobial stewardship reach levels of effectiveness that were unthinkable a few years ago

Genetic heterogeneity and recombination in human type 2 astroviruses

Novel lineages of human astrovirus (HAstV) types 2, 2c, and 2d have been identified. Upon sequencing of the 3= end of the genome, the type 2c and 2d HAstVs were found to be open reading frame 1b (ORF1b)-ORF2 recombinant, with ORF1b being derived from type 3 and type 1 HAstVs, respectively. An ORF2 interlineage recombinant strain, 2c/2b, was also identified

Centralized Scheduling Approach to Manage Smart Charging of Electric Vehicles in Smart Cities

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Factor Analysis and the Social Capital Index: A Study at the Brazil / Bolivia Border

Objective: The study aimed to build the level of social capital by neighborhoods Guajará-Mirim border region between the State of Rondônia, Brazil and the Republic of Bolivia, which in recent years has been showing signs of social fragility due advance not virtuous practices. Method: This work made use of research in secondary bases as well as in primary bases. The tabulation of qualitative and quantitative data was performed in Excel (2010) and for their processing performance index construction purposes were calculated following the factorial analysis techniques presented by Hair et al. [19] Santana [20, 21]; and Choi [22]. For this, we made use of the statistical tool SPSS (Statistical Package for Social Sciences) for the construction of the indices of social capital. The correlation analysis process was done in Excel. results: It was observed that the capital reached regular levels in Guajará-Mirim neighborhoods not observable, so correlations between the studied parameters, however, it needs to be further studied as factors such as the flooding of the Mamore river may have interfered in any way in the implementation process of the field survey to the residents of the city. It became clear that the municipality of Guajará-Mirim suffers from serious social problems and that most problems are correlated with the increase in alcoholic beverage market in the city and use drugs. However, was not observed as the institutional arrangements are dealing with this problem, that is, as public bodies are relating to discuss actions for concrete solutions to this evil that plagues large portion of the population of Guajará-Mirim, mainly young teenagers residents of Guajá-Mamim. However, we hope to continue this work in order to better understand this mechanism of social network between the actors of this process in the region