AnálisePsicogenética da Inserção dos Jogos de Regras e das Relações Cooperativas no Ambiente Escolar

Trata-se de um estudo sobre a inserção de jogos de regras na escola como estratégia facilitadora do desenvolvimento de relações cooperativas. De acordo com a abordagem psicogenética, o jogo de regras, ao possibilitar trocas entre iguais baseadas na reciprocidade, acaba por favorecer a cooperação. Buscou-se, então, analisar no cotidiano de duas escolas (uma reconhecidamente construtivista e a outra com métodos de ensino ditos tradicionais) as configurações dadas ao jogo de regras e suas possíveis contribuições para a evolução das trocas cooperativas das crianças. Na primeira etapa da coleta dos dados utilizou-se um roteiro de entrevista para os profissionais pedagógicos e um protocolo de observação. Tais instrumentos destinaram-se à caracterização das escolas em termos da utilização de jogos de regras. Em uma segunda etapa foi utilizado um roteiro de entrevista para a investigação de aspectos relacionados à tendência cooperativa dos alunos. Os dados foram sistematizados de forma descritiva, contando vez ou outra com categorizações e buscando compreender em seu conteúdo análises quantitativas e qualitativas. Os resultados demonstraram que a maior presença dos jogos de regras no contexto da escola construtivista foi acompanhada por um maior desempenho cooperativo de seus alunos

Proposal of a New Standardized Freeze-Thawing Technical Protocol for Leucocyte-Poor Platelet-Rich Plasma Preparation and Cryopreservation

A human platelet-rich plasma (PRP) concentrate can be defined as a preparation of autologous human plasma with increased platelet concentration produced by centrifugation of a larger volume of a patient's own blood. Platelets contain a plethora of growth factors in their α-granules that are concentrated through the centrifugation process in order to then be injected in supraphysiologic amounts to an injury site with the final aim of augmenting the natural healing process. Preparations of PRP concentrates can be further classified as leucocyte-rich (LR-PRP), defined as having a leucocyte concentration above baseline, and leucocyte-poor (LP-PRP), defined as having a leucocyte concentration below baseline. Although many preclinical and clinical trials have shown the ability of leucocyte-poor PRP concentrates to significantly improve symptomatic mild to moderate hip and/or knee osteoarthritis, to date there is no consensus on the optimal way of obtaining PRP preparations, specifically with respect to the concentration of blood components. In this technical report, we describe a new standardized freeze-thawing technique for leucocyte-poor PRP preparation and cryopreservation, which has been shown to be superior to currently available techniques based solely on centrifugation. By describing this technical protocol, which we have been using on a daily basis in the setting of a Regenerative Medicine Outpatient Clinic in a European tertiary university hospital center, we aim to contribute to a future consensus on the optimal way of obtaining and preserving leucocyte-poor PRP concentrates.info:eu-repo/semantics/publishedVersio

Professores universitários com deficiência: trajetória escolar e conquista profissional

Este estudo tem como foco a educação escolar de pessoas com deficiência. Investigou-se a trajetória escolar de professores universitários, com o objetivo de compreender influências sobre desempenho escolar e identificar razões da distinção que os tornou minoria dentre os milhares de outras pessoas com deficiência que não atingem tal patamar de educação formal e profissionalização. O estudo tem como base teórica os trabalhos de Bourdieu. Optou-se por trabalhar com procedimentos metodológicos de entrevista, questionário e análise de documentos biográficos. Participaram desta pesquisa três professores. O estudo indica que a valorização familiar pelo estudo, a condescendência da instituição escolar e a distribuição do capital cultural objetivado são indicativos do desempenho escolar e profissional destes sujeitos

Endothelial progenitor cells and integrins: adhesive needs

In the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent

Medical Residency´ Satisfaction in Portugal

INTRODUCTION: In the last years, the global context of medical education and Medical Residency programs in Portugal suffered substantial changes. The primary objective of this study was to evaluate and characterize medical residents ́ satisfaction with medical residency programs in Portugal and to identify features that could be improved. MATERIAL AND METHODS: We utilized as model the survey Postgraduate Hospital Educational Environment Measure that has been developed in the United Kingdom and is speci cally targeted to medical residents. The survey was translated and adapted to the Portuguese reality. The survey was available online during April and May of 2016. RESULTS: A total of 3456 responses were obtained, corresponding to a response rate of 35%. Endocrinology/Nutrition, Cardiology, Anesthesiology, Family Physician and Gastroenterology were the specialties in which the degree of satisfaction was higher, while Forensic Medicine, Medical Oncology, Internal Medicine, General Surgery and Pneumology showed the lowest level of satisfaction. DISCUSSION: This study presented a high response rate when compared to previous studies. Portuguese medical residents presented high levels of satisfaction. Depending on year of medical residency, region, type of specialty and type of hospital marked asymmetries were noticed. CONCLUSION: The survey ́s results should constitute in the future a support tool for the implementation of local and national measures relating to the medical residency. It is advisable to regularly conduct satisfaction surveys to medical residents.info:eu-repo/semantics/publishedVersio