The effect of manganese oxide on the sinterability of hydroxyapatite

The sinterability of manganese oxide (MnO2) doped hydroxyapatite (HA) ranging from 0.05 to 1 wt% was investigated. Green samples were prepared and sintered in air at temperatures ranging from 1000 to 1400 °C. Sintered bodies were characterized to determine the phase stability, grain size, bulk density, hardness, fracture toughness and Young's modulus. XRD analysis revealed that the HA phase stability was not disrupted throughout the sintering regime employed. In general, samples containing less than 0.5 wt% MnO2 and when sintered at lower temperatures exhibited higher mechanical properties than the undoped HA. The study revealed that all the MnO2-doped HA achieved >99% relative density when sintered at 1100–1250 °C as compared to the undoped HA which could only attained highest value of 98.9% at 1150 °C. The addition of 0.05 wt% MnO2 was found to be most beneficial as the samples exhibited the highest hardness of 7.58 GPa and fracture toughness of 1.65 MPam1/2 as compared to 5.72 GPa and 1.22 MPam1/2 for the undoped HA when sintered at 1000 °C. Additionally, it was found that the MnO2-doped samples attained E values above 110 GPa when sintered at temperature as low as 1000 °C if compared to 1050 °C for the undoped HA

Observation of ferromagnetic resonance in strontium ruthenate (SrRuO3)

We report the observation of ferromagnetic resonance (FMR) in SrRuO3 using the time-resolved magneto-optical Kerr effect. The FMR oscillations in the time-domain appear in response to a sudden, optically induced change in the direction of easy-axis anistropy. The high FMR frequency, 250 GHz, and large Gilbert damping parameter, alpha ~ 1, are consistent with strong spin-orbit coupling. We find that the parameters associated with the magnetization dynamics, including alpha, have a non-monotonic temperature dependence, suggestive of a link to the anomalous Hall effect.Comment: submitted to Phys. Rev. Let

DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC)

Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and none assessing its relationship with lifestyle exposures. Aims & Methods: To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor - 1) and N-33 (tumour suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. Sixty eight subjects were recruited (24 UC and 44 age and sex matched controls). Colorectal mucosal biopsies were obtained and DNA was extracted. Genomic DNA methylation was quantified using the tritium-labelled cytosine extension assay (3[H] dCTP) whilst gene specific methylation was quantified using the COBRA method. Results: The methylation level of both ESR-1 and N-33 genes were significantly higher in UC subjects compared with controls (7.9% vs 5.9%; p = 0.015 and 66% vs 9.3%; p < 0.001 respectively). There was no detectable difference in global DNA methylation between patients with UC and age and sex matched controls. No associations between indices of DNA methylation and anthropometric measures or smoking patterns were detected. Conclusions: For the first time, we have shown increased methylation in the promoter regions of the putative tumour suppressor gene N-33 in macroscopically normal mucosa of patients with UC. In addition, we have confirmed that methylation of ESR-1 promoter is higher in UC patients compared with age and sex matched controls. These findings suggests that, inactivation through methylation of the putative tumour suppressor genes N-33 and ESR-1, may not be associated with colorectal carcinogenesis in UC

X-ray Line Diagnostics of Hot Accretion Flows around Black Holes

We compute X-ray emission lines from thermal plasma in hot accretion flows. We show that line profiles are strong probes of the gas dynamics, and we present line-ratio diagnostics which are sensitive to the distribution of mass with temperature in the flow. We show how these can be used to constrain the run of density with radius, and the size of the hot region. We also present diagnostics which are primarily sensitive to the importance of recombination versus collisional ionization, and which could help discriminate ADAFs from photoionization-dominated accretion disk coronae. We apply our results to the Galactic center source Sagittarius A* and to the nucleus of M87. We find that the brightest predicted lines are within the detection capability of current $X$-ray instruments.Comment: 16 pages, 1 table, 9 figures, accepted to Ap

Gamma-ray Emission From Advection-Dominated Accretion Flows Around Black Holes: Application to the Galactic Center

We calculate the flux and spectrum of \gamma-rays emitted by a two-temperature advection-dominated accretion flow (ADAF) around a black hole. The \gamma-rays are from the decay of neutral pions produced through proton-proton collisions. We discuss both thermal and power-law distributions of proton energies and show that the \gamma-ray spectra in the two cases are very different. We apply the calculations to the \gamma-ray source, 2EG J1746-2852, detected by EGRET from the direction of the Galactic Center. We show that the flux and spectrum of this source are consistent with emission from an ADAF around the supermassive accreting black hole Sgr A^* if the proton distribution is a power-law. The model uses accretion parameters within the range made likely by other considerations. If this model is correct, it provides evidence for the presence of a two temperature plasma in Sgr A^*, and predicts \gamma-ray fluxes from other accreting black holes which could be observed with more sensitive detectors.Comment: 19 pages (Latex), 4 Figures. ApJ 486. Revised Tables and Figure

Theoretical analysis of perching and hovering maneuvers

Unsteady aerodynamic phenomena are encountered in a large number of modern aerospace and non-aerospace applications. Leading edge vortices (LEVs) are of particular interest because of their large impact on the forces and performance. In rotorcraft applications, they cause large vibrations and torsional loads (dynamic stall), affecting the performance adversely. In insect flight however, they contribute positively by enabling high-lift flight. Identifying the conditions that result in LEV formation and modeling their effects on the flow is an important ongoing challenge. Perching (airfoil decelerates to rest) and hovering (zero freestream velocity) maneuvers are of special interest. In earlier work by the authors, a Leading Edge Suction Parameter (LESP) was developed to predict LEV formation for airfoils undergoing arbitrary variation in pitch and plunge at a constant freestream velocity. In this research, the LESP criterion is extended to situations where the freestream velocity is varying or zero. A point-vortex model based on this criterion is developed and results from the model are compared against those from a computational fluid dynamics (CFD) method. Abstractions of perching and hovering maneuvers are used to validate the low-order model's performance in highly unsteady vortex-dominated flows, where the time-varying freestream/translational velocity is small in magnitude compared to the other contributions to the velocity experienced by the leading edge region of the airfoil. Time instants of LEV formation, flow topologies and force coefficient histories for the various motion kinematics from the low-order model and CFD are obtained and compared. The LESP criterion is seen to be successful in predicting the start of LEV formation and the point-vortex method is effective in modeling the flow development and forces on the airfoil. Typical run-times for the low-order method are between 30-40 seconds, making it a potentially convenient tool for control/design applications