A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population

BACKGROUND: To investigate the clinicopathological characteristics and the survival outcomes of invasive lobular carcinoma (ILC) patients compared to invasive ductal carcinoma (IDC) patients according to their molecular subtype. METHODS: We compared the clinicopathological characteristics, breast cancer-specific survival (BCSS) and overall survival (OS) between patients with IDC (n = 14,547) and ILC (n = 528). RESULTS: The ILC presented with a larger tumor size, more advanced cancer stage, increased rate of hormonal receptor positivity, human epidermal growth factor 2 (HER2) negativity and mastectomy than the IDC. The ILC patients more frequently presented with the luminal A subtype, whereas the IDC patients more frequently presented with the luminal B, HER2-overexpression, or triple negative subtype. The BCSS and OS were not significantly different between the IDC and ILC for each molecular subtype. CONCLUSIONS: Similar to IDC patients, molecular subtype should be considered when determining the prognosis and treatment regimen for ILC patients

ANASYSIS OF ISOMETRICITY OF THE ANTERIOR CRUCIATE LIGAMENT DURING KNEE FLEXION-EXTENSION FOR OPTIMAL LIGAMENT RECONSTRUCTION

Anterior cruciate ligament (ACL) is liable to a major injury that often results in a functional impairment requiring surgical reconstruction. The success of reconstruction depends on such factors as attachment positions, initial tension of ligament and surgical methods of fixation. The purpose of this study is to find isometric area of the substitute during flexion/extension and to simulate successful ACL reconstruction position using MADYMO(MAthematical DYnamic MOdel) software

Characterization of GDP-mannose Pyrophosphorylase from Escherichia Coli O157:H7 EDL933 and Its Broad Substrate Specificity

GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed very broad substrate specificities for four nucleotides and various hexose-1-phosphates, yielding ADP-mannose, CDP-mannose, UDP-mannose, GDP-mannose, GDP-glucose and GDP-2-deoxy-glucose

Analysis of Platforms and Functions of Mobile-Based Personal Health Record Systems

ObjectivesLittle is known about the platforms and functionalities of mobile-based personal health record (PHR) applications. The objective of this study was to investigate these two features of PHR systems.MethodsThe unit of analysis was general hospitals with more than 100 beds. This study was based on a PHR survey conducted from May 1 to June 30, 2020 and the National Health Insurance administrative data as of March 31, 2020. The study considered the platform, Android and iPhone operation system (iOS), and types of functionalities of PHR systems. Among the 316 target hospitals, 103 hospitals had adopted PHR systems. A logistic regression analysis was used.ResultsThis study found that 103 hospitals had adopted mobile-based PHR systems for their patients. Sixty-four hospitals (62.1%) were adopting both Android and iOS, but 36 (35.0%) and 3 (2.9%) hospitals were adopting Android only or iOS only, respectively. The PHR systems of hospitals adopting both platforms were more likely to have functions for viewing prescriptions, clinical diagnostic test results, and upcoming appointment status compared to those adopting a single platform (p \u3c 0.001). The number of beds (odds ratio [OR] = 1.004; confidence interval [CI], 1.001–1.007; p = 0.0029) and the number of computed tomography systems (CTs) per 100 beds (OR = 6.350; CI, 1.006–40.084; p = 0.0493) were significantly associated with the adoption of both platforms.ConclusionsMore than 60% of hospitals had adopted both Android and iOS platforms for their patients in Korea. Hospitals adopting both platforms had additional functionalities and significant association with the number of beds and CTs

GAIT ANALYSIS OF THE NORMAL AND ACL DEFICIENT PATIENTS AFTER LIGAMENT RECONSTRUCTION SURGERY

Anterior cruciate ligament (ACL) injury of the knee is common in sports. A serious ACL injury leads to ligament reconstruction surgery. In order to evaluate result of surgery or optimize the rehabilitation process, a knee condition must be objectively identified. The purpose of this study is, therefore, to numerically indicate and classify knee condition of patients via the chaos analysis. Lyapunov exponents (LyEs) were used for the comparison of the normal and the patients

Application of Recycled Zero-Valent Iron Nanoparticle to the Treatment of Wastewater Containing Nitrobenzene

Zero-valent iron (ZVI) was synthesized using iron oxide, a byproduct of pickling line at a steel work. ZVI with a mean particle size of 500 nm was synthesized. The reaction activity of the synthesized ZVI was much higher than commercial ZVI. When applied to the decomposition of nitrobenzene (NB), the ZVI particles underwent corrosion and passivation oxide film formation, resulting in particle size decrease. The NB decomposition rate increased with increasing ZVI dosage level and with decreasing pH. The solution pH increased monotonously with increasing reaction duration, whereas the aniline concentration showed a maximum at 50 min. Based on the GC/MS analysis, NB is presumed to be reduced into aniline via reductive intermediates such as azobenzene and azoxybenzene. When combined with a subsequent biological process, the synthesized ZVI will be able to decompose NB in wastewater effectively

Thermal Effects of Microwave Reduced-Graphene-Oxide Coated Polyester Fabric on a Simulated Human Skin in Cool and Neutral Air Temperatures

Batteryless wearable technology has wide applications. In particular, human body surface temperature controlling fabrics can help regulate skin temperature in heat or cold. This study investigated surface temperature distribution of the fabrics coated with reduced graphene oxide (rGO) on simulated human body skin conditions at 18 degrees C (cool) and 27 degrees C (neutral) ambient air temperatures. Polyester fabrics were spin-coated with a graphene-oxide (GO) solution of 0.2 wt%. Preparation of rGO was processed by using a microwave oven (MW-rGO). Non-treated fabric (CON) was compared to GO and MW-rGO. The surface temperature of a hot plate was maintained at 35 degrees C or 40 degrees C. The test fabrics were put on the heated hot plate or non-heated-outer portions of the hot plate. Surface temperatures of MW-rGO on the heated hot plate at an air temperature of 18 degrees C (cool) were higher than those of non-treated fabric (CON) under the same conditions (p < 0.01). No effects from the graphene treatment were found on non-heated portions of the graphene oxide fabric (GO) or the reduced graphene oxide fabric (MW-rGO). On the non-heated portions, surface temperatures were higher at the location closer to the hot plate compared to the location farther from the hot plate (p < 0.05). These results partially represent thermal effects of MW-rGO under a specific environment and heat source. Our findings enable an application of reduced graphene oxide to body temperature regulating clothing.