Antireflux Transoral Incisionless Fundoplication Using EsophyX: 12-Month Results of a Prospective Multicenter Study

BACKGROUND: A novel transoral incisionless fundoplication (TIF) procedure using the EsophyX system with SerosaFuse fasteners was designed to reconstruct a full-thickness valve at the gastroesophageal junction through tailored delivery of multiple fasteners during a single-device insertion. The safety and efficacy of TIF for treating gastroesophageal reflux disease (GERD) were evaluated in a prospective multicenter trial. METHODS: Patients (n = 86) with chronic GERD treated with proton pump inhibitors (PPIs) were enrolled. Exclusion criteria included an irreducible hiatal hernia > 2 cm. RESULTS: The TIF procedure (n = 84) reduced all hiatal hernias (n = 49) and constructed valves measuring 4 cm (2-6 cm) and 230 degrees (160 degrees -300 degrees ). Serious adverse events consisted of two esophageal perforations upon device insertion and one case of postoperative intraluminal bleeding. Other adverse events were mild and transient. At 12 months, aggregate (n = 79) and stratified Hill grade I tight (n = 21) results showed 73% and 86% of patients with >or=50% improvement in GERD health-related quality of life (HRQL) scores, 85% discontinuation of daily PPI use, and 81% complete cessation of PPIs; 37% and 48% normalization of esophageal acid exposure; 60% and 89% hiatal hernia reduction; and 62% and 80% esophagitis reduction, respectively. More than 50% of patients with Hill grade I tight valves had a normalized cardia circumference. Resting pressure of the lower esophageal sphincter (LES) was improved significantly (p < 0.001), by 53%. EsophyX-TIF cured GERD in 56% of patients based on their symptom reduction and PPI discontinuation. CONCLUSION: The 12-month results showed that EsophyX-TIF was safe and effective in improving quality of life and for reducing symptoms, PPI use, hiatal hernia, and esophagitis, as well as increasing the LES resting pressure and normalizing esophageal pH and cardia circumference in chronic GERD patients.Journal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Endoscopic palliative intubation of inoperable malignant esophagogastric obstruction

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Colorectal cancer and dietary calcium: a word of hope.

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Primary prevention of colorectal cancer

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Economic impact of a colorectal cancer screening programme in Belgium

SCOPUS: cp.jinfo:eu-repo/semantics/publishe

Endoscopic palliation of malignant dysphagia

SCOPUS: cp.jinfo:eu-repo/semantics/publishe

Nd-YAG laser, a new palliative alternative in the management of esophageal cancer

Ten patients with unresectable esophageal malignant tumor have been managed by Nd-YAG laser palliative therapy. Esophageal obstruction, and dysphagia, the most frequent symptoms, were relieved in all cases after periods ranging from 5 to 14 days. The mean total energy required was 26.121 watts sec-1. No serious immediate or late complication was encountered, except for one small transient bleeding without clinical repercussion. Two relapses of dysphagia were successfully managed by the same procedure. This new palliative approach has to be compared with the other available methods, surgical resection and bypass procedures, radiotherapy or endoscopic prosthetic intubation. Its high degree of effectiveness in providing rapid relief of dysphagia, and its low morbidity rate will give to laser therapy an important place in the future palliative management of esophageal cancer, either alone or in combination with other treatments.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Le pyrosis: Reflux gastro-œsophagien en 9 tableaux

This article summarises the conference which took place during the " Centre Universitaire de Médecine Générale de l'Université Libre de Bruxelles " (C.U.M.G.-U.L.B.) Seminar in April 7-14, 2007. It is in no way an extensive review about gastro-oesophageal reflux disease (GERD), but instead an attempt of answering the most frequently asked questions by the general practitioner, reported in 9 pictures :1. Definition, prevalence and physiopathology. 2. Work up and role of endoscopy. 3. Medical treatment. 4. PPI :Equivalence of the medications ?Equivalence of the generic drugs ?5. Barrett's esophagus. 6. Reflux and negative endoscopy. 7. Extra-oesophageal manifestations. 8. Surgical treatments. 9. Endoscopic treatments.SCOPUS: cp.jinfo:eu-repo/semantics/publishe

OESOPHAGE DE BARRETT. CARACTERISATION ET POLITIQUE DE SURVEILLANCE

SCOPUS: cp.jinfo:eu-repo/semantics/publishe

Calculs biliaires et pancréatite chronique: traitement par sphinctérotomie endoscopique

SCOPUS: cp.jinfo:eu-repo/semantics/publishe