Transfer bond stresses generated between FRP tendons and concrete

There is a growing interest in the use of new materials in construction. Materials such as fibre-reinforced plastics (FRPs) are lightweight, strong, and, for the most part, non-corrodible. Hence, the use of FRPs as prestressing tendons for concrete represents a viable, durable alternative to conventional practice using prestressing steel. This paper addresses the nature of the bond between an FRP tendon and concrete in the transfer zone of a pretensions concrete beam. In particular, two different types of aramid fibre-reinforced plastics (AFRPs) are considers. In the experimental investigation, the tendon pull-in behaviour during detensioning of a number of small-scale (100 X 200 X 2800 mm) pretensions concrete beams was monitored. These results were then used to make inferences about the bond stress distribution through the transfer zone. Both a constant and a non-linear relationship between the bond shear stress and the tendon slip were considers and the transfer behaviour of the two types of AFRP and steel were compared. It was found that by assuming a non-uniform bond stress distribution some interesting results about the distinctly different natures of the bond behaviour of the three materials were obtained. Teijin Ltd., Mitsui Construction Co., Natural Sciences and Engineering Research Council of Canada

Expansive cement couplers - a means of pre-tensioning fibre reinforced plastic tendons

Fibre reinforced plastics describes a group of materials composed of inorganic or organic fibres embedded in a resin matrix. frps are strong, non-magnetic, light-weight and for the most part, non-corrodable. There is great scope for the use of frps as concrete reinforcement and the high strength of the materials is conducive to prestressed applications. However, finding a suitable method of anchoring the tendons without inducing stress concentrations in the fibres has been identified as a problem. The current paper investigates the potential for the use of expansive cement couplers as a means of pretensioning frp tendons. An experimental study was carried out on couplers to join steel reinforcing bars and then extended to include the coupling of frp materials to steel prestress wire

Analysis of concrete beams with partially bonded composite reinforcement

Beams prestressed with partially bonded fiber-reinforced plastic (FRP) tendons have high strength and rotation capacity but cannot be modeled by conventional techniques. Herein, it is assumed that all deformation takes place at cracks between rigid bodies. By setting up appropriate compatibility and equilibrium equations, the behavior at a single crack can be modeled, which then allows predictions to be made as to which of four possible events will occur next. These lead either to beam failure, or to changes in the geometry that can be analyzed using the same techniques. Comparisons are made with test results, and reasonable agreement is shown.http://www.concrete.org/PUBS/JOURNALS/AbstractDetails.asp?ID=85

Experimental Study of the Influence of Bond on the Flexural Behaviour of Concrete Beams Pre-tensioned with AFRPs

This is the accepted version of the original publication available at http://www.concrete.org/Publications/ACIMaterialsJournal/ACIJournalSearch.aspx?m=details&ID=671An experimental program was formulated to investigate the flexural behaviour of concrete prestressed with aramid fibre reinforced plastic tendons (AFRPs). The particular focus was the influence of the bond between an AFRP tendon and concrete on the flexural response of a beam. In the main test series pre-tensioned concrete beams were cast using either one of two types of AFRP tendons or steel tendons. The influence of bond was studied by testing beams with fully-bonded tendons, unbonded tendons or partially-bonded tendons. It was found that, although the fully-bonded beams had a high ultimate load capacity, only limited rotation occurred prior to failure. In contrast, large rotations were noted in the unbonded beams but the strengths of these members were significantly (25%) lower than those of the fully-bonded beams. The only beams that achieved both a high rotation capacity and a high ultimate load capacity were the beams with partially-bonded tendons. It is suggested that the use of partially-bonded tendons could provide the basis of a new design method for concrete beams prestressed with FRPs

Neighbourhood perceptions of physical activity: a qualitative study

Background: Effective promotion of physical activity in low income communities is essential given the high prevalence of inactivity in this sector. Methods: This study explored determinants of engaging in physical activity in two Irish city based neighbourhoods using a series of six focus groups and twenty five interviews with adult residents. Data were analysed using constant comparison methods with a grounded theory approach. Results: Study findings centred on the concept of 'community contentment'. Physical activity was related to the degree of contentment/comfort within the 'self' and how the 'self' interacts within the neighbourhood. Contemporary focus on outer bodily appearance and pressure to comply with societal expectations influenced participants' sense of confidence and competence. Social interaction, involvement, and provision of adequate social supports were viewed as positive and motivating. However normative expectations appeared to affect participants' ability to engage in physical activity, which may reflect the 'close knit' culture of the study neighbourhoods. Access to suitable local facilities and amenities such as structured and pleasant walking routes was regarded as essential. Indeed participants considered walking to be their preferred form of physical activity which may relate to the minimal skill requirement, ease of access and low financial costs incurred. Conclusion: In the context of physical activity, health promoters need to be conscious of the difficulties that individuals feel in relation to bodily appearance and the pressure to comply with societal standards. This may be particularly relevant in low income settings where insufficient allocation of resources and social supports means that individuals have less opportunity to attend to physical activity than individuals living in higher income settings

Therapeutic Benefit of Radial Optic Neurotomy in a Rat Model of Glaucoma

Radial optic neurotomy (RON) has been proposed as a surgical treatment to alleviate the neurovascular compression and to improve the venous outflow in patients with central retinal vein occlusion. Glaucoma is characterized by specific visual field defects due to the loss of retinal ganglion cells and damage to the optic nerve head (ONH). One of the clinical hallmarks of glaucomatous neuropathy is the excavation of the ONH. The aim of this work was to analyze the effect of RON in an experimental model of glaucoma in rats induced by intracameral injections of chondroitin sulfate (CS). For this purpose, Wistar rats were bilaterally injected with vehicle or CS in the eye anterior chamber, once a week, for 10 weeks. At 3 or 6 weeks of a treatment with vehicle or CS, RON was performed by a single incision in the edge of the neuro-retinal ring at the nasal hemisphere of the optic disk in one eye, while the contralateral eye was submitted to a sham procedure. Electroretinograms (ERGs) were registered under scotopic conditions and visual evoked potentials (VEPs) were registered with skull-implanted electrodes. Retinal and optic nerve morphology was examined by optical microscopy. RON did not affect the ocular hypertension induced by CS. In eyes injected with CS, a significant decrease of retinal (ERG a- and b-wave amplitude) and visual pathway (VEP N2-P2 component amplitude) function was observed, whereas RON reduced these functional alterations in hypertensive eyes. Moreover, a significant loss of cells in the ganglion cell layer, and Thy-1-, NeuN- and Brn3a- positive cells was observed in eyes injected with CS, whereas RON significantly preserved these parameters. In addition, RON preserved the optic nerve structure in eyes with chronic ocular hypertension. These results indicate that RON reduces functional and histological alterations induced by experimental chronic ocular hypertension

Undergraduate medical research: the student perspective

Background: Research training is essential in a modern undergraduate medical curriculum. Our evaluation aimed to (a) gauge students’ awareness of research activities, (b) compare students’ perceptions of their transferable and research-specific skills competencies, (c) determine students’ motivation for research and (d) obtain students’ personal views on doing research. Methods: Undergraduate medical students (N=317) completed a research skills questionnaire developed by the Centre for Excellence in Teaching and Learning in Applied Undergraduate Research Skills (CETL-AURS) at Reading University. The questionnaire assessed students’ transferable skills, research-specific skills (e.g., study design, data collection and data analysis), research experience and attitude and motivation towards doing research. Results: The majority of students are motivated to pursue research. Graduate entrants and male students appear to be the most confident regarding their research skills competencies. Although all students recognise the role of research in medical practice, many are unaware of the medical research activities or successes within their university. Of those who report no interest in a career incorporating research, a common perception was that researchers are isolated from patients and clinical practice. Discussion: Students have a narrow definition of research and what it entails. An explanation for why research competence does not align more closely with research motivation is derived from students’ lack of understanding of the concept of translational research, as well as a lack of awareness of the research activity being undertaken by their teachers and mentors. We plan to address this with specific research awareness initiatives

Error-Prone ZW Pairing and No Evidence for Meiotic Sex Chromosome Inactivation in the Chicken Germ Line

In the male mouse the X and Y chromosomes pair and recombine within the small pseudoautosomal region. Genes located on the unsynapsed segments of the X and Y are transcriptionally silenced at pachytene by Meiotic Sex Chromosome Inactivation (MSCI). The degree to which MSCI is conserved in other vertebrates is currently unclear. In the female chicken the ZW bivalent is thought to undergo a transient phase of full synapsis at pachytene, starting from the homologous ends and spreading through the heterologous regions. It has been proposed that the repair of the ZW DNA double-strand breaks (DSBs) is postponed until diplotene and that the ZW bivalent is subject to MSCI, which is independent of its synaptic status. Here we present a distinct model of meiotic pairing and silencing of the ZW pair during chicken oogenesis. We show that, in most oocytes, DNA DSB foci on the ZW are resolved by the end of pachytene and that the ZW desynapses in broad synchrony with the autosomes. We unexpectedly find that ZW pairing is highly error prone, with many oocytes failing to engage in ZW synapsis and crossover formation. Oocytes with unsynapsed Z and W chromosomes nevertheless progress to the diplotene stage, suggesting that a checkpoint does not operate during pachytene in the chicken germ line. Using a combination of epigenetic profiling and RNA–FISH analysis, we find no evidence for MSCI, associated with neither the asynaptic ZW, as described in mammals, nor the synaptic ZW. The lack of conservation of MSCI in the chicken reopens the debate about the evolution of MSCI and its driving forces

Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells

The mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins (p16Ink4a and p19Arf) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53 transcription factor in response to oncogenic stress. Although p19Arf is not normally detected in tissues of young adult mice, a notable exception occurs in the male germ line, where Arf is expressed in spermatogonia, but not in meiotic spermatocytes arising from them. Unlike other contexts in which the induction of Arf potently inhibits cell proliferation, expression of p19Arf in spermatogonia does not interfere with mitotic cell division. Instead, inactivation of Arf triggers germ cell-autonomous, p53-dependent apoptosis of primary spermatocytes in late meiotic prophase, resulting in reduced sperm production. Arf deficiency also causes premature, elevated, and persistent accumulation of the phosphorylated histone variant H2AX, reduces numbers of chromosome-associated complexes of Rad51 and Dmc1 recombinases during meiotic prophase, and yields incompletely synapsed autosomes during pachynema. Inactivation of Ink4a increases the fraction of spermatogonia in S-phase and restores sperm numbers in Ink4a-Arf doubly deficient mice but does not abrogate γ-H2AX accumulation in spermatocytes or p53-dependent apoptosis resulting from Arf inactivation. Thus, as opposed to its canonical role as a tumor suppressor in inducing p53-dependent senescence or apoptosis, Arf expression in spermatogonia instead initiates a salutary feed-forward program that prevents p53-dependent apoptosis, contributing to the survival of meiotic male germ cells