Commentary : Fatty acids, breastfeeding and Autism Spectrum Disorder

Fatty acid deficiencies are linked to Autism Spectrum Disorder. This commentary discusses the protective role of breastfeeding and the urgency of research into the human infant\u27s intake of colostrum to prevent fatty acid deficiency

The Public Good, Bad Policies, and Tough Times: When Profit and Public Interests Collide

Privatization of public goods maximizes corporate profits while providing minimal benefits or protections to public health. When calamities such as infectious disease pandemics, natural disasters, and severe weather strike, privatized systems often fail to respond adequately. This issue brief describes how privatization of public goods undermines public health, damages public trust, and erodes democracy and provides suggestions for how we can rethink policies to value people over profits instead of valuing profits over people

Recovery-informed Theory: Situating the Subjective in the Science of Substance Use Disorder Recovery

As recovery from substance use disorder becomes more than a mere quantifiable outcome, there exists a need to discuss and propose the underlying theoretical constructs that ultimately describe and identify the science of recovery. In this abstract undertaking, we propose an initial formulation of a grand theory of recovery science, built upon the seminal theories of recovery capital, recovery-oriented systems of care, and socioecological theory. This grand theory - labeled recovery-informed theory (RIT) - states that successful long-term recovery is self-evident and is a fundamentally emancipatory set of processes. This paper will discuss, analyze, and explore this theory as it is situated within the larger substance use, misuse, and disorder contexts. The uses, implications, and benefits of RIT as an organizing point of inquiry for recovery science are also discussed. By promoting the role of subjective recovery experience in the formulation of the study of recovery, it may be possible to summon new ideas, metrics, and strategies that can directly address substance use disorders in society. Adopting a recovery-informed understanding as follows from this grand theory may allow individual recovery and wellness trajectories to be explored, adapted, and modified to exemplify person-centered and individualized recovery strategies

Where do we come from, where are we now, and where are we going? The Evolution of Collegiate Recovery Science

Attendees will be provided with a brief history/timeline of collegiate recovery as a field, through the lens of research (with a focus on the explosive growth in knowledge in the last decade). This initial presentation will be followed by a synopsis of the current state of collegiate recovery science, focusing on recent studies in the field (CRP alumni survey; meta-reviews; and any large impact studies published in the last year up to month of the conference). The session will end with a presentation on the directions for the future, making clear calls that not only does the research need to continue and in what suggested ways, but also serving to inspire students to engage in the process as they are our best hope to continue the work in innovative ways we haven't thought of. The current landscape of collegiate recovery research and recovery science overall. Additionally, attendees will be able to describe future directions for this type of inquiry. &nbsp

Do Hadronic Charge Exchange Reactions Measure Electroweak L = 1 Strength?

An eikonal model has been used to assess the relationship between calculated strengths for first forbidden beta decay and calculated cross sections for (p,n) charge exchange reactions. It is found that these are proportional for strong transitions, suggesting that hadronic charge exchange reactions may be useful in determining the spin-dipole matrix elements for astrophysically interesting leptonic transitions.Comment: 14 pages, 5 figures, Submitted to Physical Review

Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade

MEC-4 and MEC-10 are the pore-forming subunits of the sensory mechanotransduction complex that mediates touch sensation in Caenorhabditis elegans (O'Hagan, R., M. Chalfie, and M.B. Goodman. 2005. Nat. Neurosci. 8:43–50). They are members of a large family of ion channel proteins, collectively termed DEG/ENaCs, which are expressed in epithelial cells and neurons. In Xenopus oocytes, MEC-4 can assemble into homomeric channels and coassemble with MEC-10 into heteromeric channels (Goodman, M.B., G.G. Ernstrom, D.S. Chelur, R. O'Hagan, C.A. Yao, and M. Chalfie. 2002. Nature. 415:1039–1042). To gain insight into the structure–function principles that govern gating and drug block, we analyzed the effect of gain-of-function mutations using a combination of two-electrode voltage clamp, single-channel recording, and outside-out macropatches. We found that mutation of A713, the d or degeneration position, to residues larger than cysteine increased macroscopic current, open probability, and open times in homomeric channels, suggesting that bulky residues at this position stabilize open states. Wild-type MEC-10 partially suppressed the effect of such mutations on macroscopic current, suggesting that subunit–subunit interactions regulate open probability. Additional support for this idea is derived from an analysis of macroscopic currents carried by single-mutant and double-mutant heteromeric channels. We also examined blockade by the diuretic amiloride and two related compounds. We found that mutation of A713 to threonine, glycine, or aspartate decreased the affinity of homomeric channels for amiloride. Unlike the increase in open probability, this effect was not related to size of the amino acid side chain, indicating that mutation at this site alters antagonist binding by an independent mechanism. Finally, we present evidence that amiloride block is diffusion limited in DEG/ENaC channels, suggesting that variations in amiloride affinity result from variations in binding energy as opposed to accessibility. We conclude that the d position is part of a key region in the channel functionally and structurally, possibly representing the beginning of a pore-forming domain

Spectroscopy of 13B via the 13C(t,3He) reaction at 115 AMeV

Gamow-Teller and dipole transitions to final states in 13B were studied via the 13C(t,3He) reaction at Et = 115 AMeV. Besides the strong Gamow-Teller transition to the 13B ground state, a weaker Gamow-Teller transition to a state at 3.6 MeV was found. This state was assigned a spin-parity of 3/2- by comparison with shell-model calculations using the WBP and WBT interactions which were modified to allow for mixing between nhw and (n+2)hw configurations. This assignment agrees with a recent result from a lifetime measurement of excited states in 13B. The shell-model calculations also explained the relatively large spectroscopic strength measured for a low-lying 1/2+ state at 4.83 MeV in 13B. The cross sections for dipole transitions up to Ex(13B)= 20 MeV excited via the 13C(t,3He) reaction were also compared with the shell-model calculations. The theoretical cross sections exceeded the data by a factor of about 1.8, which might indicate that the dipole excitations are "quenched". Uncertainties in the reaction calculations complicate that interpretation.Comment: 11 pages, 6 figure

The Quantum-Classical Crossover in the Adiabatic Response of Chaotic Systems

The autocorrelation function of the force acting on a slow classical system, resulting from interaction with a fast quantum system is calculated following Berry-Robbins and Jarzynski within the leading order correction to the adiabatic approximation. The time integral of the autocorrelation function is proportional to the rate of dissipation. The fast quantum system is assumed to be chaotic in the classical limit for each configuration of the slow system. An analytic formula is obtained for the finite time integral of the correlation function, in the framework of random matrix theory (RMT), for a specific dependence on the adiabatically varying parameter. Extension to a wider class of RMT models is discussed. For the Gaussian unitary and symplectic ensembles for long times the time integral of the correlation function vanishes or falls off as a Gaussian with a characteristic time that is proportional to the Heisenberg time, depending on the details of the model. The fall off is inversely proportional to time for the Gaussian orthogonal ensemble. The correlation function is found to be dominated by the nearest neighbor level spacings. It was calculated for a variety of nearest neighbor level spacing distributions, including ones that do not originate from RMT ensembles. The various approximate formulas obtained are tested numerically in RMT. The results shed light on the quantum to classical crossover for chaotic systems. The implications on the possibility to experimentally observe deterministic friction are discussed.Comment: 26 pages, including 6 figure

Spectroscopy of 24Al and extraction of Gamow-Teller strengths with the 24Mg(3He,t) reaction at 420 MeV

The 24Mg(3He,t)24Al reaction has been studied at E(3He)=420 MeV. An energy resolution of 35 keV was achieved. Gamow-Teller strengths to discrete levels in 24Al are extracted by using a recently developed empirical relationship for the proportionality between Gamow-Teller strengths and differential cross sections at zero momentum transfer. Except for small discrepancies for a few weak excitations, good agreement with previous 24Mg(p,n) data and nuclear-structure calculations using the USDA/B interactions in the sd shell-model space is found. The excitation energy of several levels in 24Al of significance for determination of the 23Mg(p,gamma)24Al thermonuclear reaction rate were measured. Results are consistent with two of the three previous (3He,t) measurements, performed at much lower beam energies. However, a new state at Ex(24Al)=2.605(10) MeV was found and is the third state above the proton separation energy.Comment: 6 pages, 4 figure