Effect of tri-hydroxymethyl-aminomethane (Tris) on insulin secretion in vitro

The effect of tri-hydroxymethyl-aminomethane (TRIS) on insulin secretion was studied in vitro by incubation of pieces of pancreatic rat tissue. In control experiments, the rate of insulin secretion progressively increased as the glucose concentration of the incubation medium was raised from 100 to 300 mg. 100 ml. A further increase in insulin output was observed at each glucose concentration by raising the pH from 7.4 to 7.8 by adding NaOH. Added hypertonically at a 25 mM/L concentration, TRIS, did not induce an extra insulin release. The only significant effect corresponded to an inhibition of the insulin release induced by a high glucose concentration. This inhibitory effect of TRIS appeared to be increased in alkaline media and apparently was not due to hypertonicity. © 1970.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

PSEUDO-DIVERTICULOSE INTRAMURALE DE L'OESOPHAGE

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UNE TUMEUR OESOPHAGIENNE BENIGNE ET ASYMPTOMATIQUE CONSTITUE-T-ELLE UNE INDICATION OPERATOIRE?

Concerning a case of benign asymptomatic oesophageal tumour (leiomyoma) discovered by routine investigations, the authors consider the advisability of a resection. A survey of the literature as well as their personal cases together with the pathological data leads to advise systematic resection.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

EMPLOI DU THIAMPHENICOL DANS LES SUPPURATIONS PERITONEALES D'ORIGINE DIGESTIVE

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AMIODARONE ET FONCTION THYROIDIENNE

Amiodarone is a drug which is frequently used in cardiology, and which can lead to the appearance of hyper or hypo thyroidism in certain cases. A study of the various parameters of thyroid function has shown that these are abnormal in every case treated by this drug, without the biochemical abnormalities necessarily being reflected clinically. The authors outline a method which will allow a distinction to be drawn between patients with a true thyroid malfunction and those whose biochemical results do not appear at first sight to be of any consequence. Regular assays of the total triiodothyronine (T3RIA) level are suggested as a means of early detection of thyroid malfunction in patients undergoing treatment with amiodarone.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Cas rare de granulomatose hépatique

A case of tertiary hepatic syphilis is reported, allowing the authors to remind the rarity of this disease, though very anciently known, its poorly specific symptomatology, the necessity of a laparoscopic bioptic diagnosis, the debated response on the classical medical treatment and the probable absence of complications, other than portal hypertension. © 1983 Springer-Verlag.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Demeclocycline treatment of water retention in cirrhosis

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The application of linear discriminant analysis in the diagnosis of thyroid diseases

The effectiveness of five in-vitro laboratory tests for differentiation between three thyroid functional states (EU, HYPO and HYPER thyroidism) has been determined by using statistical linear discriminant analysis. The optimal linear combination of laboratory tests obtained by means of linear discriminant analysis results in a better use of the information present in each test, so that the possible redundancy of tests can be assessed. In this context, some feature selection criteria were evaluated. It is shown that in this application only two laboratory tests are necessary to obtain a sufficiently high diagnostic effectiveness when linear discriminant analysis is applied. © 1978.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence

The intrathyroidal stable iodine (ITI) was determined in 776 patients chosen at random. Ninety % of these patients presented with nontoxic goiter. Curve-filtering analysis techniques showed a seasonal variation in ITI: an acrophase was found in April/May, a nadir in Semptember/October. The possible relationship of this seasonal variation with the intake of iodine or alimentary antithyroid substances are discussed, as well as a possible relationship with variation in chronic TSH stimulation related to ambient temperature. © 1982, Italian Society of Endocrinology (SIE). All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

'Low T3 syndrome' in patients chronically treated with an iodine-containing drug, amiodarone

Cardiac patients treated with the iodine-containing drug 'amiodarone' undergo a significant iodine overload which can last for months after the drug has been withdrawn. Some patients develop hyperthyroidism and others hypothyroidism. In the hyper- or hypothyroid patients, the indices of thyroid function are modified as usually observed in these situations. In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine overload, a 'low-T3 syndrome' is observed, this state being characterized by a high total T4, a low free T4, a normal T3 resin uptake, a low total T3, a normal free T3, a high r-T3 and a relative TSH-unresponsiveness to TRH.SCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe