Atmospheric effects on the risetime and waveshape of sonic booms

Accurate prediction of human response to sonic booms from proposed HSCT aircraft depends on a knowledge of the waveshape and risetime of the boom at the ground. In previous work, we have developed a numerical technique to predict the combined effects of molecular absorption and finite wave distortion on the sonic boom as it propagates from the aircraft to the top of the turbulent boundary layer. We have more recently developed a scattering center based model to calculate the effects of turbulence on the sonic boom waveform as it propagates through this boundary layer. Calculations have been performed using single scales of turbulence and compared to measurements at Edwards AFB in the late 1960's. A model of the atmosphere involving two scales each for convective and mechanical turbulence has been developed and fit to meteorological data collected during JAPE 2. Scattering calculations employing this model underpredict the number of unperturbed waveforms. In order to develop a more realistic model of the atmosphere, the JAPE 2 meteorological data has been fit to a von Karman spectrum. Results of scattering using this multi-scale model will be presented. The combination of finite wave effects with turbulent scattering predictions includes the principal effects of the atmosphere on the sonic boom from the HSCT

Ground vibrations produced by surface and near-surface explosions

Measurements of seismic signatures produced by airborne, near-surface detonations of explosive charges over a variety of ground types show two distinct ground vibration arrivals. In all cases, the earlier arrival (precursor), has a time of arrival consistent with a predominantly underground path and coupling of blast sound to the ground close to the source and is always much smaller than the later vibration, the time of arrival of which is consistent with coupling from the air blast arrival at the receiver. The ratio of the seismic particle velocity to the acoustic pressure at the surface for the air-coupled seismic wave is constant with respect to distance and maximum pressure at a given location, but varies from site to site, with values usually between 1 and 13 μm s-1 Pa-1. For the precursor seismic wave, a coupling coefficient of 0.16 μm s-1 Pa-1 was measured. A numerical code enabling calculations of the fields due to an impulsive source above a layered poroelastic ground is described. Predictions of the air pressure spectrum above ground and the vertical and radial components of solid particle velocity near the ground surface are found to compare tolerably well with the measured spectra and waveforms of acoustic and seismic pulses at about 100 m range in seismically- hard and -soft soils and with a snow cover present. The predicted seismic responses in ‘soft’ soil confirm that the existence of a near-surface S-wave speed less than that in air is responsible for the observed ‘ringing’, i.e. a long low-frequency wavetrain associated with coupling to the dispersive Rayleigh wave. The predicted seismic pulses in the presence of the shallow snow cover explain the observed phenomenon whereby a high frequency ground vibration is modulated by a lower frequency layer resonance. An empirical equation relating ground vibration from explosions to distance predicts that the commonly- used vibrational damage peak velocity criterion of 12 or 25 mm s-1 will be exceeded when the peak positive pressure exceeds 480 Pa (147.6 dB) or 1 kPa (154.0 dB), respectively. Either of these levels is much higher than the current U.S. Army overpressure damage criterion of 159 Pa (138 dB). Thus in most situations damage from blast overpressure will occur long before damaging levels of ground vibration are reached, so it is likely that civilian perceptions of vibration are produced by coupling from the airblast

Dynamique d'un tourbillon fortement incliné dans un fluide stratifié

Nous nous intéressons expérimentalement à la dynamique d’un vortex incliné dans un fluide stratifié. Nous avons généré un tourbillon de pale dans une cuve stratifiée. Ce vortex possède un rayon critique pour lequel de fortes vitesses axiales sont générées, si la vitesse angulaire du vortex est suffisamment importante. La structure de cette couche critique est prédite théoriquement. Ces vitesses axiales déstabilisent le vortex très rapidement et créent un très fort mélange

Développement d’une méthode de dosage automatisé du méthotrexate dans le plasma humain par couplage direct à la chromatographie liquide de l’extraction sur phase solide à empreintes moléculaires

Peer reviewe

Reconstruction of source location in a network of gravitational wave interferometric detectors

This paper deals with the reconstruction of the direction of a gravitational wave source using the detection made by a network of interferometric detectors, mainly the LIGO and Virgo detectors. We suppose that an event has been seen in coincidence using a filter applied on the three detector data streams. Using the arrival time (and its associated error) of the gravitational signal in each detector, the direction of the source in the sky is computed using a chi^2 minimization technique. For reasonably large signals (SNR>4.5 in all detectors), the mean angular error between the real location and the reconstructed one is about 1 degree. We also investigate the effect of the network geometry assuming the same angular response for all interferometric detectors. It appears that the reconstruction quality is not uniform over the sky and is degraded when the source approaches the plane defined by the three detectors. Adding at least one other detector to the LIGO-Virgo network reduces the blind regions and in the case of 6 detectors, a precision less than 1 degree on the source direction can be reached for 99% of the sky.Comment: Accepted in Phys. Rev.

Muscle RANK is a key regulator of calcium storage, SERCA activity, and function of fast-twitch skeletal muscles

Receptor-activator of nuclear factor kB (RANK), its ligand RANKL and the soluble decoy receptor osteoprotegerin (OPG)are the key regulators of osteoclast differentiation and bone remodeling. Here we show that RANK is also expressed in fully differentiated myotubes and skeletal muscle. Muscle RANK deletion (RANKmko) has inotropic effects in denervated, but not in sham, extensor digitorum longus (EDL) muscle preventing the loss of maximum specific force while promoting muscle atrophy, fatigability and increased proportion of fast-twitch fibers. In denervated EDL muscles, RANK deletion markedly increased stromal interaction molecule 1 (Stim1) content, a calcium sensor, and altered activity of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) modulating Ca2+ storage. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus (Sol) muscles. These data identify a novel role for RANK as a key regulator of calcium storage and SERCA activity, ultimately affecting denervated skeletal muscle function

Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015

The 2015 update of the Canadian Stroke Best Practice Recommendations Hyperacute Stroke Care guideline highlights key elements involved in the initial assessment, stabilization, and treatment of patients with transient ischemic attack (TIA), ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and acute venous sinus thrombosis. The most notable change in this 5th edition is the addition of new recommendations for the use of endovascular therapy for patients with acute ischemic stroke and proximal intracranial arterial occlusion. This includes an overview of the infrastructure and resources required for stroke centers that will provide endovascular therapy as well as regional structures needed to ensure that all patients with acute ischemic stroke that are eligible for endovascular therapy will be able to access this newly approved therapy; recommendations for hyperacute brain and enhanced vascular imaging using computed tomography angiography and computed tomography perfusion; patient selection criteria based on the five trials of endovascular therapy published in early 2015, and performance metric targets for important time-points involved in endovascular therapy, including computed tomography-to-groin puncture and computed tomography-to-reperfusion times. Other updates in this guideline include recommendations for improved time efficiencies for all aspects of hyperacute stroke care with a movement toward a new median target door-toneedle time of 30 min, with the 90th percentile being 60 min. A stronger emphasis is placed on increasing public awareness of stroke with the recent launch of the Heart and Stroke Foundation of Canada FAST signs of stroke campaign; reinforcing the public need to seek immediate medical attention by calling 911; further engagement of paramedics in the prehospital phase with prehospital notification to the receiving emergency department, as well as the stroke team, including neuroradiology; updates to the triage and same-day assessment Conflict of interest: Leanne K. Casaubon: Medtronic (as an independent study patient assessor for a cardiac TAVI study); NoNO Inc. as site PI for the Frontier study of NA-1 neuroprotective in stroke; Covidien as an advisory board member. Jean-Martin Boulanger: conference speaker for BI Novartis, Sanofi Aventis, Merck, Merz, Allergan, Pfizer, Bayer, Boehringer Ingelheim. Gord Gubitz: speaker for Bayer, Boehringer Ingleheim, and BMS Pfizer. Dr. Michael D. Hill: Heart and Stroke Foundation of Alberta Board Chair, salary award holder; Vernalis Group Ltd and Merck Ltd Consultant; Hoffmann-LaRoche Canada, provided drug for clinical trial, consultancy and CME lecturer; Coviden, research grant holder; Servier Canada, CME lecturer (funds donated to charity); BMS Canada, consultancy (funds donated to charity); Alberta Innovates Health Solutions, program grant award; principal investigator, ESCAPE trial. Brian Moses: speaker for AstraZeneca, Bayer, Boehringer Ingelheim, Sanofi Aventis, and Servier; speaker and advisory board member for BMS, Eli Lilly, Merck, NovoNordisk, Pfizer; advisory board member for Medtronic. Funding: The development of the Canadian Stroke Best Practice Recommendations is funded in their entirety by the Heart and Stroke Foundation, Canada. No funds for the development of these guidelines come from commercial interests, including pharmaceutical and medical device companies. All members of the recommendation writing groups and external reviewers are volunteers and do not receive any remuneration for participation in guideline development, updates, and reviews. All participants complete a conflict of interest declaration prior to participation. of patients with transient ischemic attack; updates to blood pressure recommendations for the hyperacute phase of care for ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. The goal of these recommendations and supporting materials is to improve efficiencies and minimize the absolute time lapse between stroke symptom onset and reperfusion therapy, which in turn leads to better outcomes and potentially shorter recovery times