5 research outputs found
Effect of microneedling by dermaroller on acne scars: an observational study at tertiary care hospital
Background: Post acne facial scar is very distressing phenomenon. There are many treatment options like laser resurfacing, dermabrasion, microdermabrasion and non-ablative laser resurfacing but it may cause adverse effects and interference with the daily activities of the patient. Microneedling or dermaroller therapy is newer modality in management of acne scars with satisfactory improvement and no significant side effect. Objective of our study was to evaluate efficacy and safety of microneedling in the treatment of atrophic facial acne scars.
Methods: Twenty-eight patients of Fitzpatrick skin type IV to V having atrophic facial acne scars and fulfilling inclusion criteria were treated with multiple sittings of microneedling (dermaroller) treatment at monthly interval. Goodman and Baron’s qualitative and quantitative acne scar grading system was used for assessment. Patients were evaluated clinically and by serial photography. Presence of any active infection, active acne, wounds, blisters, keloids, taking some medications like Accutane, antihypertensives, anticoagulants, systemic retinoids, topical retinoids, those undergoing cosmetic procedures, treatment with injecting fillers or ablative or non-ablative laser resurfacing, diabetes, collagen diseases and those who do not agree to participate in study were excluded.
Results: Any change in the grading of scars after the end of treatment and follow-up period was noted. Efficacy and improvement of dermaroller treatment was assessed by Goodman and Baron’s global acne scarring system. Out of 18 patients (of total 28) with Goodman and Baron’s qualitative grade-4, 16 (88.90%) patients reduced to grade-1. 21 out of 28 patients achieved ‘excellent’ response. Adverse effects were limited to transient erythema and post inflammatory hyperpigmentation.
Conclusions: Microneedling therapy seems to be simple, safe and efficacious for the management of atrophic facial acne scars
THE IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME
A paradoxical clinical worsening of a known condition or the appearance of a new condition after initiating antiretroviral therapy in HIV-infected patients is defined as immune reconstitution inflammatory syndrome (IRIS). Because of wide variation in clinical presentation and the still increasing spectrum of symptoms and etiologies reported, diagnosis remains problematic. Furthermore, no test is currently available to establish an IRIS diagnosis. Until a greater understanding of the syndrome is achieved in different regions of the world, clinicians need to remain vigilant when initiating ART and individualize therapy according to known treatment options for the specific infectious agent
Kaposi's sarcoma: A presenting sign of HIV
Kaposi′s sarcoma (KS) is a multifocal cutaneous and extra
cutaneous vascular proliferative disorder. In India, there are only a
few cases of HIV-associated KS in published literature. A 26-year-old
married man presented with asymptomatic elevated skin lesions over the
face, trunk, both upper limbs and lower limbs with a duration of
one-and-a-half months. Cutaneous examination revealed multiple
violaceous papules and nodules, on the face (right upper and lower
eyelids, upper lip), trunk and proximal part of both limbs. Oral cavity
showed erythematous plaques, two in number, on the hard palate. Skin
biopsy showed proliferation of thin walled capillaries with formation
of slit like spaces, spindle cell proliferation, abundant extravasation
of RBCs and moderately dense inflammatory infiltrate in the dermis.
Thus a clinical diagnosis of cutaneous KS was confirmed. On testing
with ELISA for HIV, the patient was for the first time diagnosed as HIV
reactive. Thus KS was the presenting manifestation of HIV disease