Additional file 1: of Successful treatment of methotrexate intolerance in juvenile idiopathic arthritis using eye movement desensitization and reprocessing – treatment protocol and preliminary results

Table S1. EMDR standard protocol for MTX intolerance. (DOCX 37 kb

Additional file 1: of Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case–control study

Intake and duration of rheumatic drugs. (DOCX 28 kb

Health-related quality of life in JIA patients and the general German population.

<p>Age and gender standardized prevalence of problems in the five EQ5D dimensions with 95% confidence intervals.</p

Inclusion of study participants.

<p>Inclusion of study participants.</p

Overall comparison of problems in EQ5D domains between JIA patients and the German general population^a.

<p>Overall comparison of problems in EQ5D domains between JIA patients and the German general population<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153267#t003fn002" target="_blank">^a</a>.</p

Age and gender stratified comparison of the EQ5D domains between JIA patients and the German general population^a.

<p>Age and gender stratified comparison of the EQ5D domains between JIA patients and the German general population<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153267#t002fn002" target="_blank">^a</a>.</p

Associations between general and disease specific factors and HRQOL in JIA patients. Results of bivariate analyses and logistic regression models with EQ5D_Index as Outcome.

<p>Associations between general and disease specific factors and HRQOL in JIA patients. Results of bivariate analyses and logistic regression models with EQ5D_Index as Outcome.</p

Incidence of malignancies in patients with juvenile idiopathic arthritis: A retrospective single-center cohort study in Germany

<p><i>Objectives</i>: In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population.</p> <p><i>Methods</i>: A retrospective single-center hospital-based cohort study was performed using data on the JIA patients treated between 1952 and 2010 at the German Center for Pediatric and Adolescent Rheumatology (GCPAR) (Garmisch-Partenkirchen, Germany). Self-administered standardized questionnaires were sent out in 2012. Standardized incidence ratios (SIRs) and their corresponding 95% confidence intervals (95%CIs) were calculated.</p> <p><i>Results</i>: The study cohort consisted of 3691 JIA patients, and the response rate was 66%. Patients age ranged from 3 to 73 years of which 64% were female. Total follow-up time was 60,075 person-years; a history of malignancy was reported by 47 patients. Most common types of cancer were melanoma (<i>n</i> = 11), cervical cancer (<i>n</i> = 8) and breast cancer (<i>n</i> = 7). The overall SIR for women was 1.19 (95%CI: 0.77; 1.60) and for men was 0.67 (95%CI: 0.27; 1.07). The SIR for melanoma was 3.21 (95%CI: 1.60; 5.73) in women, whereas in men no melanoma cases were observed.</p> <p><i>Conclusion</i>: Although no overall increased cancer risk was found, results suggest that the risk of melanoma might be increased in female JIA patients.</p

Additional file 2: of Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

Figure S1. Expression of ANXA3 using RT-PCR: delta Ct values (relative expression values related to RPL) in controls, active systemic or polyarticular disease and inactive disease (***p < 0.001, ****p < 0.0001). Figure S2. Expression of IRAK3 using RT-PCR: delta Ct values (relative expression values related to RPL) in controls, active systemic or polyarticular disease and inactive disease (**p < 0.01). (DOCX 619 kb