CAPSTONE: A Summary of Flight Operations to Date in the Cislunar Environment

The cislunar environment is about to get much busier and with this increase in traffic comes an increase in the demand for limited resources such as Earth based tracking of and communications with assets operating in and around the Moon. With the number of NASA, commercial, and international missions to the Moon growing rapidly, the need to make these future endeavors as efficient as possible is a challenge that is being solved now. Advanced Space is aiming to mitigate these resource limitations by enabling spacecraft in the cislunar environment to navigate autonomously and reduce the need for oversubscribed ground assets for navigation and maneuver planning. Launched in June 2022, the Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment (CAPSTONE) mission utilizes a 12U CubeSat to demonstrate both the core software for the Cislunar Autonomous Positioning System (CAPS) as well as a validation of the mission design and operations of the Near Rectilinear Halo Orbit (NRHO) that NASA has baselined for the Artemis Lunar Gateway architecture. The CAPS software enables cislunar missions to manage their navigation functions themselves and reduces the reliance on Earth based tracking requirements without putting these missions at increased risk. Upon arrival in the NRHO, the CAPSTONE spacecraft will soon initiate its navigation demonstration mission in collaboration with the Lunar Reconnaissance Orbiter (LRO) operations team at NASA’s Goddard Space Flight Center to demonstrate autonomous inter-spacecraft ranging and autonomous navigation between the CAPSTONE spacecraft and LRO. Critical success criteria for CAPSTONE in this demonstration are 1) semi-autonomous operations and orbital maintenance of a spacecraft in an NRHO, 2) collection of inter-spacecraft ranging data, and 3) execution of the CAPS navigation software system in autonomous mode on-board the CAPSTONE spacecraft. Additionally, CAPSTONE continues to demonstrate an innovative one-way ranging navigation approach utilizing a Chip Scale Atomic Clock (CSAC), unique firmware installed on the Iris radio, and onboard autonomous navigation algorithms developed JPL an implemented by Advanced Space. Advanced Space, along with our partners at NASA’s Space Technology Mission Directorate, (STMD), Advanced Exploration Systems (AES), Launch Services Program (LSP), NASA Ames’ Small Spacecraft Office, the Jet Propulsion Lab (JPL), Terran Orbital and Rocket Lab, envision the CAPSTONE mission as a key enabler of both NASA’s upcoming Gateway operations involving multiple spacecraft and eventually the ever-expanding commercial cislunar economy. Over the next 21 months, CAPSTONE will demonstrate an efficient low energy orbital transfer to the lunar vicinity, an insertion into the NRHO, and a risk reducing validation of key exploration operations and technologies required for the ultimate success of NASA’s lunar exploration plans. This paper includes an overview of the mission, the current mission operational status, lessons learned from the launch, lunar transfer, and insertion into the NRHO, an overview of operations plan for the NRHO, and other lessons learned to date in order to inform future missions in support of national exploration and scientific objectives

CAPSTONE: A Summary of a Highly Successful Mission in the Cislunar Environment

NASA, Advanced Space, Terran Orbital, Rocket Lab, Stellar Exploration, JPL, the Space Dynamics Lab, and Tethers Unlimited have partnered to successfully develop, launch, and operate the Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment (CAPSTONE) mission, which is serving as a pathfinder for Near Rectilinear Halo Orbit (NHRO) operations around the Moon. This low-cost, high-value mission has demonstrated an efficient, low-energy orbital transfer to the Moon and a successful insertion into the Near Rectilinear Halo Orbit (NRHO), the intended orbit for NASA\u27s Gateway lunar orbital platform. The mission is now demonstrating operations within the NRHO that ultimately will serve to reduce risk and validate key exploration operations and technologies required for the future success of NASA\u27s lunar exploration plans, including the planned human return to the lunar surface. Over the next 9+ months, CAPSTONE will continue to validate these key operations and navigation technologies required for the success of NASA\u27s lunar exploration plans. This paper will include an overview of the current mission status, lessons learned from the launch, transfer, and insertion into the NRHO, a summary of the challenges encountered thus far, and an overview of the successful mission operations technology demonstrations thus far

Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations

<p>Abstract</p> <p>Background</p> <p>Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs (miRNAs) have become a major therapeutic focus as their pervasive expression and powerful regulatory roles in disease pathogenesis become increasingly apparent. Here we examine the role of miRNAs in FTLD patients with TAR DNA-binding protein 43 pathology (FTLD-TDP) caused by genetic mutations in the progranulin (<it>PGRN</it>) gene.</p> <p>Results</p> <p>Using miRNA array profiling, we identified the 20 miRNAs that showed greatest evidence (unadjusted P < 0.05) of dysregulation in frontal cortex of eight FTLD-TDP patients carrying <it>PGRN </it>mutations when compared to 32 FTLD-TDP patients with no apparent genetic abnormalities. Quantitative real-time PCR (qRT-PCR) analyses provided technical validation of the differential expression for 9 of the 20 miRNAs in frontal cortex. Additional qRT-PCR analyses showed that 5 out of 9 miRNAs (miR-922, miR-516a-3p, miR-571, miR-548b-5p, and miR-548c-5p) were also significantly dysregulated (unadjusted P < 0.05) in cerebellar tissue samples of <it>PGRN </it>mutation carriers, consistent with a systemic reduction in PGRN levels. We developed a list of gene targets for the 5 candidate miRNAs and found 18 genes dysregulated in a reported FTLD mRNA study to exhibit anti-correlated miRNA-mRNA patterns in affected cortex and cerebellar tissue. Among the targets is brain-specific angiogenesis inhibitor 3, which was recently identified as an important player in synapse biology.</p> <p>Conclusions</p> <p>Our study suggests that miRNAs may contribute to the pathogenesis of FTLD-TDP caused by <it>PGRN </it>mutations and provides new insight into potential future therapeutic options.</p

Analyse Transactionnelle Suisse romande – Recueil d'articles 2020

Articles diffusés par l'Association Suisse d’Analyse Transactionnelle – Suisse romande durant l'année 2020. Articles - Qu’est ce que l’AT apporte au monde ? - Enseignement spécialisé et AT – Entrevue - Conseil pédagogique et AT – Entrevue - L’accouchement-marathon - Les enjeux relationnels de la coopération - Les étapes de la coopération - La fosse de rösti – une mine d’or pour des expériences sur la diversité -La complexité par la diversité – Quelle signification pour la gestion des organisations ? - L’économie de l’autonomie – Les martiens ont-ils disparu ? - La coopération dans les institutions et hôpitaux – Entrevue Résumés - Le sens des valeurs que l’on porte - Interventions dans l’accompagnement professionnel de couples - Brunch entre amis - Lors des moments difficiles, l’AT nous porte - Counselling de couple avec AT et sexualité : un couple inégal ? - On devait toujours parler de tout... discussion père fille Divers - Éditorial - Prendre soin de nous durant la pandémie - Célébrons Fanita English, joyeux 104e anniversaire - Pleine conscience – regards croisés : retour sur la journée de l’ASAT-SR - Hommages à Jenni Hine - Entrevue avec Sally Cuénin - Anciens numéro