1-(3-Chloro­phen­yl)-4,4,6-trimethyl-3,4-dihydro­pyrimidine-2(1H)-thione

In the title compound, C13H15ClN2S, the dihydro­pyrimidine ring is essentially planar, with a maximum deviation from the least-squares plane of 0.122 (3) Å for the unsubstitued olefinic C atom. The dihedral angle between the dihydro­pyrimidine and benzene rings is 86.62 (13)°. The crystal structure is stabilized by inter­molecular N—H⋯S hydrogen bonds, which form centrosymmetric dimers arranged along the c axis

2,2,6,6-Tetra­methyl-4-oxopiperidin-1-ium 4-chloro-3-nitro­benzoate

The title salt, C9H18NO+·C7H3ClNO4 −, was obtained as an unexpected product of the reaction of 4-chloro-3-nitro­benzoyl isothio­cyanate with pyrrolidine. The six-membered ring of the 4-oxopiperidinium cation adopts a chair conformation. In the crystal structure, two cations and three anions are linked together by inter­molecular N—H⋯O and C—H⋯O hydrogen bonds and arranged diagonally along the ac face

1-(4-Methyl­benzo­yl)-3-{2-[3-(4-methyl­benzo­yl)thio­ureido]phen­yl}thio­urea

In the title compound, C24H22N4O2S2, the dihedral angles formed by the thio­ureido groups with the attached benzene ring are 43.81 (13) and 75.25 (13)°. The dihedral angle between the thio­ureido groups is 85.48 (10)°. The mol­ecule is stabilized by intra­molecular N—H⋯S, N—H⋯O and C—H⋯S hydrogen bonds. In the crystal, molecules are linked by intermolecular N—H⋯S hydrogen bonds together with C—H⋯π inter­actions

Ethylenediammonium-Dicarboxylate Salts and Co-Crystallization for Biological and Pharmaceutical Applications

Several ammonium type salts and co-crystals have been used in drug formulations to increase or decrease solubility, to improve stability, toxicity and also reducing the hygroscopicity of the products. Basically, a wide range of chemically diverse acidsand bases with different pKa, solubilities , molecular weight and other properties have been used for the purpose for a very long timein both drug and food formulations. In the present study, six ethylenediamminium salts containing thiocyanate and the anion derivedfrom diprotic acids namely oxalic (I), adipic (2), fumaric(3), succinic (4), azelaic (5) and sebacic (6) respectively, have been synthesized and characterized including their molecular structures. The difference in the pKa values of the acids unable the salt formation to be generalized. The molar conductivities of the salts are between 218 and 453 ohm-1cm2mol-1 with maximum value of 453 for salt (I). All the salts showed low activity against some selected bacteria and fungi and low toxicity against vero cell. The molecular structure of the salts will be presented and the biological activity will be compared with other ammonium salts

3-Nitro-N-[(pyrrolidin-1-yl)carbothioyl]benzamide

In the mol­ecule of the title compound, C12H13N3O3S, the pyrrolidine ring adopts a half-chair conformation and the dihedral angle formed by the nitro group with the benzene ring is 15.18 (18)°. In the crystal, mol­ecules are linked by N—H⋯S and C—H⋯O inter­molecular hydrogen bonds into chains parallel to the c axis

(±)-1,2-Bis(N′-benzoyl­thio­ureido)cyclo­hexa­ne

In the title compound, C22H24N4O2S2, the two thio­urea segments of the side-arm groups are inclined at a dihedral angle of 73.09 (9)°. The central cyclo­hexane bridge adopts a chair conformation. The mol­ecule is stabilized by N—H⋯O intra­molecular hydrogen bonds forming S(6) rings, and N—H⋯O and N—H⋯S inter­molecular hydrogen bonds forming infinite chains developing parallel to the b axis

3-Methyl-2-propionamido­butanoic acid

The reaction of propionyl isothio­cyanate with valine was found to give the title compound, C8H15NO3, instead of the expected thio­urea product. The whole mol­ecule is non-planar and the carbonyl group is cis to the methyl­butanoic acid group across the C—N bond. Inter­molecular O—H⋯O and N—H⋯O hydrogen bonds build up a two-dimensional network developing parallel to (100)

Complexation of 5,5,7,12,12,14-Hexamethyl-1,4,8,11-Tetraazayclotetradeca-7,14-Dienium Bromide With Copper Acetate In Methanol And Aqueous Solutions

5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclodeca-7,14-dienium bromide disolvate                       ((Me6N4H4)Br2.2H2O) is a 14-membered deprotonated tetraaza macrocyclic salt. Its neutral analogues and their complexes were prepared by templation method under refluxed condition since it was discovered by Curtis in 1961. However, the present diprotonated  tetraaza salts react with many metallic salts in both methanolic and aqueous solutions. The complexation involved deprotonation of the diagonally opposite protonated amines and the type of metal salt and solvents also play an important role in the final complex formation. The complexation of (Me6N4H4)Br2.2H2O with copper acetate in methanol and aqueous solutions gave the expected complex of  [Cu((Me6N4H2)Br]Br.2H2O. Pseudo-first order condition for the complexation reaction in water was established

N-(4-Bromo­butano­yl)-N′-phen­ylthio­urea

The asymmetric unit of the title compound, C11H13Br1N2O1S1, consists of two independent mol­ecules, which are linked by N—H⋯O hydrogen bonds, forming a dimer. Both mol­ecules maintain the trans--cis configuration with respect to the position of the butanoyl groups and benzene rings against the thiono group across the C—N bonds. The mol­ecule is stabilized by intra­molecular N—H⋯O hydrogen bonds. Inter­molecular N—H⋯S, C—H⋯S and C—H⋯π inter­actions also occur

Propyl 2-(3-benzoyl­thio­ureido)acetate

The title compound, C13H16N2O3S, is a thio­urea derivative with benzoyl and propoxycarbonyl­methyl groups attached to the two terminal N atoms. These groups adopt trans and cis configurations, respectively, with respect to the S atom across the thio­urea C—N bonds. The compound crystallizes in the P21/c space group with Z = 8, resulting in two unique molecules in the asymmetric unit linked by C—H⋯S and C—H⋯O hydrogen bonds, forming a one-dimensional zigzag chain along the c axis