A collaborative model to implement flexible, accessible and efficient oncogenetic services for hereditary breast and ovarian cancer : the C-MOnGene study

Medical genetic services are facing an unprecedented demand for counseling and testing for hereditary breast and ovarian cancer (HBOC) in a context of limited resources. To help resolve this issue, a collaborative oncogenetic model was recently developed and implemented at the CHU de Québec-Université Laval; Quebec; Canada. Here, we present the protocol of the C-MOnGene (Collaborative Model in OncoGenetics) study, funded to examine the context in which the model was implemented and document the lessons that can be learned to optimize the delivery of oncogenetic services. Within three years of implementation, the model allowed researchers to double the annual number of patients seen in genetic counseling. The average number of days between genetic counseling and disclosure of test results significantly decreased. Group counseling sessions improved participants' understanding of breast cancer risk and increased knowledge of breast cancer and genetics and a large majority of them reported to be overwhelmingly satisfied with the process. These quality and performance indicators suggest this oncogenetic model offers a flexible, patient-centered and efficient genetic counseling and testing for HBOC. By identifying the critical facilitating factors and barriers, our study will provide an evidence base for organizations interested in transitioning to an oncogenetic model integrated into oncology care; including teams that are not specialized but are trained in genetics

Chikungunya virus-induced autophagy delays caspase-dependent cell death

Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a major epidemic in India, Southeast Asia, and southern Europe, we reveal a novel mechanism by which autophagy limits cell death and mortality after infection. We use biochemical studies and single cell multispectral assays to demonstrate that direct infection triggers both apoptosis and autophagy. CHIKV-induced autophagy is mediated by the independent induction of endoplasmic reticulum and oxidative stress pathways. These cellular responses delay apoptotic cell death by inducing the IRE1α–XBP-1 pathway in conjunction with ROS-mediated mTOR inhibition. Silencing of autophagy genes resulted in enhanced intrinsic and extrinsic apoptosis, favoring viral propagation in cultured cells. Providing in vivo evidence for the relevance of our findings, Atg16L(HM) mice, which display reduced levels of autophagy, exhibited increased lethality and showed a higher sensitivity to CHIKV-induced apoptosis. Based on kinetic studies and the observation that features of apoptosis and autophagy were mutually exclusive, we conclude that autophagy inhibits caspase-dependent cell death but is ultimately overwhelmed by viral replication. Our study suggests that inducers of autophagy may limit the pathogenesis of acute Chikungunya disease

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction

Characterizing Prostate Cancer Risk Through Multi-Ancestry Genome-Wide Discovery of 187 Novel Risk Variants

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups

Éduquer aux plurilinguismes et à la diversité en contextes francophones : démarches et outils / Claire Vilpoux, Philippe Blanchet

International audienc

La rénovation de l'enseignement du français dans les universités en Ukraine (une analyse didactique contextualisée)

Depuis les années 1990, l Ukraine s est lancée dans un processus de réformes touchant tous les secteurs de lasociété. Dans les universités, de nouvelles approches pédagogiques pour l amélioration de l enseignement dufrançais ont été mises en place. Dans ce mouvement, un projet de rénovation a été développé par l Attaché deCoopération Pour le Français et une vingtaine de départements et filières de français. Quels ont été les impacts decette rénovation au sein des universités ukrainiennes? À partir d une enquête de terrain, mettant en lumière lespratiques d enseignement et les représentations sociolinguistiques des acteurs de l enseignement-apprentissagedu français, cette recherche tente de mieux comprendre les diverses dynamiques à l oeuvre. Elle se pencheessentiellement sur les transformations de l enseignement supérieur et la diffusion de la langue française. Aprèsune explicitation de la démarche épistémologique et méthodologique retenue, une problématisation du contexteukrainien est proposée autour de la question du plurilinguisme au sein de la société et au sein du système éducatif.L attention est portée ensuite sur le développement de l enseignement du français. Ce travail de contextualisationpermet, d une part, de dégager les éventuelles tensions qui entourent et constituent la rénovation del enseignement du français, et, d autre part, d envisager des pistes sociodidactiques répondant mieux aux besoinsdes universités ukrainiennesSince the 1990s, Ukraine was involved in a process of reform in all sectors of the society. Universities put intopractice new pedagogical approaches to improve French teaching. As a result, a renewal of French teaching wasdeveloped by the Attaché of Cooperation for the development of French language and twenty branch departments.Which were the impacts of this renewal of French teaching in the Ukrainian universities? In the scope of a fieldstudy, we observed and reviewed teaching practices and sociolinguistic representations of the actors in theteaching and learning French language. By this way, we strive to better understand the various dynamics whichcontribute to the development of teaching and learning French language in Ukrainian universities. This study willfocus mainly on the transformations of higher education and the diffusion of French language. First, we will explainthe epistemological and methodological framework. Then, we will question the Ukrainian context in order tounderstand specifities related to plurilinguism in society and in the educational system. On the one hand, we willidentify the possible tensions already existing or emerging from this renewal. On the other hand, we will considerhow teaching French could be contextualized in Ukrainian universities in order to answer the needs of UkrainianuniversitiesRENNES2-Doc.électronique (352389902) / SudocSudocFranceF

Evaluation of sorghum genotypes for agronomic and food quality characteristics for pitimi (rice-like product)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Bibliography: leaves 74-80.Not availabl