Causality detection and turbulence in fusion plasmas

This work explores the potential of an information-theoretical causality detection method for unraveling the relation between fluctuating variables in complex nonlinear systems. The method is tested on some simple though nonlinear models, and guidelines for the choice of analysis parameters are established. Then, measurements from magnetically confined fusion plasmas are analyzed. The selected data bear relevance to the all-important spontaneous confinement transitions often observed in fusion plasmas, fundamental for the design of an economically attractive fusion reactor. It is shown how the present method is capable of clarifying the interaction between fluctuating quantities such as the turbulence amplitude, turbulent flux, and Zonal Flow amplitude, and uncovers several interactions that were missed by traditional methods.Comment: 26 pages, 14 figure

Modulation of GLO1 expression affects malignant properties of cells

The energy metabolism of most tumor cells relies on aerobic glycolysis (Warburg effect) characterized by an increased glycolytic flux that is accompanied by the increased formation of the cytotoxic metabolite methylglyoxal (MGO). Consequently, the rate of detoxification of this reactive glycolytic byproduct needs to be increased in order to prevent deleterious effects to the cells. This is brought about by an increased expression of glyoxalase 1 (GLO1) that is the rate-limiting enzyme of the MGO-detoxifying glyoxalase system. Here, we overexpressed GLO1 in HEK 293 cells and silenced it in MCF-7 cells using shRNA. Tumor-related properties of wild type and transformed cells were compared and key glycolytic enzyme activities assessed. Furthermore, the cells were subjected to hypoxic conditions to analyze the impact on cell proliferation and enzyme activities. Our results demonstrate that knockdown of GLO1 in the cancer cells significantly reduced tumor-associated properties such as migration and proliferation, whereas no functional alterations where found by overexpression of GLO1 in HEK 293 cells. In contrast, hypoxia caused inhibition of cell growth of all cells except of those overexpressing GLO1. Altogether, we conclude that GLO1 on one hand is crucial to maintaining tumor characteristics of malignant cells, and, on the other hand, supports malignant transformation of cells in a hypoxic environment when overexpressed

Connecting the global H-mode power threshold to the local radial electric field at ASDEX Upgrade

The relation between the macroscopic input power required at ASDEX Upgrade to access the H-mode Pthr and the microscopic E x B shear has been investigated via fast charge-exchange recombination spectroscopy (CXRS) measurements at various toroidal magnetic fields, different electron densities, and in both hydrogen and deuterium plasmas. For the H-mode onset, a threshold in the v E x B minimum, an approximation of the E x B shear, has been found. This identifies v E x B and not Er as the important player for the L-H transition. A database of measurements including CXRS, Doppler reflectometry measurements and comparison to neoclassical approximations shows a threshold v E x B of (6.7 ± 1.0) km/s ranging over a factor of three in Pthr. Using these findings, a simple derivation of the Pthr scaling is proposed giving a physics interpretation of the Bt, density and surface dependence of Pthr.EUROfusion Consortium Grant Agreement No. 63305