Color television study Final report, Nov. 1965 - Mar. 1966

Color television camera for transmission from lunar and earth orbits and lunar surfac

Retrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors

OBJECTIVE—Of deceased pancreas donors, 3–4% may have autoantibodies (AAb) to pancreatic islet cell antigens; these autoantibodies are well-established markers of type 1 diabetes. We investigated whether donor AAb positivity could affect the outcome of pancreas transplantation

Fretting–corrosion at the modular tapers interface: Inspection of standard ASTM F1875-98

Interest in the degradation mechanisms at the modular tapers interfaces has been renewed due to increased reported cases of adverse reactions to metal debris and the appearance of wear and corrosion at the modular tapers interfaces at revision. Over the past two decades, a lot of research has been expended to understand the degradation mechanisms, with two primary implant loading procedures and orientations used consistently across the literature. ASTM F1875-98 is often used as a guide to understand and benchmark the tribocorrosion processes occurring within the modular tapers interface. This article presents a comparison of the two methods outlined in ASTM F1875-98 as well as a critique of the standard considering the current paradigm in pre-clinical assessment of modular tapers

Child support reform: some analysis of the 1999 white paper

This paper uses a sample of lone mothers (and former lone mothers who are now repartnered) drawn from the 1997 Family Resources Survey to analyse the potential effects of reforming the UK system of Child Support. The main deficiency of the data is that non-resident fathers cannot be matched to the mothers in the data and this is overcome by exploiting information from another dataset which gives the joint distribution of the characteristics of separated parents. The effects of reforming the Child Support system is simulated for the amount of maintenance liabilities, the amount paid and the net incomes of households containing mothers with care and households containing non-resident fathers. The likely effects of the reform are simulated at various levels of compliance. The analysis highlights the need for further research into the incentive effects of Child Support on individual behaviour

Status of TIGA activities at the British Isles continuous GNSS Facility and the University of Luxembourg

In 2013 the InternationalGNSS Service (IGS) Tide Gauge Benchmark Monitoring (TIGA) Working Group started their reprocessing campaign which proposes to reanalyse all relevant GPS observations from 1995 to the end of 2012 in order to provide high quality estimates of vertical land motion for monitoring of sea level changes. The TIGA Working Group will also produce a combined solution from the individual TIGA Analysis Centres (TAC) contributions. The consortium of British Isles continuous GNSS Facility (BIGF) and the University of Luxembourg TAC (BLT) will contribute weekly minimally constrained SINEX solutions from its reprocessing using the Bernese GNSS Software (BSW) version 5.2 and the University of Luxembourg will also act as a TIGA Combination Centre (TCC). The BLT will generate two solutions, one based on BSW5.2 using a network double difference (DD) strategy and a second one based on BSW5.2 using a Precise Point Positioning (PPP) strategy. In the DD strategy we have included all IGb08 core stations in order to achieve a consistent reference frame implementation. As an initial test for the TIGA combination, all TACs agreed to provide weekly SINEX solutions for a four-week period in December 2011. Taking these individual TAC solutions the TCC has computed a first combination using two independent combination software packages: CATREF and GLOBK. In this study we will present preliminary results rom the BLT reprocessing and from the combination tests

Generation of virtual geometric domains for woven textile composites

The definition of an appropriate geometric domain is a prerequisite for performing virtual thermo-mechanical analyses on materials. Most of the current methods for generating virtual geometric domains for textile composites rely on complex equations conjured from the machining/manufacturing of the textiles; consequently, an intuitive method for developing a variety of virtual geometric domains for woven textile composites is desirable. The literature describes several techniques for generating geometric models for textile composites using advanced energy minimisation principles and computational imaging tools, but these techniques require specialist equipment, for deducing necessary empirical data, and heuristics to obtain acceptable results. This communication proposes a method for generating virtual geometric models using simple geometric metrics from the topology of the desired woven textiles. We describe and implement a geometric modelling algorithm for generating woven textile composites and show that the proposed technique yields geometric models with comparable characteristics to actual textile fabrics. Due to its modular structure, the proposed algorithm can be readily implemented on any programming platform and adapted to generate bespoke woven textile fabrics. This has been demonstrated by generating CAD models of woven textiles which can be adopted in any pre-processing tool for subsequent analysis in a finite element scheme

Rationale and protocol for the After Diabetes Diagnosis REsearch Support System (ADDRESS): an incident and high risk type 1 diabetes UK cohort study

INTRODUCTION: Type 1 diabetes is heterogeneous in its presentation and progression. Variations in clinical presentation between children and adults, and with ethnic group warrant further study in the UK to improve understanding of this heterogeneity. Early interventions to limit beta cell damage in type 1 diabetes are undergoing evaluation, but recruitment is challenging. The protocol presented describes recruitment of people with clinician-assigned, new-onset type 1 diabetes to understand the variation in their manner of clinical presentation, to facilitate recruitment into intervention studies and to create an open-access resource of data and biological samples for future type 1 diabetes research. METHODS AND ANALYSIS: Using the National Institute for Health Research Clinical Research Network, patients >5 years of age diagnosed clinically with type 1 diabetes (and their siblings) are recruited within 6 months of diagnosis. Participants agree to have their clinical, laboratory and demographic data stored on a secure database, for their clinical progress to be monitored using information held by NHS Digital, and to be contacted about additional research, in particular immunotherapy and other interventions. An optional blood sample is taken for islet autoantibody measurement and storage of blood and DNA for future analyses. Data will be analysed statistically to describe the presentation of incident type 1 diabetes in a contemporary UK population. ETHICS AND DISSEMINATION: Ethical approval was obtained from the independent NHS Research Ethics Service. Results will be presented at national and international meetings and submitted for publication to peer-reviewed journals.This work was supported by Diabetes UK grant number 09/0003919 and the Juvenile Diabetes Research Foundation grant number 9-2010-407. Recruitment is supported by staff at the National Institute for Health Research Clinical Research Network

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives:A Feasibility Study

Background: Islet autoantibody testing provides the basis for assessment of risk of progression to type 1 diabetes. We set out to determine the feasibility and acceptability of dried capillary blood spot–based screening to identify islet autoantibody–positive relatives potentially eligible for inclusion in prevention trials. Materials and Methods: Dried blood spot (DBS) and venous samples were collected from 229 relatives participating in the TrialNet Pathway to Prevention Study. Both samples were tested for glutamic acid decarboxylase, islet antigen 2, and zinc transporter 8 autoantibodies, and venous samples were additionally tested for insulin autoantibodies and islet cell antibodies. We defined multiple autoantibody positive as two or more autoantibodies in venous serum and DBS screen positive if one or more autoantibodies were detected. Participant questionnaires compared the sample collection methods. Results: Of 44 relatives who were multiple autoantibody positive in venous samples, 42 (95.5%) were DBS screen positive, and DBS accurately detected 145 of 147 autoantibody-negative relatives (98.6%). Capillary blood sampling was perceived as more painful than venous blood draw, but 60% of participants would prefer initial screening using home fingerstick with clinic visits only required if autoantibodies were found. Conclusions: Capillary blood sampling could facilitate screening for type 1 diabetes prevention studies.</p