Comparison of Letrozole and Clomiphene citrate on ovulation in achievement of successful Pregnancy

Objective: to compare the efficacy of letrozole and clomiphene citrate in terms of pregnancy achievement and in anovulatory infertile women. Study Design: A randomized controlled trial. Place and Duration: study conducted at the department of obstetrics and gynaecology DG Khan Teaching Hospital. DG Khan from March 2017 to March 2018. Methodology: Two hundred and ten patients were included in this study. The patients were equally divided into two Groups as Group A and Group B by random number method. Study was started after permission from hospital ethical committee. Study variables were age and duration of infertility. SPSS version 24 was used to analyze data. T test and chi square test were applied and p≤0.05 was taken as significant.  Results: the mean age and duration of infertility of Group B was 25.66±3.39 years and 3.72±2.01 years, respectively. There were 73.3% patients between 18-30 years and 26.7% in 31-40 years of age. There were 79% patients had <5 years of duration of infertility and 21% had >5 years of duration of infertility. The difference was statistically significant (p=0.000) for age. The efficacy of Group A and B was observed as 16.2% and 45.7%, respectively. The difference was statistically significant, (p=0.000). Conclusion: use of Letrzole is safe and more effective for achieving pregnancy in anovulatory infertile women as compared to clomiphene citrate. Keywords: Letrozole, Clomiphene Citrate, Ovulation, pregnancy rate, Infertility

Relation of Striae Gravidarum with Cesarean Scar and Peritoneal Adhesions

Objective: to find out the relation between striae gravidarum and, cesarean scar and peritoneal adhesions. Study Design: Cross sectional Study. Place and Study Duration: Department of Gynecology and Obstetrics, DG Khan Teaching Hospital Multan, from January 2018 to June 2018. Material and methods: A total number of 150 patients presenting to the department of gynecology and obstetrics for cesarean section were included in the study. Severity of striae gravidarum was assessed using Davey scoring system. Modified Blauer classification was used to define the intraperitoneal adhesions in five categories. Three groups were designed group 1, 2 and 3. In group 1 those women were involved that had no striae gravidarum, in group 2 were those women who had mild to moderate number of striae gravidarum and in group 3 women with severe amount of striae gravidarum were included. Students T test and Mann-Whitney test was applied to compare the two groups. Frequency and percentages were calculated for categorical variables and mean and standard deviation was calculated for continuous variables. P value of less than or equal to 0.05 was considered as statistically significant. Results: Grade 2-4 intraperitoneal adhesions, keloids and pigmentations were more in Group 2 and Group 3 but no statistically significant difference was present (p-value 0.517, 0.427 and 0.372, respectively). The appearance of scar was also not different among the three groups (p=0.541). Scar length was more in Group-3 (p=0.289) but the width was more in Group-1 (p=0.248) with no statistically significant difference. Conclusion: The results of this study show that striae gravidarum was associated with scar characteristics but no correlation between striae gravidarum and intraperitoneal adhesions could be observed as such. Keywords: Striae Gravidarum, Cesarean Section, Abdominal Adhesion

Occupational Health Hazard among Health Care Workers in a Tertiary Care Hospital, Lahore

Background: Occupational health is a neglected public health issue among healthcare workers in developing countries and they may expose them to various forms of hazards. Objectives: The study aims at exploring the forms of occupational health hazards among nurses in a tertiary care hospital, Lahore Methods: Total 151 staff nurses were enrolled for cross-sectional descriptive study to explore the occupational health hazard.  This study was conducted at Lahore General Hospital, Lahore for the duration of 02, 2021, to January 01, 2022. Only charge nurses working in medical and surgical units on permanent basis having experience more than six months were included. Results: The findings of this study showed that the mean age of the nurse was 25.87 ± 3.138 years (age range 21-32 year), the female nurse was  127(84.1%)while 24(15.9%) were male nurse. The participants faced occupational health hazards 51.8%, biological hazards73.5%, and physical hazards 59.2% and mechanical and psychology Hazards among Nurse 48.8% and 52.0% respectively. Conclusion:Occupational risks (biological hazards) are very common among the nurses in Lahore General Hospital, Lahore. To protect patients and medical staff, hospitals should implement preventative, infection control, and patient safety initiatives. Keywords: Occupational hazards;  Health workers;  Lahore General Hospital DOI: 10.7176/JHMN/104-05 Publication date: November 30th 202

ETHNOBOTANICAL AND BIOLOGICAL ACTIVITIES OF Leptadenia pyrotechnica (Forssk.) Decne.: A REVIEW

Background: Leptadenia pyrotechnica is traditionally used for treating various diseases. This species holds variety of bioactive constituents that trigger healing properties. The present review was aimed to analyze nutritional, phytochemical and pharmacological activities of L. pyrotechnica. Materials and Methods: The present review regarding Leptadenia pyrotechnica (Forssk.) Decne. Is the compilation of data from the previous research works conducted by various scientists across the world. Various published papers, medicinal plant databases,etc were utilized to compile the information. Results: L. pyrotechnica is a wonderful desert plant belongs to the family Asclepiadaceae This plant possesses antifungal, antibacterial, anticancer, antioxidant, wound healing, anthelmintic, antiatheroscloretic, hypolipidemic, antdiabetic and hepatoprotective activities coupled with other multifarious uses. Almost all plant parts are used in the traditional medicinal system to treat various disorders. Conclusion: This review includes the substance of different ethnobotanical uses, phytochemistry and exclusive capability of this plant in the field of anti-microbial and human disease activities

Hierarchical plant extracts in silver nanoparticles preparation: Minuscular survey to achieve enhanced bioactivities

Extracts obtained from M. longifolia (Lamiaceae) and R. ellipticus (Rosaceae) were selected to utilize in the reduction and stabilization of silver nanoparticles (AgNPs) for achieving remarkable bioactivities. In brief, the cytotoxic potential of the as synthesize AgNPs was high at higher concentrations. In DPPH assay, maximum antioxidant potential was shown by AgNPs synthesized from M. longifolia. Meanwhile, Methanolic extracts exhibited more antioxidant potential than chloroform based extracts.Further, brine shrimp lethality assay was carried out to achieve 34.6 μg/mL & 25.65 μg/mL LD50 values against the NPs prepared from M. and R., respectively. In addition, antioxidant activities were carried by ABTS Radical cation assay where 38.6 μg/mL and 47 μg/mL IC50 values were obtained for the NPs obtained from M. longifolia and R. ellipticus, respectively. Reducing power assay (0.370–0.15 and 0.37–0.26 mean absorbance) and DPPH (% scavenging: 88.91–46.48 and 88.91–44.78) percentages were recorded for M. and R. synthesized AgNPs, respectively.In brief, M. longifolia functionalized particles performed better in comparison to R. ellipticus treated particles. In addition, the nano assembly dispersed in polar solvent demonstrated better results in comparison to non-polar solvents.In conclusion, the as synthesized AgNPs were better in bioactivities than crude extracts of the selected plants.In future, this work could be extended to isolating active components for the nanofabrication of biologically intelligent nanoparticles for pharmacological interest. In the proposed investigation, the purified bioactivities fractions would be highlighted for further consideration in various medical treatments

Blockchain Technology: A Research Review

We are going through an era of emerging new technologies where every day brings innovation in the business world. These technologies are influencing the world of business and also challenging its traditional way; one of them is Blockchain technology, which is known as fourth industrial revolution. After the advent of bitcoin blockchain technology gained popularity as crypto platform. Trustworthiness, transparencey, and controlled features of this technology attracted many or almost every organization. Because of its decentralized feature its being used in every sector not just in bitcoins. A huge research is being done on this technology, this paper is based on the liertaure review of blockchain technology, its history, applications in different sectors, how it performs, and at the end future research directions and gap is discussed

Emerging role of SMYD family of proteins in human tumorigenesis

Protein lysine methylation is a post-translational modification (PTM) that promotes protein complex formation to regulate DNA replication, gene expression, and repair mechanisms. The Su(Var)3–9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing proteins SMYD are lysine methyltransferases that catalyze the methylation of various histone and non-histone proteins. There are five members of this SMYD family, and all of these have conserved SET and MYND domains. The SET domain is divided into two segments by the MYND domain (the S-sequence and a core SET domain). SMYD Family performs a key role in numerous biological functions, including growth, development, apoptosis, and proliferation. SMYD family members are associated with skeletal and cardiac muscle physiology and pathology. Several studies have shown that aberrant lysine methylation plays a significant role in oncogenesis. Recently, the SMYD family has gained importance for its role in various mechanisms involved in cancer development and progressions, such as methylation and modification of tumor suppressor proteins (p53 and pRb), transcriptional factors (STAT3, NF-κB), nuclear proteins (PARP1), chaperons (Hsp90), protein kinases (MAPK, ERK), and cell cycle regulatory proteins (CDKN2). SMYD family proteins drive oncogenesis, lead the way to metastasis, and develop chemoresistance, allowing cancer cells to grow, invade the neighboring tissues, and resist therapeutics. In this review, we summarize SMYD family members’ role in different cancers by focusing on their histone and non-histone methylation targets and illustrating the mechanism of SMYD family-mediated oncogenesis

Enhanced Learning Enriched Features Mechanism Using Deep Convolutional Neural Network for Image Denoising and Super-Resolution

Image denoising and super-resolution play vital roles in imaging systems, greatly reducing the preprocessing cost of many AI techniques for object detection, segmentation, and tracking. Various advancements have been accomplished in this field, but progress is still needed. In this paper, we have proposed a novel technique named the Enhanced Learning Enriched Features (ELEF) mechanism using a deep convolutional neural network, which makes significant improvements to existing techniques. ELEF consists of two major processes: (1) Denoising, which removes the noise from images; and (2) Super-resolution, which improves the clarity and details of images. Features are learned through deep CNN and not through traditional algorithms so that we can better refine and enhance images. To effectively capture features, the network architecture adopted Dual Attention Units (DUs), which align with the Multi-Scale Residual Block (MSRB) for robust feature extraction, working sidewise with the feature-matching Selective Kernel Extraction (SKF). In addition, resolution mismatching cases are processed in detail to produce high-quality images. The effectiveness of the ELEF model is highlighted by the performance metrics, achieving a Peak Signal-to-Noise Ratio (PSNR) of 42.99 and a Structural Similarity Index (SSIM) of 0.9889, which indicates the ability to carry out the desired high-quality image restoration and enhancement