Techniques for QCD calculations by numerical integration

Calculations of observables in quantum chromodynamics are typically performed using a method that combines numerical integrations over the momenta of final state particles with analytical integrations over the momenta of virtual particles. I describe the most important steps of a method for performing all of the integrations numerically.Comment: 36 pages with 16 postscript figure

Chirality of tensor perturbations for complex values of the Immirzi parameter

In this paper we generalise previous work on tensor perturbations in a de Sitter background in terms of Ashtekar variables to cover all complex values of the Immirzi parameter gamma (previous work was restricted to imaginary gamma). Particular attention is paid to the case of real gamma. Following the same approach as in the imaginary case, we can obtain physical graviton states by invoking reality and torsion free conditions. The Hamiltonian in terms of graviton states has the same form whether gamma has a real part or not; however changes occur for the vacuum energy and fluctuations. Specifically, we observe a gamma dependent chiral asymmetry in the vacuum fluctuations only if gamma has an imaginary part. Ordering prescriptions also change this asymmetry. We thus present a measurable result for CMB polarisation experiments that could shed light on the workings of quantum gravity.Comment: 6 pages, 1 figur

Successive Combination Jet Algorithm For Hadron Collisions

Jet finding algorithms, as they are used in $e^+ e^-$ and hadron collisions, are reviewed and compared. It is suggested that a successive combination style algorithm, similar to that used in $e^+ e^-$ physics, might be useful also in hadron collisions, where cone style algorithms have been used previously.Comment: 18 pages plus four uuencoded postscript figures, REVTEX 3.0, CERN-TH.6860/9

Searching For Anomalous τνW\tau \nu W Couplings

The capability of current and future measurements at low and high energy $e^+e^-$ colliders to probe for the existence of anomalous, CP conserving, $\tau \nu W$ dipole moment-type couplings is examined. At present, constraints on the universality of the tau charged and neutral current interactions as well as the shape of the $\tau \to \ell$ energy spectrum provide the strongest bounds on such anomalous couplings. The presence of these dipole moments are shown to influence, e.g., the extraction of $\alpha_s(m_\tau^2)$ from $\tau$ decays and can lead to apparent violations of CVC expectations.Comment: 24 pages, 9 figure

Value of alpha_s from deep-inelastic-scattering data

We report the value of $\alpha_{\rm s}$ obtained from QCD analysis of existing data on deep-inelastic scattering of charged leptons off proton and deuterium and estimate its theoretical uncertainties with particular attention paid to impact of the high-twist contribution to the deep-inelastic-scattering structure functions. Taking into account the major uncertainties the value $\alpha^{\rm NNLO}_{\rm s}(M_{\rm Z})=0.1143 \pm 0.0014({\rm exp.})\pm 0.0013({\rm theor.})$ is obtained. An extrapolation of the LO--NLO--NNLO results to the higher orders makes it possible to estimate $\alpha^{\rm N^3LO}_{\rm s}(M_{\rm Z})\sim 0.113$.Comment: 9 pages, LATEX, 4 figures (EPS). Talk given at 16th International Baldin Seminar on High-Energy Physics Problems: Relativistic Nuclear Physics and Quantum Chromodynamics (ISHEPP 16), Dubna, Russia, 10-15 Jun 200; v2: typos corrected, layout improved, 2 references adde

Determination of the Strong Coupling \boldmath{\as} from hadronic Event Shapes and NNLO QCD predictions using JADE Data

Event Shape Data from $e^+e^-$ annihilation into hadrons collected by the JADE experiment at centre-of-mass energies between 14 GeV and 44 GeV are used to determine the strong coupling $\alpha_S$. QCD predictions complete to next-to-next-to-leading order (NNLO), alternatively combined with resummed next-to-leading-log-approximation (NNLO+NLLA) calculations, are used. The combined value from six different event shape observables at the six JADE centre-of-mass energies using the NNLO calculations is $\alpha_S(M_Z)$= 0.1210 +/- 0.0007(stat.) +/- 0.0021(expt.) +/- 0.0044(had.) +/- 0.0036(theo.) and with the NNLO+NLLA calculations the combined value is $\alpha_S$= 0.1172 +/- 0.0006(stat.) +/- 0.0020(expt.) +/- 0.0035(had.) +/- 0.0030(theo.) . The stability of the NNLO and NNLO+NLLA results with respect to missing higher order contributions, studied by variations of the renormalisation scale, is improved compared to previous results obtained with NLO+NLLA or with NLO predictions only. The observed energy dependence of $\alpha_S$ agrees with the QCD prediction of asymptotic freedom and excludes absence of running with 99% confidence level.Comment: 9 pages, EPHJA style, 4 figures, corresponds to published version with JADE author lis

Anthropic solution to the magnetic muon anomaly: the charged see-saw

We present models of new physics that can explain the muon g-2 anomaly in accord with with the assumption that the only scalar existing at the weak scale is the Higgs, as suggested by anthropic selection. Such models are dubbed "charged see-saw" because the muon mass term is mediated by heavy leptons. The electroweak contribution to the g-2 gets modified by order one factors, giving an anomaly of the same order as the observed hint, which is strongly correlated with a modification of the Higgs coupling to the muon.Comment: 21 pages, many equations despite the first word in the title. v3: loop function G_WN corrected, conclusions unchange

Exclusive processes in position space and the pion distribution amplitude

We suggest to carry out lattice calculations of current correlators in position space, sandwiched between the vacuum and a hadron state (e.g. pion), in order to access hadronic light-cone distribution amplitudes (DAs). In this way the renormalization problem for composite lattice operators is avoided altogether, and the connection to the DA is done using perturbation theory in the continuum. As an example, the correlation function of two electromagnetic currents is calculated to the next-to-next-to-leading order accuracy in perturbation theory and including the twist-4 corrections. We argue that this strategy is fully competitive with direct lattice measurements of the moments of the DA, defined as matrix elements of local operators, and offers new insight in the space-time picture of hard exclusive reactions.Comment: 15 pages, 10 figure

Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism

In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem-like cell (GSC) survival. Here, we show that PKCι is overexpressed and activated in patient derived GSCs compared with normal neural stem cells and normal brain lysate, and that silencing of PRKCI in GSCs causes apoptosis, along with loss of clonogenicity and reduced proliferation. Notably, PRKCI silencing reduces tumor growth in vivo in a xenograft mouse model. PKCι has been intensively studied as a therapeutic target in non-small cell lung cancer, resulting in the identification of an inhibitor, aurothiomalate (ATM), which disrupts the PKCι/ERK signaling axis. However, we show that, although sensitive to pharmacological inhibition via a pseudosubstrate peptide inhibitor, GSCs are much less sensitive to ATM, suggesting that PKCι acts along a different signaling axis in GSCs. Gene expression profiling of PRKCI-silenced GSCs revealed a novel role of the Notch signaling pathway in PKCι mediated GSC survival. A proximity ligation assay showed that Notch1 and PKCι are in close proximity in GSCs. Targeting PKCι in the context of Notch signaling could be an effective way of attacking the GSC population in GBM