Probing selectivity in recognition-mediated dynamic covalent processes

Two simple recognition-mediated dynamic Diels-Alder systems are used to probe the role of kinetics and thermodynamics in determining the equilibrium position in exchanging libraries and the time taken to reach that equilibrium. The selectivity expressed by recognition-driven dynamic processes is demonstrated to be less than the free-energy difference between the components as a result of compensatory effects arising from the extent of conversion to products within the library.</p

Probing selectivity in recognition-mediated dynamic covalent processes

Two simple recognition-mediated dynamic Diels-Alder systems are used to probe the role of kinetics and thermodynamics in determining the equilibrium position in exchanging libraries and the time taken to reach that equilibrium. The selectivity expressed by recognition-driven dynamic processes is demonstrated to be less than the free-energy difference between the components as a result of compensatory effects arising from the extent of conversion to products within the library.</p

METHOD FOR DETECTING POSITIONING AND ASSAYING OF BIOLOGICAL MOLECULES SEPARATED ON A SURFACE, BY MEASURING AN ELECTRICAL PROPERTY OR EFFECT

The invention concerns a method for detecting and quantifying at least an optionally marked biological molecule in a sample, comprising a step of eletrophoretic spatial dispersion of at least a molecule on a support, characterized in that it comprises (i) a step which consists in measuring the surface potential of said support, in each surface point of said support, using at least a probe

Recognition-Induced Facilitation of a Disfavoured Diels-Alder Cycloaddition

[GRAPHICS]The rational design of a system which is capable of accelerating and facilitating a thermodynamically disfavored Diets-Alder cycloaddition between a furan and a maleimide is presented. The origins of the acceleration and facilitation of the cycloaddition reaction are traced by kinetic studies-allied to results from H-1 NMR spectroscopy and X-ray crystallography-to the formation of strong intramolecular hydrogen bonds in the cycloadduct.</p

Recognition-Induced Facilitation of a Disfavoured Diels-Alder Cycloaddition

[GRAPHICS]The rational design of a system which is capable of accelerating and facilitating a thermodynamically disfavored Diets-Alder cycloaddition between a furan and a maleimide is presented. The origins of the acceleration and facilitation of the cycloaddition reaction are traced by kinetic studies-allied to results from H-1 NMR spectroscopy and X-ray crystallography-to the formation of strong intramolecular hydrogen bonds in the cycloadduct.</p