Teflon-packed flexible joint

Teflon-packed flexible joint separates the movement of the shaker from the liquid nitrogen hose during the ground testing of cryogenic zero-g equipment. The joint allows the hose to lie on the floor in a stationary position as the shaker moves back and forth, thus, the hose is not subject to violent motion

Neotropical Monogenoidea. 21. Trinigyrus mourei sp.n. (Dactylogyridae) from the gills of the Amazonian catfish Hypostomus marginatus (Loricariidae)

Trinigyrus mourei sp. n. (Dactylogyridae) is described from an Amazonian armoured catfish, Hypostomus emarginatus (Loricariidae) in Brazil. The new species closely resembles T. hypostomatis HANEK, MOLNAR & FERNANDO, 1974, from which it differs mainly by having: 1) a more robust copulatory organ; 2) a non-articulated accessory piece; and 3) comparatively longer haptoral appendages

Sur la présence de Mylesinus paraschomburgkii Jégu et al., 1989 (Characiformes, Serrasalmidae) dans le bassin du rio Jari (Brésil, Amapa)

Des récoltes postérieures à la description de #Mylesinus paraschomburgkii permettent d'étendre son aire de distribution au bassin du Jari et au principal affluent du Uatuma. Une analyse en composantes principales sur 18 descripteurs morphologiques montrent que la morphologie générale de la population du Jari est différente de celle des populations du Trombetas et du Uatuma. L'isolement de la population du Jari serait donc plus ancien que la séparation des populations du Trombetas et du Uatuma. La dispersion de #Mylesinus paraschomburgkii le long de la marge sud du plateau des Guyanes serait reliée aux transgressions marines du Quaternaire. (Résumé d'auteur

Searching for TeV DM evidence from Dwarf Irregular Galaxies with the HAWC Observatory

The dynamics of dwarf irregular (dIrr) galaxies are observed to be dominated by dark matter (DM). Recently, the DM density distribution has been studied for 31 dIrrs. Their extended DM halo (Burket type profile) makes these objects good candidates for DM searches. Located in Puebla (Mexico), the High Altitude Water Cherenkov (HAWC) Observatory is an optimal instrument to perform such DM searches, because of its large sky coverage (8.4 sr per day). We analyzed a set of two years of HAWC data and we found no significant DM signal from dIrr galaxies. We present the upper limits for DM annihilation cross-section with dIrr galaxies

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor relatively few established ‘driver’ lesions. Here, we describe a collection of genetically engineered mouse models (GEMMs) of sporadic CRC that combine lesions frequently altered in human patients, including well-characterized tumor suppressors and activators of MAPK signaling. Primary tumors from these models were profiled, and individual GEMM tumors segregated into groups based on their genotypes. Unique allelic and genotypic expression signatures were generated from these GEMMs and applied to clinically annotated human CRC patient samples. We provide evidence that a Kras signature derived from these GEMMs is capable of distinguishing human tumors harboring KRAS mutation, and tracks with poor prognosis in two independent human patient cohorts. Furthermore, the analysis of a panel of human CRC cell lines suggests that high expression of the GEMM Kras signature correlates with sensitivity to targeted pathway inhibitors. Together, these findings implicate GEMMs as powerful preclinical tools with the capacity to recapitulate relevant human disease biology, and support the use of genetic signatures generated in these models to facilitate future drug discovery and validation efforts

The use of TeleMedicine in the Treatment of Pediatric Obesity: Feasibility and Acceptability

This is the peer reviewed version of the following article: Davis, A. M., James, R. L., Boles, R. E., Goetz, J. R., Belmont, J. and Malone, B. (2011), The use of TeleMedicine in the treatment of paediatric obesity: feasibility and acceptability. Maternal & Child Nutrition, 7: 71–79. doi:10.1111/j.1740-8709.2010.00248.x, which has been published in final form at http://doi.org/10.1111/j.1740-8709.2010.00248.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.OBJECTIVE: To assess the feasibility of conducting empirically supported family based pediatric obesity group treatment via telemedicine. METHODS: Seventeen families were randomly assigned to one of two conditions (physician visit, TeleMedicine). Measures included feasibility, satisfaction, and intervention outcome measures such as BMI percentile, and nutrition and activity behaviors. Measures were completed at baseline, post-treatment, and at one-year follow-up. RESULTS: Analyses indicate that both feasibility and satisfaction data regarding the TeleMedicine intervention were positive. Intervention outcome indicates no change in BMI percentile or nutrition and activity behaviors for either treatment group. CONCLUSIONS: A behavioral family-based weight loss intervention delivered via TeleMedicine was well received by both parents and providers. Due to the small sample size, null findings regarding intervention outcome should be interpreted with caution. Future research should focus on methods to increase the impact of this intervention on key outcome variables

The use of cosmic muons in detecting heterogeneities in large volumes

The muon intensity attenuation method to detect heterogeneities in large matter volumes is analyzed. Approximate analytical expressions to estimate the collection time and the signal to noise ratio, are proposed and validated by Monte Carlo simulations. Important parameters, including point spread function and coordinate reconstruction uncertainty are also estimated using Monte Carlo simulations.Comment: 8 pages, 11 figures, submetted to NIM

Variability and spectral modeling of the hard X-ray emission of GX 339-4 in a bright low/hard state

We study the high-energy emission of the Galactic black hole candidate GX 339-4 using INTEGRAL/SPI and simultaneous RXTE/PCA data. By the end of January 2007, when it reached its peak luminosity in hard X-rays, the source was in a bright hard state. The SPI data from this period show a good signal to noise ratio, allowing a detailed study of the spectral energy distribution up to several hundred keV. As a main result, we report on the detection of a variable hard spectral feature (>150 keV) which represents a significant excess with respect to the cutoff power law shape of the spectrum. The SPI data suggest that the intensity of this feature is positively correlated with the 25 - 50 keV luminosity of the source and the associated variability time scale is shorter than 7 hours. The simultaneous PCA data, however, show no significant change in the spectral shape, indicating that the source is not undergoing a canonical state transition. We analyzed the broad band spectra in the lights of several physical models, assuming different heating mechanisms and properties of the Comptonizing plasma. For the first time, we performed quantitative model fitting with the new versatile Comptonization code BELM, accounting self-consistently for the presence of a magnetic field. We show that a magnetized medium subject to pure non-thermal electron acceleration provides a framework for a physically consistent interpretation of the observed 4 - 500 keV emission. Moreover, we find that the spectral variability might be triggered by the variations of only one physical parameter, namely the magnetic field strength. Therefore, it appears that the magnetic field is likely to be a key parameter in the production of the Comptonized hard X-ray emission.Comment: 14 pages, 9 figures, 3 tables, uses emulateApj.cls, accepted for publication in Ap

The AMS-02 RICH Imager Prototype - In-Beam Tests with 20 GeV/c per Nucleon Ions -

A prototype of the AMS Cherenkov imager (RICH) has been tested at CERN by means of a low intensity 20 GeV/c per nucleon ion beam obtained by fragmentation of a primary beam of Pb ions. Data have been collected with a single beam setting, over the range of nuclear charges 2<Z<~45 in various beam conditions and using different radiators. The charge Z and velocity beta resolutions have been measured.Comment: 4 pages, contribution to the ICRC 200

The Ring Imaging Cherenkov detector (RICH) of the AMS experiment

The Alpha Magnetic Spectrometer (AMS) experiment to be installed on the International Space Station (ISS) will be equipped with a proximity focusing Ring Imaging Cherenkov (RICH) detector for measuring the electric charge and velocity of the charged cosmic particles. A RICH prototype consisting of 96 photomultiplier units, including a piece of the conical reflector, was built and its performance evaluated with ion beam data. Preliminary results of the in-beam tests performed with ion fragments resulting from collisions of a 158 GeV/c/nuc primary beam of Indium ions (CERN SPS) on a Pb target are reported. The collected data included tests to the final front-end electronics and to different aerogel radiators. Cherenkov rings for a large range of charged nuclei and with reflected photons were observed. The data analysis confirms the design goals. Charge separation up to Fe and velocity resolution of the order of 0.1% for singly charged particles are obtained.Comment: 29th International Conference on Cosmic Rays (Pune, India