5,591 research outputs found

    Recent findings in bipolar affective disorder

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    Teaching a New Paradigm: Towards Rewarding Instruction for Librarian and Students

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    Library staff at the University of Victoria identified four main literacy instruction challenges - time, lack of student engagement, lack of relevancy to students, and lack of faculty awareness. They presented proposed solutions to address these issues. A handout was circulated and is included here

    Optimal trading strategies - a time series approach

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    Motivated by recent advances in the spectral theory of auto-covariance matrices, we are led to revisit a reformulation of Markowitz' mean-variance portfolio optimization approach in the time domain. In its simplest incarnation it applies to a single traded asset and allows to find an optimal trading strategy which - for a given return - is minimally exposed to market price fluctuations. The model is initially investigated for a range of synthetic price processes, taken to be either second order stationary, or to exhibit second order stationary increments. Attention is paid to consequences of estimating auto-covariance matrices from small finite samples, and auto-covariance matrix cleaning strategies to mitigate against these are investigated. Finally we apply our framework to real world data

    The need for psychiatric treatment in the general population: the Camberwell Needs for Care Survey

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    Background, This paper presents the first results of a two-stage psychiatric population survey, which uses a new method of directly evaluating needs for specific psychiatric treatment and the extent to which they have been met.Method, The sample was drawn at random from the population of an area of inner south London with high levels of deprivation. Seven hundred and sixty subjects aged 18-65 completed the GHQ-28. All those scoring > 5 and half of the rest were invited to take part in the second stage, comprising measures of mental state (SCAN), social role performance (SRPS), life events and difficulties (LEDS) and a Treatment Inventory. This information was used to rate the community version of the Needs for Care Assessment (NFCAS-C).Results, In all, 408 subjects were interviewed in the second stage. The weighted 1 month prevalence of hierarchically ordered ICD-10 psychiatric disorders was 9.8 %, the 1 year prevalence 12.3 %. The equivalent prevalences for depressive episode were 3.1 % and 5.3 % respectively, while those for anxiety states were both 2.8 %. At interview nearly 10% of the population were identified as having a need for the treatment of a psychiatric condition. This rose to 10.4 % if the whole of the preceding year was assessed. Less than half of all potentially meetable needs were met. There was only partial overlap between diagnosis and an adjudged need for treatment.Conclusion. A majority of people with mental health problems do not have proper treatment; given more resources and greater public and medical awareness, most could be treated by family doctors

    The psychosocial impact of bilateral prophylactic mastectomy: prospective study using questionnaires and semistructured interviews

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    OBJECTIVES: To investigate the psychosocial impact of bilateral prophylactic mastectomy for women with increased risk of breast cancer and to identify, preoperatively, risk factors for postoperative distress. DESIGN: Prospective study using interviews and questionnaire assessments. SETTING: Participants' homes throughout the United Kingdom. PARTICIPANTS: 143 women with increased risk of developing breast cancer who were offered bilateral prophylactic mastectomy and who accepted or declined the surgery; a further 11 were offered surgery but deferred making a decision. MAIN OUTCOME MEASURES: Psychological and sexual morbidity. RESULTS: Psychological morbidity decreased significantly over time for the 79 women who chose to have surgery (accepters): 58% (41/71) preoperatively v 41% (29/71) 6 months postoperatively (difference in percentages 17%, 95% confidence interval 2% to 32%; P=0.04) and 60% (39/65) preoperatively v 29% (19/65) 18 months postoperatively (31%, 15% to 47%; P<0.001). Psychological morbidity in the 64 women who declined surgery (decliners) did not decrease significantly: 57% (31/54) at baseline v 43% (23/54) at 6 months (14%, 0% to 29%; P=0.08) and 57% (29/52) at baseline v 41% (21/52) at 18 months (16%; -2% to 33%; P=0.11). Greater than normal proneness to anxiety was more common in the decliners than in the accepters: 78% (45/58) v 56% (41/73) (22%, 6% to 38%; P=0.006). Accepters were more likely than decliners to believe it inevitable that they would develop breast cancer (32% (24/74) v 10% (6/58) (difference in percentages 22%, 9% to 35%; P=0.003)), and decliners were more likely to believe that screening could help (92% (55/60) v 74% (55/74) (18%, 5% to 31%; P=0.007)). Level of sexual discomfort and degree of sexual pleasure did not change significantly over time in either of the two groups. CONCLUSIONS: Bilateral prophylactic mastectomy may provide psychological benefits in women with a high risk of developing breast cancer

    Extraction, Territory, and Inequalities: Gas in the Bolivian Chaco

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    Conflicts over extractive industry have emerged as one of the most visible and potentially explosive terrains for struggles over distribution, territory, and inequality in the Andes. We explore these relationships in Bolivia, focusing on gas extraction in the Chaco region of the southeastern department of Tarija. We consider how the expansion of extractive industry intersects with territorializing projects of state, sub-national elites, and indigenous actors as well as with questions of inequality and inequity. We conclude that arguments over the territorial constitution of Bolivia are inevitably also arguments over gas and the contested concepts of equity underlying its governance. © Canadian Journal of Development Studies, 2010. All rights reserved.This is an original manuscript of an article published by Taylor & Francis in Canadian Journal of Development Studies in 2010, available at https://www.tandfonline.com/doi/abs/10.1080/02255189.2010.966929

    Anatomy of a Regional Conflict: Tarija and Resource Grievances in Moraless Bolivia

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    In 2008, the Department of Tarija became the epicenter of national political struggles over political autonomy for lowland regions at odds with the Morales administration. In September, following a series of regional referenda on autonomy and a national recall election, citizen committees in Tarija mobilized urban-based sectors and organized a general strike against the central government. It is unhelpful to understand the strike as simply an act of political sabotage orchestrated by racist regional elites. The factors driving protest and interest in autonomy are varied and deeply related to patterns of hydrocarbons extraction in the department that have allowed for the mobilization of grievances and the cultivation of resource regionalism at departmental and intradepartmental scales. Alongside class and ethnicity, identities of place and region can be equally important in processes of mobilization, and the resonance of these spatialized identities is particularly important in resource-extraction peripheries. © 2010 Latin American Perspectives. Available download is the accepted version for publication

    Cannabis use and hypomania in young people: a prospective analysis

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    Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22–23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use. Results: Data were available on 3370 participants. Cannabis use at least 2–3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49–3.28) after adjustment. There was a dose–response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms. Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania
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