Predictive potencies of lung function and exercise variables for the presence of PH.

<p>Area under the curve (AUC) values and their confidence interval (95%-CI), sensitivity (SN), specificity (SP), positive (PPV) and negative predictive values (NPV) are given. Diagnostic cut offs in % predicted.</p

Lung function and gas exchange characteristics of the patient population.

<p>Comparison of IPF patients with and without PH. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065643#s3" target="_blank">Results</a> (median and 25^th; 75^th percentile) are given as absolute and % predicted values.</p

Survival of 133 patients with IPF with and without interceding pulmonary hypertension.

<p>Non-PH (blue line), PH (orange line).</p

Forest plot of meta-analyzed results for the effect per minor allele of rs3748312 on FEV1 in ever-smokers, adjusted for sex, age, height, population stratification factors and the presence of PI S and Z alleles.

<p>Studies based on population isolates with a high degree of cryptic relatedness are presented separately. Effect estimates of meta-analyses are shown with green diamonds. I² is a measure of the heterogeneity between studies. Random effect meta-analyses are included if I²>0.5. Study weights (blue squares) correspond to fixed effect meta-analyses.</p

Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level, conditional on PI S and PI Z alleles.

<p>Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level, conditional on PI S and PI Z alleles.</p

The ten most strongly associated SNPs in the unconditional GWAS on AAT serum level in SAPALDIA (N = 1392).

<p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r² is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r²<0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p

Minor allele effects of PI S, PI Z and rs4905179 on AAT serum levels in the Copenhagen City Heart Study.

<p>Abbreviations: MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p

The ten most strongly associated SNPs in the GWAS on AAT serum level, conditional on PI S and PI Z alleles in SAPALDIA (N = 1392).

<p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r² is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r²<0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p

LD plot among common and low-frequent SNPs in the <i>SERPINA1</i> gene within the SAPALDIA study.

<p>Shading represent r² values, whereas numbers represent D′ values (no number equals D′ = 1). Red framed SNPs are independently associated with AAT serum levels after forward selection stepwise regression modeling. Rs17580 is the PI S variant and rs28929474 is the PI Z variant.</p

Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level.

<p>SNPs reaching genome-wide significance are shown in green. They all belong to the <i>SERPINA</i> gene cluster.</p