Natural Coral as a Biomaterial Revisited

ABSTRACT: This paper first describes the state of the art of natural coral. The biocompatibility of different coral species has been reviewed and it has been consistently observed that apart from an initial transient inflammation, the coral shows no signs of intolerance in the short, medium, and long term. Immune rejection of coral implants was not found in any tissue examined. Other studies have shown that coral does not cause uncontrolled calcification of soft tissue and those implants placed under the periosteum are constantly resorbed and replaced by autogenous bone. The available studies show that the coral is not cytotoxic and that it allows cell growth. Thirdly, porosity and gradient of porosity in ceramics is explained based on far from equilibrium thermodynamics. It is known that the bone cross-section from cancellous to cortical bone is non-uniform in porosity and in pore size. Thus, it is hypothesized that a damaged bone containing both cancellous and cortical bone can be better replaced by a graded/gradient porous implant based on the idea of a biomimetic approach. The purpose of this article is to review and summarize all the pertinent work that has been published on natural coral as a bone graft during the last twenty years including in vitro, animal, and clinical human studies. In addition, as an illustration, we report the clinical experience of one of us using coral. It is a case study of complex femoral fracture (Table 1) where the essential role of vascularization and stabilization of the fracture site are underlined. The results are supported with more than 300 other femoral fractures treated using the same modus operandi. Finally, this paper overviews the ecological and ethical concerns around the use of corals as well as discussing briefly about recent impacts of nano-pollutants

Biocidal properties of copper nanoparticles

Metal nanoparticles (NPs) with antibacterial properties represent a promising alternative approach to antibiotics, whose overuse has led to the appearance of drug-resistant bacteria. This article addresses particularly copper (Cu) nanoparticles since Cu is a structural constituent of many enzymes in living microorganisms. In addition, Cu has a better antibacterial effect and minimal cost compared to silver. The properties of Cu nanoparticles are described here: antibactericide, toxicity mechanisms, oxidation, and copper oxide biocompatibility for medical applications. Along with the advantages of Cu nanoparticles, the nanotoxicity still remains to take into consideration such as in targetting different bacteria strains, bacteria’s resistance, the effect of size, the effect of NP chemical composition, the effect of oxidation, and the corona phenomenon effect. The methodology of Cu nanoparticles synthesis, related to the biocidal effect, is illustrated by some limitations and some breakthrough such as chitosan stabilizer (CS), laser ablation, plasma induction, and flow-levitation method (FL). Although Cu nanoparticles are beneficial for bacterial elimination, these nanoparticles are graded harmful to the human body and the environment because of their toxic effects. Thus, it requires further improvement and further investigation to create super antibacterial Cu nanoparticles, to develop some interesting research work around this subject, and to reveal some promising medical findings