Single nucleotide polymorphisms (SNPs) that were nominal significantly different in frequency between patients and controls.

<p>Data are adjusted for age and sex.</p

Demographics.

<p>Demographics.</p

Baseline clinical and laboratory data of 182 patients with non-diabetic chronic kidney disease stratified by GFR stages according to K/DOQI guidelines.

<p>GFR denotes glomerular filtration rate measured by iohexol clearance, BMI; body-mass index.</p><p>Data are presented as mean ± SD and 25^th, 50^th (median) and 75^th percentiles for skewed variables where appropriate.</p><p>P-values are for comparison across all four groups obtained from Kruskal-Wallis test, one-way ANOVA and χ² test where appropriate.</p

Baseline clinical and laboratory data of the 139 patients who completed follow-up and stratified by patient groups with and without progression of chronic kidney disease.

<p>GFR denotes glomerular filtration rate measured by iohexol clearance, BMI; body-mass index.</p><p>Data are presented as mean ± SD and 25^th, 50^th (median) and 75^th percentiles for skewed variables where appropriate.</p>a<p>P value for comparison between progressors and non-progressors.</p

Genetic association between iron and ferritin levels and haplotype-pairs in <i>SLC11A2</i> and <i>TMPRSS6</i> in SAPHIR.

<p><u>Notes</u>: For the haplotype pairs in <i>SLC11A2</i> and <i>TMPRSS6</i>, the regression was performed on all haplotype pairs in one model with the most probable haplotype pair as the reference. For the combined analysis, each line reflects the results from a regression model of this particular haplotype-pair versus all other pairs on the traits (each model sex- and age-adjusted). The p-values are based on the log-transformed model; the β-estimates are based on the model on the original scale.</p

SNP genotypes of the family within the two genes <i>SLC11A2</i> and <i>TMPRSS6</i>.

<p>SNP genotypes of the family within the two genes <i>SLC11A2</i> and <i>TMPRSS6</i>.</p

SNP genotyping results in SAPHIR (n = 1,726) and NBS (n = 1,832).

<p> <u>Notes:</u></p><p>The coding of genotypes is indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035015#pone-0035015-t002" target="_blank">Table 2</a>. SAPHIR data are indicated on the left side of the slash, and NBS data are given on the right side of the slash.</p><p>MAF… minor allele frequency.</p><p>CR… call rate (genotyping success rate).</p><p>HWE… p-value for test for Hardy-Weinberg-Equilibrium.</p

Genetic association between iron and ferritin levels and SNPs in <i>SLC11A2</i> and <i>TMPRSS6</i> in SAPHIR.

<p><u>Note</u>: For linear regression, an additive genetic effect of the SNPs on the outcome variable was assumed; linear regression analyses were adjusted for age and gender. The p-values were based on the log-transformed model, and the β-estimates were based on the model on the original scale.</p

Laboratory parameters of the family at the time of taking of the first blood samples, and after intravenous iron administrations in the family's children suffering from IRIDA, i.e. Son 2, and Daughters 1 and 2.

<p><u>Notes</u>:</p>a<p>If reference values are different for males (m) and females (f), both reference values are indicated.</p>b<p>Reference values can be found at <a href="http://www.hepcidinanalysis.com" target="_blank">www.hepcidinanalysis.com</a> (date of consulting the website: January 24, 2012);</p><p>n.a. not available.</p