A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours

FRM is funded by the Engineering and Physical Sciences Research Council (EPSRC).Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens by cells of the immune system, play a key role in the immune response against solid tumours. The existing mathematical models generally focus only on one of these key aspects. We present here a spatial stochastic individual-based model that explicitly captures antigen expression and recognition. In our model, each cancer cell is characterised by an antigen profile which can change over time due to either epimutations or mutations. The immune response against the cancer cells is initiated by the dendritic cells that recognise the tumour antigens and present them to the cytotoxic T cells. Consequently, T cells become activated against the tumour cells expressing such antigens. Moreover, the differences in movement between inactive and active immune cells are explicitly taken into account by the model. Computational simulations of our model clarify the conditions for the emergence of tumour clearance, dormancy or escape, and allow us to assess the impact of antigenic heterogeneity of cancer cells on the efficacy of immune action. Ultimately, our results highlight the complex interplay between spatial interactions and adaptive mechanisms that underpins the immune response against solid tumours, and suggest how this may be exploited to further develop cancer immunotherapies.PostprintPeer reviewe

EU kids online 2020 : survey results from 19 countries

EU Kids Online 2020: Survey results from 19 countries. This report maps the internet access, online practices, skills, online risks and opportunities for children aged 9–16 in Europe. Teams of the EU Kids Online network collaborated between autumn 2017 and summer 2019 to conduct a major survey of 25,101 children in 19 European countries.peer-reviewe

The role of smartphones in increasing digital and social inequalities among Romanian children

he emergence of new mobile devices such as Smartphones and tablets in children’s everyday life has facilitated the rise of Internet private use among them, making it possible for them to go online at anytime and anywhere. As studies show, ownership and private use of a Smartphone shape the quality of children’s online experience in a meaningful way (Mascheroni & Cuman, 2014). Accordingly, a broader range of access locations and devices relates to more unsupervised access and thus more independent use of the Internet, which are likely to be related to higher skill levels. This paper aims to investigate, using linear and multilinear regressions, whether owning or having access to Smartphones leads to increasing digital inequalities among children. Results show that demographic variables are significant predictors for the level of Smartphone related skills. However, when variables related with children’s Smartphone and Internet use are introduced in the model, the influence of demographic variables is reduced, showing evidence for second-level of digital divide among children. The present study reports on the Net Children Go Mobile dataset. The project collected data in 2013 from random stratified survey samples of around 500 children aged 9-16, who are Internet users, in seven European country, including Romania. For the purpose of this paper, only responses from Romanian children were taken into account (N=522)

Digital Natives or Not? How do Romanian Adolescents Cross the Boundaries of Internet Common Use

The present paper challenges the dominance of the digital natives’ agenda and turns its attention to the social context in which Internet usage among adolescents occurs. Findings indicate that even when young people are using the Internet with the same frequency, i.e. every day, the differences among them remain significant. Therefore, it can be argued that considering an entire cohort to be similar in terms of Internet use only due its age is a misconception. The way children make use of the Internet and the gratifications they gain after using it depend, as van Dijk (2005) showed, on the quality of access, on the level of skills, and on the personal (e.g. Experience, self-efficacy, confidence) and positional resources (e.g. Age, gender, socio-economic status). Questioning the main determinants that lead to the most advanced way to make use of the Internet, the logistic analysis shows that, in order for a Romanian adolescent to turn into an experienced user once he or she embedded the Internet in his or her everyday life, is a matter of skills, experience, and time online, and is less a matter of socioeconomic background. However, we have to keep in mind the previous path analysis’ findings, which emphasize that online experience, time spent online, self-efficacy, and digital skills are all determined, through direct or indirect effects, by demographic variables (i.e. age, gender and socio-economic status), even when age is held constant (Fizesan [Balea], 2012)

School Mediators in the Romanian Education System. A Discussion on Their Role in Addressing Educational Inequalities

Based on findings from the project ‘Socio-graphic mapping of the Roma Communities in Romania for a community-level monitoring of changes with regard to Roma integration’, the article analyses the role of school mediators in influencing school practices for the reduction of the inequalities Roma students face within the education system. This study investigates the school mediators’ perception of causes and solutions for the difficulties Roma students face within the education system, while keeping in mind the current legislation and the public discourse on Roma. In order to gain a comprehensive understanding, we also investigate school mediators’ perception towards their work, as well as the manner they evaluate collaboration with colleagues, Roma families and other local stakeholders. Our findings illustrate that the school mediator carries out a multitude of tasks sometimes only partly related to the field of school mediation. At the same time, school mediators engage in a type of public discourse with regard to Roma which highlights individual responsibility and merits as solutions in order to overcome disadvantage. With regard to work satisfaction, although school mediators are poorly trained and they deal with a difficult and high amount of work, they report being highly satisfied with some aspects of their work