Evaluation of extent of metastatic liver disease: A proposed discriminant

An attempt was made to predict the degree of metastatic liver involvement with the values of liver function tests obtained less than two months before death in 61 patients. Two mathematical models were tentatively used. The linear regression appeared to be unsuitable because lack of linearity was found after having adjusted the model to data. A discriminant function was calculated allowing proper redistribution into two anatomical groups ( 50% involvement) of 53 out of 61 patients. Implications for treatment and prognosis are briefly discussed. © 1971.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

L'autogreffe de moelle dans les hémopathies malignes. L'équipe de l'Unité Stérile.

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Complete remission following donor PBSC after low dose cytarabine chemotherapy for early relapse acute myelogenous leukemia after allogeneic stem cell transplantation

info:eu-repo/semantics/publishe

L'autogreffe de moelle dans les hémopathies malignes

avec l'équipe de l'Unité Stérileinfo:eu-repo/semantics/publishe

Treatment of brain giomas with high dose of CCNU and autologous bone marrow transplantation.

Seven patients with recurrent brain gliomas were treated by a single dose of CCNU 390 mg per m2. In five cases, chemotherapy was followed by autologous bone marrow transfusion containing 1.5 to 3 X 10(8) nucleated cells, 2.8 to 18 X 10(4) clusters plus colonies and 0.4 to 5 X 10(4) colonies forming cells per kg of body weight. Two patients were not grafted. None of these patients showed a clear cut response to the treatment as judged by clinical improvement and changes of the brain CT-scan. In 3 patients blood toxicity occurred early and was severe. In 4 others, it was milder and delayed. The duration and the severity of blood toxicity were modified by bone marrow transfusion but only slightly.Journal Articleinfo:eu-repo/semantics/publishe

Myeloid and lymphoid recovery following allogeneic bone marrow transplantation: a comparative study between related, unrelated bone marrow and allogeneic peripheral stem cell transplantation.

We studied myeloid and lymphoid recovery during a period of 12 months following HLA matched allogeneic bone marrow transplantation (BMT) in 15 patients. Patients were divided into three groups. Each group contained 5 patients according to the source of hematopoietic stem cell transplantation (HST): 1) related bone marrow transplantation (BMT), 2) allogeneic peripheral blood stem cell transplantation (PBSCT) and 3) matched unrelated donor transplantation (MUD). The rate and pattern of recovery of granulocytes, lymphocytes (T-cell subsets, B-cells, NK cells, subsets of CD45) were studied by cell counting and flow cytometry. Our results suggest faster recovery of PMN after PBSCT. Higher CD4 cell counts observed in the PBSCT group may have an impact on a lower incidence of opportunistic infections. Chronic GvHD mediated GvL effect seems to be more important in blood stem cell transplanted patients and this may have an influence on disease free survival.Comparative StudyJournal Articleinfo:eu-repo/semantics/publishe