Age-related distribution of endocrine cells in the human prostate: a quantitative study.

A morphometric analysis was performed to obtain quantitative data on age-related changes in prostatic endocrine cell (PrEC) density. Sixty prostates from subjects aged 14-74 years were studied with a semi-automatic image analysis system (ASM 68K, Leitz) applied to sections immunostained for chromogranin A-reactive cells. The highest density of PrECs (0.366 cells/mm of epithelial length) was found in the 25-54 year age group, which was significantly different from that found in prostates of the younger (0.311 cells/mm) and the older (0.261 cells/mm) age groups. The data probably reflect the higher incidence of incompletely developed glandular units in the younger group and the formation of new alveoli related to the usual glandular hyperplasia that occurs with increasing age in the older group

Pathological findings in perinatal autopsies

The study of perinatal mortality rates has recently be entered by pathologists, because of their capacity to discover the true cause of death at necroscopy

Carcinoma e cheratosi orale

Monografia con lo scopo di formare studenti e laureati in Medicina e Chirurgia, Odontoiatria, specialisti di Odontostomatologia e di Anatomia patologica, all'attuazione di una diagnosi di lesione precancerosa e di una diagnosi precoce di carcinoma oral

Antithrombotic activity of a 2-kDa heparin fragment in an experimental model of carotid artery thrombosis in rats

The antithrombotic activity of a 2-kDa heparin fragment was studied in a rat model of common carotid artery thrombosis that causes a completely occlusive thrombus with cessation of the blood flow within 10-15 min. The compound reduced thrombus formation in a dose-dependent manner, starting from an intravenous dose of 5 mg kg(-1). A dose of 20 mg kg(-1) completely prevented thrombus formation and apparently induced the almost complete lysis of the already formed occlusive thrombus. At none of the doses used did the compound cause increased bleeding or the formation of haematomas. The present results indicate that low molecular weight heparins, which have an established, highly beneficial effect in venous thromboembolism, are also highly effective in an animal model of arterial thrombosis

Morphological, histochemical and immunocytochemical study of CO2 and Er:YAG laser effect on oral soft tissues

The purpose of this study was to investigate the morphological, histochemical, and immunocytochemical changes of the oral mucosa after CO2 or Er:YAG laser irradiation. Background Data: There have been no comparative reports on CO2 and Er:YAG laser effects on human oral soft tissues. Materials and Methods: Tissue preservation was studied in 40 oral biopsies of young patients obtained by CO2 and Er:YAG laser surgery. Hematoxylin-eosin and Giemsa stains, PAS/diastase treatment, AE1 and AE2 cytokeratins, MiB1/Ki67, and bcl-2 immunoreactions were performed on the laser cut edges on formalin fixed, paraffin embedded biopsies. Results: CO2 laser biopsies show blisters, clefts and erosions of the epithelium. Intracellular edema and lengthened nuclei were also seen. The glycogen content results decreased in CO2 laser biopsies. Good expression for cytokeratins and cell-cycle proliferation markers were found in Er:YAG biopsies, on the contrary the apoptosis marker was better expressed in CO2 laser biopsies. Conclusion: The results suggest that Er:YAG laser may be routinely used in surgery, because of its minimal damage of the epithelial tissue, its low inflammatory reaction, its quicker healing process and its lower risk of scarring

Combined technique with polyethylene fibers and composite resins in restoration of traumatized anterior teeth

Traumatized anterior teeth need quick esthetic and functional repair. Esthetic requirements of anterior teeth require the use of composite materials which, in the most complex cases, can be used in association with fibers so as to improve their mechanical resistance. Many kinds of fibers are available. The authors considered parameters such as physical properties, water absorption, ease of cutting and of laying. Polyethylene fibers appear to have the best properties in elasticity, translucency, adaptability, tenaciousness, resistance to traction and to impact. Fifteen children, between 7 and 13 years old, with crown fractures of the anterior sector were treated. In the case of a simple crown fracture, the missing part was restored by polyethylene fibers and composite resins. In the case of a complex crown fracture needing endodontic treatment, the fibers were used as a central core stump in order to restore the dental morphology. At control examinations, the teeth restored by this technique were acceptable, both in function and in aesthetics. Thus, the authors recommend this combined technique for predictable restoration of traumatized anterior teeth