89 research outputs found
Detection of proton tracks with LiF Fluorescent Nuclear Track Detectors
Fluorescent nuclear track detectors based on LiF crystals were successfully
applied for detection of proton induced tracks. Irradiations were performed
with protons with energy ranging from 1 MeV up to about 56 MeV and for all
proton energies the fluorescent tracks were observed. The tracks are not
continuous, but consist of a series of bright spots. The gaps between spots
tend to narrow with decreasing proton energy (increasing ionization density).
For the highest of the studied energies, the spots are scattered so sparsely,
that it is not possible to link spots belonging to one track. The intensity
(brightness) of the fluorescent tracks increases with the increasing LET and
agrees well with the trend established earlier for various heavier ions.Comment: 12 pages, 12 figure
D-Ribose Induces Cellular Protein Glycation and Impairs Mouse Spatial Cognition
BACKGROUND: D-ribose, an important reducing monosaccharide, is highly active in the glycation of proteins, and results in the rapid production of advanced glycation end products (AGEs) in vitro. However, whether D-ribose participates in glycation and leads to production of AGEs in vivo still requires investigation. METHODOLOGY/PRINCIPAL FINDINGS: Here we treated cultured cells and mice with D-ribose and D-glucose to compare ribosylation and glucosylation for production of AGEs. Treatment with D-ribose decreased cell viability and induced more AGE accumulation in cells. C57BL/6J mice intraperitoneally injected with D-ribose for 30 days showed high blood levels of glycated proteins and AGEs. Administration of high doses D-ribose also accelerated AGE formation in the mouse brain and induced impairment of spatial learning and memory ability according to the performance in Morris water maze test. CONCLUSIONS/SIGNIFICANCE: These data demonstrate that D-ribose but not D-glucose reacts rapidly with proteins and produces significant amounts of AGEs in both cultured cells and the mouse brain, leading to accumulation of AGEs which may impair mouse spatial cognition
Chemical vapour deposition synthetic diamond: materials, technology and applications
Substantial developments have been achieved in the synthesis of chemical
vapour deposition (CVD) diamond in recent years, providing engineers and
designers with access to a large range of new diamond materials. CVD diamond
has a number of outstanding material properties that can enable exceptional
performance in applications as diverse as medical diagnostics, water treatment,
radiation detection, high power electronics, consumer audio, magnetometry and
novel lasers. Often the material is synthesized in planar form, however
non-planar geometries are also possible and enable a number of key
applications. This article reviews the material properties and characteristics
of single crystal and polycrystalline CVD diamond, and how these can be
utilized, focusing particularly on optics, electronics and electrochemistry. It
also summarizes how CVD diamond can be tailored for specific applications,
based on the ability to synthesize a consistent and engineered high performance
product.Comment: 51 pages, 16 figure
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