Effects of Unilateral and Bilateral Epididymectomy on Testes of Rats

It is generally agreed that the testis is under endocrine control from the pituitary, and is influenced by physiological and paracrine factors within the organ.The aim of this study is to analyze the effect of unilateral and bilateral epididectomy on the testicular tissue growth of rats.Twenty- one male old Sprague-Dawley rats (28 days old) were used in the study. Rats were assigned into 3 equal groups. The first group was the control group, while unilateral and bilateral epididectomy was performed on the second and third groups, respectively. Twenty-one days after the epididectomy, testicular tissues from each group were taken and fixed in Bouin solution. Paraffin sections were stained with Haematoxylin and Eosin, Vangiesson, PAS-Hemalun and examined by light microscopy.Disorganization of the germinal epithelium, desquamation, degeneration and edema in interstitial tissue was seen in the testicular cross sections of the unilateral group. Arrest in spermatozoon stage in some tubules and presence of eosinophylic stained multinucler bodies were recognizable. In the bilateral group, degeneration and atrophic status in the seminiferous tubules of the bilateral group was observed preciesly, and occasional interstitial edema and perforations in the basal lamina were recognizable. In addition, vasodilatation, arrest in spermatozoa stage and multinucleated bodies in some of the seminiferous tubules lumen were observed in some testicular cross sections of this group.As a result, epididectomy causes degeneration in the germinal epithelium and hypoplasia in Leydig cells.It is concluded that epididectomy causes degeneration in the germinal epithelium, interruption of spermatogenesis, and a notable decrease in the number of Leydig cells

Interaction between the success level of Turkish teaching courses and attitude and metacognitive skills

Bu araştırma, Eğitim Fakültesi ilköğretim Bölümü Sınıf Öğretmenliği Anabilim Dalında öğrenim gören öğrencilerin Türkçe Öğretimi dersi akademik başarı düzeyi üzerinde tutum ve üst bilişsel becerilerin etkisi, bazı değişkenlerle ilişkisi ve etkileşimini belirlemeyi amaçlamaktadır. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırma, 2011-2012 Öğretim Yılı Bahar Dönemi Trakya Üniversitesi ve Kocaeli Üniversitesi Eğitim Fakültesi ilköğretim Bölümü Sınıf Öğretmenliği Anabilim Dalı 3.sınıfta öğrenim gören ve Türkçe Öğretimi dersini alan toplam 214 öğrenci ile yapılmıştır. Araştırmada, araştırmacı tarafından geliştirilen “Üstbilişsel Beceri Ölçeği” ve “Türkçe Öğretimi Dersi Tutum Ölçeği” kullanılmış ayrıca; öğrencilerin Türkçe Öğretimi dersi dönem sonu akademik başarı notları kullanılarak veriler elde edilmiştir. Veriler Mann Whitney-U Testi, Kruskal Wallis H-Testi, Sperman korelasyon ve regrasyon tekniği ile analiz edilmiştir.Araştırmadan elde edilen bulgulara göre, Türkçe Öğretimi dersine ilişkin tutum düzeyi ile cinsiyet ve anne eğitim durumu değişkeni grup puanlarına göre dağılımı arasında; üstbilişsel beceri düzeyi ile cinsiyet ve müstakil çalışma odası değişkeni grup puanlarına göre dağılımı arasında ve Türkçe Öğretimi dersine ilişkin akademik başarı düzeyi ile cinsiyet değişkeni grup puanlarına göre dağılımı arasında anlamlı bir fark olduğu belirlenmiştir. Türkçe Öğretimi dersine ilişkin akademik başarı düzeyi ile tutum düzeyi, Türkçe Öğretimi dersine ilişkin akademik başarı düzeyi ile üstbilişsel beceri düzeyi ve üstbilişsel beceri düzeyi ile tutum düzeyi arasında pozitif yönde anlamlı bir ilişki olduğu belirlenmiştir. Türkçe Öğretimi dersine ilişkin akademik başarı düzeyinin tutum düzeyinden ve üstbilişsel beceri düzeyinden etkilenme durumunun anlamlı olduğu belirlenmiştir. Ayrıca, Türkçe Öğretimi dersine ilişkin tutum düzeyinin akademik başarı ile üstbilişsel beceri düzeyinin etkileşimine anlamlı bir etkisinin olmadığı belirlenmiştir.AbstractThis study intends to see into the effect(s) of attitude and metacognitive skills on the academic success level of Turkish teaching courses for the students that study Elementary Teacher Program in the Faculty of Education, as well as its correlation and interaction with certain variables. Relational screening model has been used in the research. The research has been conducted with 214 students studying in 3rd grade of Elementary School Teaching Program and Turkish Teaching Program in 2011-2012 Spring Semester in the Faculty of Education of Trakya University and of Kocaeli University. “Metacognitive Skill Scale” and “Turkish Teaching Course Attitude Scale”, developed by the researcher, have been used in this study. Besides, data has been obtained by using students' end-of-term academic final grades for Turkish Teaching lesson. Data has been analyzed by Mann Whitney-U Test, Kruskal Wallis H-Test, Spearman correlation and regression technique.According to findings obtained by research, it has been determined that there is a significant difference between attitude level related to Turkish Teaching and distribution by group points of variance of sexuality and mother's educational status; between metacognitive skill level and distribution by group points of variance of sexuality and detached workroom and between academic success level related to Turkish Teaching and distribution by group points of variance of sexuality. It has been determined that there is a meaningful relationship in a positive way between academic success level related to Turkish Teaching lesson and attitude level; between academic success level related to Turkish Teaching lesson and metacognitive skill level and between metacognitive skill level and attitude level. It has been determined that academic success level related to Turkish Teaching is significantly affected by attitude level and metacognitive skill level. Besides, it has been determined that attitude level related to Turkish Teaching lesson has no significant effect on interaction of academic success and metacognitive skill level

Biochemical biomarkers for detection of nephrotoxicity and cardiotoxicity in cisplatin administered rats

Objective: Cisplatin is a widely used anticancer drug. The aim of this study is to investigate biochemical biomarkers that can be used for identification of cisplatin cardiotoxicity and nephrotoxicity. Methods: This study was conducted on female Wistar Albino rats weighing 200-300 g. Rats were seperated into two groups as cisplatin administered group (n=5) and the control group (n=6). Intraperitoneal cisplatin (cumulative dose 16 mg/kg) was administered to the first group and the second group received physiological serum. All rats were sacrificed on day 14 of the study. BNP, troponin I, CK MB, urea, creatinine levels were measured in rat blood samples. All blood samples were stored at -80 degrees C until measurement. Results: Troponin I, urea and creatinine concentrations of cisplatin administered rats were signicantly higher from those of the control rats. Conclusion: Urea and creatinine values may be used for identification of cisplatin nephrotoxicity and troponin I may be a good biomarker for detection of cisplatin cardiotoxicity

Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200-250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue