A STUDY OF ENGLISH LISTENING STRATEGIES APPLIED BY ENGLISH NON-MAJORED STUDENTS AT TAY DO UNIVERSITY, VIETNAM

Listening comprehension is one of the important skills for learning a foreign language. Among four basic skills in language leaning, many researchers say that listening skill is applied the most frequently. Therefore, strategies for listening comprehension and the ability to employ them effectively are indispensable in language learning. This paper was an attempt to investigate the listening strategies employed by English non-majored students at Tay Do University. A total of 64 students of two different majors at the university participated in this study to answer a widely used language learning strategy questionnaire. The questionnaire consists of 31 questions including metacognitive strategies, cognitive strategies, social and affective strategies. The data were analyzed by SPSS 11.5 program. The findings indicated that most students applied listening strategies with different degrees and they needed guidance from their instructors. Moreover, the study also presents the relationships among these listening strategies. Finally, the results of this study provide implications for improving the quality of teaching and learning listening skill in the Vietnamese context. Article visualizations

Comprehensive molecular characterization of urothelial bladder carcinoma

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomasto provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell-cycle regulation, chromatin regulation, and kinase signalling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in microRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the phosphatidylinositol-3-OH kinase/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalitiesclose27