Association of vitamin D receptor (FOKI, TAQI, APAI & BSMI) and IF-y genes' polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population

Almost one third of the world's population is infected with Mycobacterium tuberculosis (MTB) and only 10% of them will develop any active form of the disease. TB is second (1s t is HIV/AIDS) greatest killer worldwide due to a single infectious agent. In 2012, 8.6 million people developed active TB and 1.3 million died. Over 95% of TB deaths occur in developing countries. In 2012, an estimated more than half million children became ill with TB and 74 000 of them died. The TB cases are declining annually, but very slowly. Multi-drug resistant TB (MDR-TB) and extensively drug-resistant tuberculosis (XDRTB) is present in almost all surveyed countries. Kazakhstan is not highly burdened by TB. Kazakhstan is the list of MDR-TB and XDR-TB burden countries. Our aim is to investigate an association of Vitamin D receptor (FokI, TaqI, ApaI & BsmI) and IF-y genes" polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population

Whole genome sequencing of mycobacterium tuberculosis in Kazakhstan: first sequence results of two clinical isolates

The project is aimed to create the prerequisites for a personalized approach to the diagnosis and treatment of tuberculosis (TB) by identifying and comparing the whole genome sequences of M.tuberculosis strains isolated in Kazakhstan. Analysis for whole genome sequences obtained using the next generation sequencing technology will clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance

Mapping of eco-social and genetic factors of susceptibility of tuberculosis among the population of the Rebuplic of Kazakhstan

In this study combined design was used, which included: 1) Case-control study; 2) Molecular epidemiological study; and 3) Study of human genetic susceptibility to tuberculosis.This work is the first case-control study in Kazakhstan where complex factors of TB risk and their effects are estimated. The study confirmed the role of main risk factors of tuberculosis development in Kazakhstan: young age, single relationship status, living in rent apartment, smoking, diabetes and migration

Genetic architecture of Kazakh population

The aim of the project is to define genetic architecture of Kazakh population by sequencing and analyzing whole exomes and whole genomes of Kazakhs living in different regions of Kazakhsta

Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis

The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance, which will pave the personalized approach in the diagnosis and treatment of TB

Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis

The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance, which will pave the personalized approach in the diagnosis and treatment of TB