Estudio de mercado de extintores en Pereira y Dosquebradas

Debido a que el potencial de ventas del producto tradicional para una empresa metalmecánica, ubicada en el departamento de Risaralda, ha disminuido drásticamente, se buscaron nuevas alternativas, entre las cuales se identificó el extintor como una de las más viables técnicamente, por lo que se realizó un estudio de mercados en el que se analizó el comportamiento de los compradores mayoristas de este producto, en el área metropolitana de Pereira y Dosquebradas. Para ello, se llevó a cabo la aplicación y tabulación de una encuesta a la totalidad del mercado objetivo, con el fin de identificar factores relevantes frente a la demanda, precio, promoción y competencia, para llegar así a las conclusiones de los objetivos planteados y realizar recomendaciones a la empresa, encaminadas a desarrollar estrategias con la información procesada.Due to the decrease of sales potential from the traditional product for a metal mechanic company located in the department of Risaralda, Colombia, has declined dramatically, new product alternatives were sought, including the extinguisher as one of the most technically feasible, so a market study was conducted, in which was analyzed the behavior of wholesale buyers of this product in the metropolitan area of Pereira and Dosquebradas, through the application and tabulation of a survey of the entire target market, in order to identify relevant factors about demand, price, promotion, competitors and reach conclusions related to the objectives and make recommendations to the company aimed at develop strategies with the processed information

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality