Phytochemical and Pharmacological potential of Annona cherimola-A Review

Several plant remedies have been employed in various medicinal systems for the treatment and management of different diseases. During past several years, there has been growing interest among the usage of various medicinal plants from traditional system of medicine for the treatment of different ailments. Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Annona cherimola Miller is a multipurpose tree with edible fruits and is one of the sources of the medicinal products. This review attempts to encompass the available literature on Annona cherimola with respect to its pharmacognostic characters, phytochemical constituents, pharmacological activities and traditional uses

Qualitative Analysis and Antibacterial Activity of Pelargonium graveolenL’Herit

Medicinal plants are an important source of phytochemicals that offer traditional medicinal treatment of various ailments and one of the plants is Pelargonium Graveolens which was grown in Hyderabad province. The preliminary screening of their aerial leaves showed best results the presence of different phytochemical like alkaloids, flavonoids, glycosides, phenol, sterol and lignin found in Methanolic and Ethyl acetate extract. However chloroform extract revealed the absence of alkaloids and sterols, where as in Water extract flavonoids, phenol, sterol and lignin. The best resulted extracts from preliminary screening test were subjected to Antimicrobial studies like some on gram positive and gram negative bacterial strains which exhibited a significant effect.  The both ethyl acetate  and methanolic extracts were showed the similar zone of inhibition on gram positive bacteria (S.aurea and B.Subtilus) whereas  ethyl acetate  extract positive inhibition on k.pneumonia  when compare to methanolic  extract  and which are more active suppression on gram negative  bacterial (E.coli) in comparison with the standard antibiotic.

Qualitative Analysis and Antibacterial Activity of Pelargonium graveolenL’Herit

Medicinal plants are an important source of phytochemicals that offer traditional medicinal treatment of various ailments and one of the plants is Pelargonium Graveolens which was grown in Hyderabad province. The preliminary screening of their aerial leaves showed best results the presence of different phytochemical like alkaloids, flavonoids, glycosides, phenol, sterol and lignin found in Methanolic and Ethyl acetate extract. However chloroform extract revealed the absence of alkaloids and sterols, where as in Water extract flavonoids, phenol, sterol and lignin. The best resulted extracts from preliminary screening test were subjected to Antimicrobial studies like some on gram positive and gram negative bacterial strains which exhibited a significant effect.  The both ethyl acetate  and methanolic extracts were showed the similar zone of inhibition on gram positive bacteria (S.aurea and B.Subtilus) whereas  ethyl acetate  extract positive inhibition on k.pneumonia  when compare to methanolic  extract  and which are more active suppression on gram negative  bacterial (E.coli) in comparison with the standard antibiotic.

Anti-cancer activity of crude Slrp protein conjugated mesoporous silica nanoparticles in HeLa Cell Lines: An in vitro approach

Microbial based therapeutics for cancer have gained a significant interest in recent decades. The present study relies on the synthesis, analysis, and conjugation of Salmonella Leucine-rich Proteins (SlrP) with mesoporous silica nanoparticles (MSNN) to evaluate their potential anticancer activity. The SlrP proteins were effectively produced and isolated from Salmonella enterica using Tryptic Soy Broth (TSB), and the subsequent SDS-PAGE analysis verified the presence of a band at around 72 KDa. The MSN synthesis yielded particles with an average diameter of 68.05±0.87 nm and a pore diameter of 7.1 nm.   In addition, we synthesized MSNMPA and then conjugated them with SlrP. Characterization studies confirmed the effective conjugation. The cytotoxicity evaluation conducted on HeLa cells revealed no substantial modification in cell viability upon treatment with MSN alone. Nevertheless, when MSNMPA/SlrP was done, it demonstrated significant cytotoxic properties, as evidenced by an IC50 value of 10 µg/mL. The results indicate that SlrP-conjugated MSN (MSNMPA/SlrP) could be utilized as promising nanocarriers for delivering anticancer proteins.

Phytochemical analysis, anti-oxidant and anti-microbial activity of Acalypha indica leaf extracts in different organic solvents

The herb Acalypha indica which belongs to Euphorbiaceae family has multiple medicinal properties which include anti-oxidant, anti-bacterial, anti-fungal, anti-inflammatory, antiulcer, anti-helmintic, anti-cancerous, anti-venom, and neuro-protective activity. The present study was designed to evaluate the phytochemical, antimicrobial and anti-oxidant activity of Acalypha indica leaves extracts in different solvent extractions like methanol, hexane, ethyl acetate and petroleum ether. Fresh leaves of the plant were collected and shade dried. Dried leaves were milled to obtain powder. Powder was subjected to soxhlet extraction using solvents and extracts were successively obtained. Phytochemical analysis was conducted following standard methods.  Phytochemical analysis showed the presence of Alkaloids, Phenols, Saponins, Flavanoids and Amino acids. Leaf extract of methonal have shown the highest anti-oxidation capacity than hexane, ethyl acetate and petroleum ether. Anti-microbial activity has been performed on microbes like Bacillus sps, E.coli, Psuedomonas sps and Streptococcus sps. A highest value of zone of inhibition was found in methanol extract against E.coli. These results provide evidence that Acalypha indica leaf extract possesses vital phytochemicals, antimicrobial and antioxidant properties. Hence this plant can be studied further for drug analysis for finding potent medicines for diseases

Phytochemical analysis and antibacterial activity of Gymnema sylvestre leaf extracts

During the last decade, the use of traditional medicine has expanded globally and is gaining popularity. Traditional medicines are used not only for primary health care of the poor in developing countries, but also in countries where conventional medicine is predominant in the national health care system. The herbal medicines serve the health needs of about 80% of the world’s population. Gymnema sylvestre is an herb native to the tropical forests of southern and central India and Sri Lanka. It belongs the family Asclepiadaceae. Chewing the leaves suppresses the sensation of sweet. This effect is attributed to the presence of the compound named as gymnemic acids. The results of present study clearly indicate the presence of different phytochemical compounds and antibacterial activity of the aqueous and methanolic extracts of leaves. The active compound of the plant is a group of acids termed as gymnemic acid. Secondary metabolites like alkaloids, terpenoids, phenolics, steroids and flavonoids play an important role in the plant activities. Presence of these compounds of plant which could be of considerable interest to the development of new drugs

Phytochemical analysis and antibacterial activity of Gymnema sylvestre leaf extracts

During the last decade, the use of traditional medicine has expanded globally and is gaining popularity. Traditional medicines are used not only for primary health care of the poor in developing countries, but also in countries where conventional medicine is predominant in the national health care system. The herbal medicines serve the health needs of about 80% of the world’s population. Gymnema sylvestre is an herb native to the tropical forests of southern and central India and Sri Lanka. It belongs the family Asclepiadaceae. Chewing the leaves suppresses the sensation of sweet. This effect is attributed to the presence of the compound named as gymnemic acids. The results of present study clearly indicate the presence of different phytochemical compounds and antibacterial activity of the aqueous and methanolic extracts of leaves. The active compound of the plant is a group of acids termed as gymnemic acid. Secondary metabolites like alkaloids, terpenoids, phenolics, steroids and flavonoids play an important role in the plant activities. Presence of these compounds of plant which could be of considerable interest to the development of new drugs