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The effects of high strain-rate and in-plane restraint on quasi-statically loaded laminated glass: a theoretical study with applications to blast enhancement
Abstract: Laminated glass panels are increasingly used to improve the blast resilience of glazed facades, as part of efforts to mitigate the threat posed to buildings and their occupants by terrorist attacks. The blast response of these ductile panels is still only partially understood, with an evident knowledge gap between fundamental behaviour at the material level and observations from full-scale blast tests. To enhance our understanding, and help bridge this gap, this paper adopts a ‘first principles’ approach to investigate the effects of high strain-rate, associated with blast loading, and the in-plane restraint offered by blast-resistant frames. These are studied by developing simplified analytical beam models, for all stages of deformation, that account for the enhanced properties of both the glass and the interlayer at high strain-rates. The increased shear modulus of the interlayer results in a composite bending response of the un-fractured laminated glass. This also enhances the residual post-fracture bending moment capacity, arising from the combined action of the glass fragments in compression and the interlayer in tension, which is considered negligible under low strain-rates. The post-fracture resistance is significantly improved by the introduction of in-plane restraint, due to the membrane action associated with panel stretching under large deflections. This is demonstrated by developing a yield condition that accounts for the relative contributions of bending and membrane action, and applying the upper bound theorem of plasticity, assuming a tearing failure of the interlayer. Future work aims to complete the theoretical framework by including the assessment of plate-action and inertia effects
Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab′ fragment (99mTc-DI-DD3B6/22-80B3): results of a phase I trial
Purpose 99mTc-DI-DD3B6/22-80B3 (ThromboView®, hereafter abbreviated to 99mTc-DI-80B3 Fab′) is a radiolabelled humanised monoclonal Fab′ fragment with affinity and specificity for D-dimer domains of cross-linked fibrin. Detection of thromboembolic events has been demonstrated in canine models. The study objectives were evaluation of safety and characterisation of biodistribution, immunogenicity and pharmacokinetic profile of increasing doses of 99mTc-DI-80B3 Fab′ in subjects with acute lower-limb DVT. Methods Twenty-six patients with acute lower limb DVT were enrolled. Of these, 21 received a single intravenous dose of 0.5 mg (n = 6), 1.0 mg (n = 9) or 2 mg (n = 6) 99mTc-DI-80B3 Fab′. Blood and urine samples and gamma camera images were collected to 24 h after administration for pharmacokinetic and dosimetry analysis. Vital signs, electrocardiography, hematological and biochemical data and human anti-human antibody (HAHA) levels were monitored for up to 30 days following administration. Patients were assigned to either planar or single photon emission computed tomographic (SPECT) imaging of the thorax at 4 h following injection. Results Thirty-five adverse events were reported in 15 of the 21 subjects. Those deemed possibly related to administration of 99mTc-DI-80B3 Fab′ included mild hypertension, mild elevation of LD (lactate dehydrogenase) and moderate elevation of ALT (alanine transaminase). HAHA assays remained negative. Pharmacokinetics and organ dosimetry were comparable to prior normal volunteer data. Localisation of Thromboview® to sites of known thrombus was evident as early as 30 min post-injection. Conclusions In subjects with acute DVT, 99mTc-DI-80B3 Fab′ was well tolerated with favourable characteristics for the detection of acute venous thrombosis