10 research outputs found

    Detailed curation of an interaction in HSC-Explorer.

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    <p>Information about the interaction between ‘Tie2/Ang1 signaling’ and the term ‘quiescence’ consists of (a) ‘General information’ about the organism used in the experiment and reference, (b) textual information (‘Comment’) about the interaction and experimental procedure, and (c) structured information including in addition information about the hematopoietic cell-type.</p

    Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate-2

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    <p><b>Copyright information:</b></p><p>Taken from "Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate"</p><p>http://www.biomedcentral.com/1471-2164/8/190</p><p>BMC Genomics 2007;8():190-190.</p><p>Published online 25 Jun 2007</p><p>PMCID:PMC1929077.</p><p></p>total of 1932 (60%) ESTs were assigned a gene name, 610 (19%) contained a partial ORF, 642 (20%) were mappable to a genome but could not be assigned a gene name and 31 (1%) could not be mapped. . Pie chart indicating the origin of the marmoset sequences represented on the marmoset microarray. Of the in total 1541 marmoset transcripts represented on the array the majority (1445 = 95%) were derived from the set of 3215 marmoset ESTs submitted to GenBank. The remaining 5% consisted of 68 pre-existing marmoset sequences already present in GenBank and 28 ESTs from the hippocampal cDNA library that were not submitted to GenBank. The 1445 submitted ESTs could be subdivided into a group of 886 (58%) that were assigned a gene name, 364 (24%) with a (partial) ORF, 188 (12%) that were mappable but without a gene name or an ORF and 7 (0%) that were not mappable

    Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate-1

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    <p><b>Copyright information:</b></p><p>Taken from "Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate"</p><p>http://www.biomedcentral.com/1471-2164/8/190</p><p>BMC Genomics 2007;8():190-190.</p><p>Published online 25 Jun 2007</p><p>PMCID:PMC1929077.</p><p></p>y the correlation coefficient

    Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate-0

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    <p><b>Copyright information:</b></p><p>Taken from "Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate"</p><p>http://www.biomedcentral.com/1471-2164/8/190</p><p>BMC Genomics 2007;8():190-190.</p><p>Published online 25 Jun 2007</p><p>PMCID:PMC1929077.</p><p></p>total of 1932 (60%) ESTs were assigned a gene name, 610 (19%) contained a partial ORF, 642 (20%) were mappable to a genome but could not be assigned a gene name and 31 (1%) could not be mapped. . Pie chart indicating the origin of the marmoset sequences represented on the marmoset microarray. Of the in total 1541 marmoset transcripts represented on the array the majority (1445 = 95%) were derived from the set of 3215 marmoset ESTs submitted to GenBank. The remaining 5% consisted of 68 pre-existing marmoset sequences already present in GenBank and 28 ESTs from the hippocampal cDNA library that were not submitted to GenBank. The 1445 submitted ESTs could be subdivided into a group of 886 (58%) that were assigned a gene name, 364 (24%) with a (partial) ORF, 188 (12%) that were mappable but without a gene name or an ORF and 7 (0%) that were not mappable

    Interaction network of proteins harboring RCM-associated genetic variants.

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    <p>For proteins with RCM-associated pathogenic and likely pathogenic variants (red boxed), variants of unknown significance (orange boxes) and rare SNPs (yellow boxes) a closely interconnected network was generated by manual curation of scientific literature. The interlinking proteins are shown as gray boxes. Green arrows, red lines with cross bars, green lines with filled circles, and blue lines indicate activation, inhibition, modulation of activity, and direct physical interactions, respectively.</p

    Genetic variants, identified in patients with RCM.

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    <p>(a) Overall yield of genotype-positive (pathogenic and likely pathogenic) variants and variants of unknown significance according to ACMG classification. (b) Genes where pathogenic, likely pathogenic variants and variants of unknown significance were detected. Blue corresponds to the genes encoding for sarcomeric proteins, red—to the genes encoding for cytoskeletal proteins, green—to ion channels and purple to the other genes. (c) Combination of pathogenic variants, likely pathogenic variants and variants of unknown significance in patients with RCMP.</p
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