The age-metallicity relationship in the Fornax spheroidal dwarf galaxy

We produce a comprehensive field star age-metallicity relationship (AMR) from the earliest epoch until ~ 1 Gyr ago for three fields in the Fornax dSph galaxy by using VI photometric data obtained with FORS1 at the VLT. We find that the innermost one does not contains dominant very old stars (age > 12 Gyr), whereas the relatively outer field does not account for representative star field populations younger than ~ 3 Gyr. When focusing on the most prominent stellar populations, we find that the derived AMRs are engraved by the evidence of a outside-in star formation process. The studied fields show bimodal metallicity distributions peaked at [Fe/H] = (-0.95 +- 0.15) dex and (-1.15 or -1.25 +- 0.05) dex, respectively, but only during the first half of the entire galaxy lifetime. Furthermore, the more metal-rich population appears to be more numerous in the outer fields, while in the innermost Fornax field the contribution of both metallicity populations seems to be similar. We also find that the metallicity spread ~ 6 Gyr ago is remarkable large, while the intrinsic metallicity dispersion at ~ 1-2 Gyr results smaller than that for the relatively older generations of stars. We interpret these outcomes as a result of a possible merger of two galaxies that would have triggered a star formation bursting process that peaked between ~ 6 and 9 Gyr ago, depending on the position of the field in the galaxy.Comment: 7 pages, 5 figures, MNRAS, in pres

Representative galaxy age-metallicity relationships

The ongoing surveys of galaxies and those for the next generation of telescopes will demand the execution of high-CPU consuming machine codes for recovering detailed star formation histories (SFHs) and hence age-metallicity relationships (AMRs). We present here an expeditive method which provides quick-look AMRs on the basis of representative ages and metallicities obtained from colour-magnitude diagram (CMD) analyses. We have tested its perfomance by generating synthetic CMDs for a wide variety of galaxy SFHs. The representative AMRs turn out to be reliable down to a magnitude limit with a photometric completeness factor higher than $\sim$ 85 per cent, and trace the chemical evolution history for any stellar population (represented by a mean age and an intrinsic age spread) with a total mass within ~ 40 per cent of the more massive stellar population in the galaxy.Comment: 12 pages, 11 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Neutrophils acROSs the Enemy Lines

In this issue of Immunity, Warnatsch et al. (2017) describe how neutrophils measure their microbial opponents by differential shuttling of reactive oxygen species (ROS), a process that determines their recruitment and distribution and ultimately the strength of anti-microbial responses.S

Leducq Transatlantic Network on Clonal Hematopoiesis and Atherosclerosis

Relevant funding for this work comes from the Leducq Foundation (TNE-18CVD04)

Neutrophils as regulators of the hematopoietic niche

The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche and, ultimately, of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian, and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche.This work was supported in part by SAF2015-65607-R and Fondo Europeo de Desarrollo Regional (FEDER) (A.H.); Ministerio de Ciencia, Innovacion y Universidades (MCIU) for fellowship BES-2014-068915 (I.C.); and R01 HL136529-01 from the National Institutes of Health, National Heart, Lung, and Blood Institute (D.L.). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) was supported by the MCIU and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MCIU award SEV-2015-0505).S

Peripheral inflammatory indexes neutrophil/lymphocyte ratio (NLR) and red cell distribution width (RDW) as prognostic biomarkers in advanced solitary fibrous tumour (SFT) treated with pazopanib

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMPazopanib was assessed prospectively in the GEIS-32 phase II study (NCT02066285) on advanced solitary fibrous tumour (SFT), resulting in a longer progression-free survival (PFS) and overall survival (OS) compared with historical controls treated with chemotherapy. A retrospective analysis of peripheral inflammatory indexes in patients enrolled into GEIS-32 was performed to evaluate their prognostic and predictive value. Patients received pazopanib 800 mg/day as the first antiangiogenic line. The impacts of baseline neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and red cell distribution width (RDW) on PFS, OS, and Choi response were evaluated by univariate and multivariate analysis. Metastasis-free interval (MFI), mitotic count, and ECOG were also included as potential prognostic factors. Sixty-seven SFT patients, enrolled in this study, showed a median age of 63 years and a female/male distribution of 57/43. The median follow-up from treatment initiation was 16.8 months. High baseline NLR, PLR, and standardised RDW were significantly associated with worse PFS and OS. NLR, RDW, MFI, and mitotic count were independent variables for PFS, while RDW and ECOG were independent for OS. Further, NLR and mitotic count were independent factors for Choi response. High baseline NLR and RDW values were independent prognostic biomarkers for worse outcome in advanced SFT patients treated with pazopani

Actualización de la checklist de serpentinófitos suribéricos (Andalucía, España) e implicaciones en su conservación

Resumen de comunicación en CongresoLos ecosistemas serpentínicos son centros de endemización que, por su propia confi guración a modo de islas y los sustratos especiales (peridotitas) , han generado un considerable número tanto de especies endémicas como de taxones ligados en mayor o menor medida a dichos sustratos , así como otros que sufren serpentinomorfosis ( Brooks, R. 1987. Serpentine and its vegetation. A multidisciplinary approach. Dioscorides Press. Portland. ). Contar con un listado actualizado de los taxones ligados a los sustratos serpentínicos con datos sobre su abundancia, distribución y estado de amenaz a es fun damental para la conservación vegetal en dichos ecosistemas. La última revisión data del año 2013 y desde entonces se han descrito nuevos taxones y añadido nuevas poblaciones de serpentinófitos, serpentinófilos y plantas con serpentinomorfosis , lo que obli ga a una puesta al día del listado de dichas plantas. Dicho listado podría combinarse con el propio de los afloramientos serpentínicos galaico -portugueses para configurar un catálogo ibérico.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Reorganización de sociedades

En el presente estudio se analizan los aspectos societarios, contables e impositivos que deben tenerse en cuenta en el proceso de reorganización de sociedades comerciales en Mendoza.Fil: Ávila, Gonzalo . Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Hidalgo, Emmanuel Arian. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Hidalgo, Heber Ignacio. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Masera, Andrés. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: González, Alejandro. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas