Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones

Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones

Open Access Cardiovascular medicine at face value: a qualitative pilot study on clinical axiology

Introduction: Cardiology is characterized by its state-of-the-art biomedical technology and the predominance of Evidence-Based Medicine. This predominance makes it difficult for healthcare professionals to deal with the ethical dilemmas that emerge in this subspecialty. This paper is a first endeavor to empirically investigate the axiological foundations of the healthcare professionals in a cardiology hospital. Our pilot study selected, as the target population, cardiology personnel not only because of their difficult ethical deliberations but also because of th

Bioética en tiempo real: El Límite de la viabilidad en los recién nacidos

Introducción:  los avances en la medicina perinatal en sociedades con mayor desarrollo industrial, han generado reducción en las tasas de mortalidad neonatal con una gradual disminución en la edad gestacional con posibilidades de supervivencia. Objetivo: analizar los elementos bioéticos considerados en la toma de decisiones para establecer los límites de viabilidad en el recién nacido. Metodología: se  realizó una búsqueda bibliográfca en distintas  fuentes  y bases de datos electrónicas  sobre  los  aspectos éticos,  legal  y humanista en relación con el límite de la viabilidad en los recién nacidos. Resultados y conclusiones: se describen dos escenarios clínicos, que son la plataforma para ejemplifcar e  iniciar el análisis del dilema ético que condiciona el  límite de  la viabilidad; se discute  la zona gris de  la neonatología de acuerdo a tasas de sobrevivencia y tasas de mortalidad en distintos países con diferentes características, dividiéndolos en países desarrollados o subdesarrollados. Se realiza el análisis bioético del dilema, en base a las teorías éticas y modelos de discernimiento: teorías utilitarista, deontológica y aretológica. (MÉD UIS.2013;26(3):23-31)Palabras clave: Viabilidad Fetal.  Ética. Recién Nacidos. Prematuros. Bioethics in real time: The limit of viability in newborn infantsABSTRACTAdvances in perinatal medicine over the past decades have led to reduced rates in neonatal mortality with a gradual decrease in gestational age with chances of survival. The aim of this review is to analyze the elements considered in bioethical decision making to establish the limits of viability in the newborn infant. A literature search was conducted in diferent sources and electronic databases on diferent ethics, legal and humanitarian aspects in relation to the limit of neonatal viability. We describe two clinical scenarios, which are the platform to start the analysis of the ethical dilemma that determines the limit of viability. We discuss the “gray zone” of neonatology according to survival and mortality rates in diferent countries with distinctive characteristics, dividing them into developed and developing countries. Bioethical  analysis  is  performed  of  the  dilemma,  based  on  ethical  theories  and models  of  judgment:  utilitarian,  deontological  and aretological theories. (MÉD UIS.2013;26(3):23-31)Key Words: Fetal viability. Ethics. Premature newborns

Respect.

<p>The keywords were identified using the Atlas.ti 6.0 software. The words were sorted according to the frequency of their appearance in the interviews. The cut-off point, which divides the set of words into high-frequency and low-frequency groups, was identified. The graphs explaining the frequency of appearance were created with MS Excel 2007.</p

Today´s medical self and the other: Challenges and evolving solutions for enhanced humanization and quality of care

<div><p>Background</p><p>Recent scientific developments, along with growing awareness of cultural and social diversity, have led to a continuously growing range of available treatment options; however, such developments occasionally lead to an undesirable imbalance between science, technology and humanism in clinical practice. This study explores the understanding and practice of values and value clusters in real-life clinical settings, as well as their role in the humanization of medicine and its institutions. The research focuses on the values of clinical practice as a means of finding ways to enhance the pairing of Evidence-Based Medicine (EBM) with Values-based Medicine (VBM) in daily practice.</p><p>Methods and findings</p><p>The views and representations of clinical practice in 15 pre-CME and 15 post-CME interviews were obtained from a random sampling of active healthcare professionals. These views were then identified and qualitatively analyzed using a three-step hermeneutical approach.</p><p>A <i>clinical values space</i> was identified in which ethical and epistemic values emerge, grow and develop within the biomedical, ethical, and socio-economic dimensions of everyday health care. Three main values—as well as the dynamic clusters and networks that they tend to form—were recognized: healthcare personnel-patient relationships, empathy, and respect. An examination of the interviews suggested that an adequate conceptualization of values leads to the formation of a wider axiological system. The role of <i>clinician-as-consociate</i> emerged as an ideal for achieving medical excellence.</p><p>Conclusions</p><p>By showing the intricate clusters and networks into which values are interwoven, our analysis suggests methods for fine-tuning educational interventions so they can lead to demonstrable changes in attitudes and practices.</p></div

Consociate clinician-patient relationship as cement for the EBM and VBM binomial.

<p>Quotations from interviews illustrating its key aspects.</p