Acrocomia aculeata potential in the Endogenous Development of Cuiabá Region, Brazil

As  condições  edafoclimáticas  propiciam  a  reprodução  da  palmeira  da bocaiuva  (A.  aculeata)na Região Metropolitana do Vale do Rio Cuiabá (RMVRC), e a cultura local de consumo de seu fruto a colocam  como  possível recurso  natural  favorável  ao  processo  de  desenvolvimento  endógeno  da MVRC.  Objetivando  constatar  esta  potencialidade,  foram  estimadas  a população  de A.  aculeatanativas  e  seu  potencial   de  cultivo,  bem  como identificaram-se  os  benefícios  nutritivos  e  as características   químicas   atualmente   explorados   no   principal   centro   consumidor   da   região. Procederam-se entrevistas aos comerciantes da fruta e de seus derivados. Como resultado, tem-se a estimativa de produção anual de 38,7 bilhões de frutos por palmeiras nativas, e de 224,3 bilhões de frutos  anuais  no cultivo. Embora  as  estimativas  apontem  para  a  viabilidade  da exploração, apenas cinco  estabelecimentos  comercializam  a  fruta  e  seus  derivados  em Cuiabá,  indicando  que  a potencialidade da fruta, ainda que existente, não é totalmente explorada.As  condições  edafoclimáticas  propiciam  a  reprodução  da  palmeira  da bocaiuva  (A.  aculeata)na Região Metropolitana do Vale do Rio Cuiabá (RMVRC), e a cultura local de consumo de seu fruto a colocam  como  possível recurso  natural  favorável  ao  processo  de  desenvolvimento  endógeno  da RMVRC.  Objetivando  constatar  esta  potencialidade,  foram  estimadas  a população  de A.  aculeatanativas  e  seu  potencial   de  cultivo,  bem  como identificaram-se  os  benefícios  nutritivos  e  as características   químicas   atualmente   explorados   no   principal   centro   consumidor   da   região. Procederam-se entrevistas aos comerciantes da fruta e de seus derivados. Como resultado, tem-se a estimativa de produção anual de 38,7 bilhões de frutos por palmeiras nativas, e de 224,3 bilhões de frutos  anuais  no cultivo. Embora  as  estimativas  apontem  para  a  viabilidade  da exploração, apenas cinco  estabelecimentos  comercializam  a  fruta  e  seus  derivados  em Cuiabá,  indicando  que  a potencialidade da fruta, ainda que existente, não é totalmente explorada.As  condições  edafoclimáticas  propiciam  a  reprodução  da  palmeira  da bocaiuva  (A.  aculeata)na Região Metropolitana do Vale do Rio Cuiabá (RMVRC), e a cultura local de consumo de seu fruto a colocam  como  possível recurso  natural  favorável  ao  processo  de  desenvolvimento  endógeno  da RMVRC.  Objetivando  constatar  esta  potencialidade,  foram  estimadas  a população  de A.  aculeatanativas  e  seu  potencial   de  cultivo,  bem  como identificaram-se  os  benefícios  nutritivos  e  as características   químicas   atualmente   explorados   no   principal   centro   consumidor   da   região. Procederam-se entrevistas aos comerciantes da fruta e de seus derivados. Como resultado, tem-se a estimativa de produção anual de 38,7 bilhões de frutos por palmeiras nativas, e de 224,3 bilhões de frutos  anuais  no cultivo. Embora  as  estimativas  apontem  para  a  viabilidade  da exploração, apenas cinco  estabelecimentos  comercializam  a  fruta  e  seus  derivados  em Cuiabá,  indicando  que  a potencialidade da fruta, ainda que existente, não é totalmente explorada.The  edaphoclimatic  conditions  favor  the  reproduction  of  the  bocaiuva's palm  (A.  aculeata)  in  the Metropolitan Region of the Cuiabá River Valley (in Portuguese, Região Metropolitana do Vale do Rio Cuiabá -RMVRC),  and  the local  culture  of  consumption  of  its  fruit,place  it  as  a  natural  resource to the process of endogenous development of RMVRC. Aiming to verify this potential, the population of native  A.  aculeata  and  its  cultivation  potential were  estimated,  as  well  as  identifying  the  nutritional benefits  and  the chemical  characteristics  currently  exploited  in  the  main  consumer  center of  the region.  Traders  of  the  fruit  and  its  derivatives  were  interviewed. As  a  result,  there  is  an  estimated annual  production  of  38.7  billion fruits from  native  palms,  and  224.3  billion  annual  fruits  from cultivation. Though  the  estimations  indicate  the  viability  of  the  profiteering,  only five  business establishments trade the fruit and its derivatives in Cuiabá, indicating that the potentiality of the fruit, although existing, is not fully exploited

Potencial da acrocomia aculeata no desenvolvimento endógeno da região de Cuiabá, Brasil

As condições edafoclimáticas propiciam a reprodução da palmeira da bocaiuva (A. aculeata) na Região Metropolitana do Vale do Rio Cuiabá (RMVRC), e a cultura local de consumo de seu fruto a colocam como possível recurso natural favorável ao processo de desenvolvimento endógeno da RMVRC. Objetivando constatar esta potencialidade, foram estimadas a população de A. aculeata nativas e seu potencial de cultivo, bem como identificaram-se os benefícios nutritivos e as características químicas atualmente explorados no principal centro consumidor da região. Procederam-se entrevistas aos comerciantes da fruta e de seus derivados. Como resultado, tem-se a estimativa de produção anual de 38,7 bilhões de frutos por palmeiras nativas, e de 224,3 bilhões de frutos anuais no cultivo. Embora as estimativas apontem para a viabilidade da exploração, apenas cinco estabelecimentos comercializam a fruta e seus derivados em Cuiabá, indicando que a potencialidade da fruta, ainda que existente, não é totalmente explorada.The edaphoclimatic conditions favor the reproduction of the bocaiuva's palm (A. aculeata) in the Metropolitan Region of the Cuiabá River Valley (in Portuguese, Região Metropolitana do Vale do Rio Cuiabá - RMVRC), and the local culture of consumption of its fruit, place it as a natural resource to the process of endogenous development of RMVRC. Aiming to verify this potential, the population of native A. aculeata and its cultivation potential were estimated, as well as identifying the nutritional benefits and the chemical characteristics currently exploited in the main consumer center of the region. Traders of the fruit and its derivatives were interviewed. As a result, there is an estimated annual production of 38.7 billion fruits from native palms, and 224.3 billion annual fruits from cultivation. Though the estimations indicate the viability of the profiteering, only five business establishments trade the fruit and its derivatives in Cuiabá, indicating that the potentiality of the fruit, although existing, is not fully exploited

Abordagem ao paciente pediátrico traumatizado: desafios e atualizações

Para o atendimento de pacientes pediátricos vítimas de trauma, é necessário compreender as principais causas, epidemiologia e fatores de risco. Além disso, é fundamental estar ciente de que acidentes de trânsito, quedas e queimaduras são ocorrências comuns nesse contexto. Vale ressaltar que o trauma representa uma importante causa de morbidade e mortalidade, especialmente entre crianças de 1 a 4 anos. Portanto, garantir um protocolo estruturado e multidisciplinar é essencial para assegurar o melhor cuidado possível

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Potencial da acrocomia aculeata no desenvolvimento endógeno da região de Cuiabá, Brasil

As condições edafoclimáticas propiciam a reprodução da palmeira da bocaiuva (A. aculeata) na Região Metropolitana do Vale do Rio Cuiabá (RMVRC), e a cultura local de consumo de seu fruto a colocam como possível recurso natural favorável ao processo de desenvolvimento endógeno da RMVRC. Objetivando constatar esta potencialidade, foram estimadas a população de A. aculeata nativas e seu potencial de cultivo, bem como identificaram-se os benefícios nutritivos e as características químicas atualmente explorados no principal centro consumidor da região. Procederam-se entrevistas aos comerciantes da fruta e de seus derivados. Como resultado, tem-se a estimativa de produção anual de 38,7 bilhões de frutos por palmeiras nativas, e de 224,3 bilhões de frutos anuais no cultivo. Embora as estimativas apontem para a viabilidade da exploração, apenas cinco estabelecimentos comercializam a fruta e seus derivados em Cuiabá, indicando que a potencialidade da fruta, ainda que existente, não é totalmente explorada.The edaphoclimatic conditions favor the reproduction of the bocaiuva's palm (A. aculeata) in the Metropolitan Region of the Cuiabá River Valley (in Portuguese, Região Metropolitana do Vale do Rio Cuiabá - RMVRC), and the local culture of consumption of its fruit, place it as a natural resource to the process of endogenous development of RMVRC. Aiming to verify this potential, the population of native A. aculeata and its cultivation potential were estimated, as well as identifying the nutritional benefits and the chemical characteristics currently exploited in the main consumer center of the region. Traders of the fruit and its derivatives were interviewed. As a result, there is an estimated annual production of 38.7 billion fruits from native palms, and 224.3 billion annual fruits from cultivation. Though the estimations indicate the viability of the profiteering, only five business establishments trade the fruit and its derivatives in Cuiabá, indicating that the potentiality of the fruit, although existing, is not fully exploited

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

This study identified two phenolic compounds in Schinus terebinthifolius Raddi fruits: naringenin (first report in this species) and gallic acid. Their structures were elucidated by nuclear magnetic resonance (NMR) data (1H-, 13C-NMR) and a high-performance liquid chromatography (HPLC) technique. A high content of phenolics (659.21 mg of gallic acid equivalents/g of sample—Folin-Ciocalteau method) and total flavonoids (140.69 mg of rutin equivalents/g of sample—aluminum chloride method) were quantified in S. terebinthifolius, as well as high antioxidant activity (77.47%—2,2-diphenyl-1-picrylhydrazyl, DPPH method). The antihypertensive activity related to its phenolic content was investigated. After intravenous infusion in Wistar rats, these phenolics significantly reduced (p < 0.05) the systolic, median, and diastolic arterial pressures of individuals. The rotarod test was performed to determine the mechanism of action of the sample vasorelaxant effect. It was found that its action exceeded that of the positive control used (diazepam). This confirmed the vasodilatory activity exerted by S. terebinthifolius fruits is related to the phenolic compounds present in the plant, which are potent antioxidants and inhibit oxidative stress, mainly in the central nervous system

Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae)

Ethnopharmacological relevance: Hyptis Jacq. (Lamiaceae) is being used in traditional medicine to treat fever, inflammation and gastric disturbances. Hyptis spicigera Lam. is a native plant distributed across the central region of Brazil. The essential oil extracted from this plant is used in folk medicine as antipyretic.Aim of the study: The effects of the essential oil obtained from the aerial parts of Hyptis spicigera (OEH) were evaluated for their gastroprotective and healing activities.Materials and methods: OEH chemical composition was analyzed by gas chromatography-mass spectrometry (GC-MS). The gastroprotective action of the OEH was evaluated in rodent experimental models (ethanol and NSAID). To elucidate mechanisms of action, the antisecretory action and involvements of NO, SH, mucus and PGE2 were evaluated. The acetic acid-induced gastric ulcer model and Western Blot assay (COX-2 and EGF) were also used to evaluate the OEH healing capacity.Results: GC-MS analysis of OEH indicated three monoterpenes as major compounds: alpha-pinene (50.8%), cineole (20.3%) and beta-pinene (18.3%) and, at the dose of 100 mg/Kg, p.o., OEH provided effective gastroprotection against lesions induced by absolute ethanol (97%) and NSAID (84%) in rats. OEH do not interfere with H+ secretion in gastric mucosa and its gastric protection does not depend on nitric oxide (NO) and sulfhydryl compounds (SH). The gastroprotective action of OEH occurs due to an increase in the gastric mucus production (28%) induced by PGE2 levels. Furthermore, OEH demonstrated a great healing capacity with 87% of reduction in ulcerative lesion area. It accelerated the healing of acetic acid-induced gastric lesions due to an increase in COX-2 (75%) and EGF (115%) expression in gastric mucosa. No sign of toxicity was observed in this study, considering the analyzed parameters.Conclusions: All these results suggest the efficacy and safety of Hyptis spicigera in combating and healing gastric ulcer. Considering the results, it is suggested that the OEH could probably be a good therapeutic agent for the development of new phytotherapeutic medicine for the treatment of gastric ulcer. (C) 2011 Elsevier B.V. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Imbalance of peripheral temperature, sympathovagal, and cytokine profile in long COVID

Amazon Foundation for Research Support/ (FAPESPA #006/2020 and #060/2020); Secretary of Science, Technology, and Higher, Professional and Technological Education (SECTET #09/2021); Brazilian Council of Scientific and Technological Development Agency (CNPq #401235/2020-3); and Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brasil (INCT: 406360/2022-7).State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil / Federal University of Pará. Tropical Medicine Center. Belém, PA, Brazil / São Paulo University. School of Medicine. São Paulo, SP, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil.Federal University of Pará. Institute of Health Sciences. Belém, PA, Brazil.Federal University of Pará. Institute of Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil / Federal University of Pará. Institute of Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetic of Complex Discasse. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.State University of Pará. Center for Biological Health Sciences. Belém, PA, Brazil / São Paulo University. School of Medicine. São Paulo, SP, Brazil.A persistent state of inflammation has been reported during the COVID-19 pandemic. This study aimed to assess short-term heart rate variability (HRV), peripheral body temperature, and serum cytokine levels in patients with long COVID. We evaluated 202 patients with long COVID symptoms categorized them according to the duration of their COVID symptoms (≤120 days, n = 81; >120 days, n = 121), in addition to 95 healthy individuals selected as controls. All HRV variables differed significantly between the control group and patients with long COVID in the ≤120 days group (p 120 days group in all regions analysed (p < 0.05). Cytokine analysis showed higher levels of interleukin 17 (IL-17) and interleukin 2 (IL-2), and lower levels of interleukin 4 (IL-4) (p < 0.05). Our results suggest a reduction in parasympathetic activation during long COVID and an increase in body temperature due to possible endothelial damage caused by the maintenance of elevated levels of inflammatory mediators. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 appear to constitute a long-term profile of COVID-19 cytokines, and these markers are potential targets for long COVID-treatment and prevention strategies