54 research outputs found

    PENGARUH KETEBALAN SERAT PENGUAT PADA COPV (PVC-COTTON FIBER) TERHADAP KEKUATAN BURST TEST

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    Semakin tingginya tingkat pencemaran udara yang diakibatkan pemakaian bahan bakar minyak (BBM) dan semakin berkurangnya sumber minyak bumi membuat orang mencoba bahan bakar alternatif lain, salah satunya bahan bakar gas (BBG). Salah satu jenis dari bahan bakar gas adalah compressed natural gas (CNG) atau gas alam terkompresi, yaitu gas alam dalam bejana tekan yang dikenai tekanan yang besar. Bejana tekan untuk CNG yang sepenuhnya terbuat dari bahan logam dan harganya relatif murah, namun karena tekanan yang besar membuat resiko tabung meledak sangat besar dan bobot dari tabung tersebut akan sangat berat. Resiko tersebut dapat dikurangi menggunakan pemilihan bejana tekan composite overwrapped pressure vessel (COPV). Composite overwrapped pressure vessel (COPV) merupakan sebuah bejana tekan yang dibalut atau dilapisi oleh serat komposit. COPV biasa digunakan sebagai tempat atau wadah fluida yang memiliki tekanan yang tinggi, seperti oksigen, gas alami terkompresi, gas helium, dan lain sebagainya. Bejana tekan ini terdiri dari dua lapisan, lapisan pertama biasanya terbuat dari logam namun dalam penelitian ini akan menggunakan PVC yang berfungsi mencegah kebocoran, sedangkan lapisan kedua terbuat dari komposit dan dalam penelitian ini menggunakan serat kompositnya yaitu Cotton Fiber yang berfungsi menahan tekanan yang diterima oleh bejana tekan. Dari hasil pengujian yang telah dilakukan dapat disimpulkan bahwa pengaruh serat penguat terhadap tabung PVC sangat berpengaruh sekali yaitu PVC yang telah diberi 1 lapisan cotton fiber kemampuan menahan tekanannya meningkat dari 20 bar menjadi 25 bar. Namun pada 2 lapisan dan 3 lapisan komposit, tekanannya hanya mampu menahan kurang lebih hingga 30 bar saja, dan tegangan yang terjadi semakin banyak lapisan yang digunakan makan tegangan samakin menurun. Kata kunci: COPV (PVC-Cotton Fiber), Hydrotest, Burst Tes

    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (Nature Genetics, (2020), 52, 3, (331-341), 10.1038/s41588-019-0576-7)

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    Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper. The original Article has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper

    Pan-cancer analysis of whole genomes

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    Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
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