Real-World Safety of Anticoagulants

The aim of the present chapter is to characterize the management of anticoagulation in the real-world clinical setting, describing all pharmacological aspects of anticoagulant medications, in particular safety aspects. The chapter is structured into three main sections. Within the first two sections, active principles are classified on the basis of their pharmacological properties (pharmacodynamic and pharmacokinetic characteristic) in old and new molecules (or first and second generation class). In the third one, we discuss safety issues of anticoagulants using available data from postmarketing evidences. Furthermore, we also provide some essential information on the use of this kind of medications in special populations (i.e., elderly, coronary artery disease, diabetics, chronic kidney disease, etc.) in clinical practice

Risk of bone fractures among users of oral anticoagulants: An administrative database cohort study

Occurrence of osteoporotic fracture in patients treated with oral anticoagulants was investigated. •Risk of fractures was comparable for warfarin and non vitamin K oral anticoagulants. •Independently from which OAC is used, female and elderly subjects were at higher risk of fractures