137 research outputs found
The implementation of administrative burden reduction policy: Mechanisms and contexts in the study of Europeanization
Tackling Corruption, Finally? How Domestic and Supranational Factors Have Led to Incremental Policy Change in Italy
Exploring the Dynamics of Delegation Over Time: Insights from Italian Anti-Corruption Agencies (2003-2016)
Resilience Without Resistance: Public Administration Under Mutating Populisms in Office in Italy
The Role of Regulatory Agencies in AgendaâSetting Processes: Insights from the Italian Response to the COVIDâ19 Infodemic
International organizations such as the WHO have worked to raise awareness of the massive infodemic that accompanied the COVIDâ19 outbreak and made it hard for people to find trustworthy sources of information and reliable guidance for their decisions. Our contribution focuses on the Italian case, where the Communications Regulatory Authority (AGCOM) was able to act as first mover in its field so as to strategically frame the problem of disinformation in the absence of a preâexisting policy intervention. An emerging body of research shows that the activity of formally independent regulators is not necessarily limited to the implementation of delegated regulatory competencies. We discuss the implications of the activity of independent regulators for the fight against disinformation during the COVIDâ19 pandemic. We find that as a political actor in its own right, the Italian media regulator claimed control over sectoral expertise in order to shape the crucial first steps of the response to the infodemic
Le politiche di prevenzione della corruzione: la ricerca dellâintegritĂ in assenza di capacitĂ
Forecasting Visitorsâ behaviour in Crowded Museums
In this paper, we tackle the issue of measuring and understanding the visitorsâ dynamics in a crowded museum in order to create and calibrate a predictive mathematical model. The model is then used as a tool to manage, control and optimize the fruition of the museum. Our contribution comes with one successful use case, the Galleria Borghese in Rome, Italy
Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression
Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an essential structural component of cell membranes, is enriched in membrane lipid rafts, and plays a key role in intracellular signal transduction. The lipid homeostasis is finely regulated end appears to be impaired in several types of tumors, including breast cancer. In this review, we will analyse the multifaceted roles of cholesterol and its derivatives in breast cancer progression. As an example of the bivalent role of cholesterol in the cell membrane of cancer cells, on the one hand, it reduces membrane fluidity, which has been associated with a more aggressive tumor phenotype in terms of cell motility and migration, leading to metastasis formation. On the other hand, it makes the membrane less permeable to small water-soluble molecules that would otherwise freely cross, resulting in a loss of chemotherapeutics permeability. Regarding cholesterol derivatives, a lower vitamin D is associated with an increased risk of breast cancer, while steroid hormones, coupled with the overexpression of their receptors, play a crucial role in breast cancer progression. Despite the role of cholesterol and derivatives molecules in breast cancer development is still controversial, the use of cholesterol targeting drugs like statins and zoledronic acid appears as a challenging promising tool for breast cancer treatment
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