5 research outputs found
La teorĂa de la libertad de Hartmann en el contexto de su filosofĂa y en relaciĂłn con la kantiana
Este trabajo pretende exponer la estructura ontolĂłgica fundamental del sistema filosĂłfico de
Nicolai Hartmann desde un punto de vista tanto doxogrĂĄfico como ontolĂłgico, intentando, por
tanto, encontrar temas filosĂłficos entre las exposiciones histĂłricas. De acuerdo con el volumen y la
complejidad de la materia, este trabajo se centra en el problema de la libre voluntad, que es el
fundamento del sistema Ă©tico expuesto por Hartmann en su monumental Ătica y, quizĂĄ, tambiĂ©n el
problema en el que mĂĄs tesis ontolĂłgicas encontramos implicadas. El armazĂłn ontolĂłgico de la obra
de Hartmann y su teorĂa sobre la libertad son tratadas de conectar aquĂ no solo con su contexto
histĂłrico-filosĂłfico, sino tambiĂ©n con todo el sistema de filosofĂa de Hartmann, ya que pretendiĂł la
construcciĂłn de un sistema abarcante, en constante consideraciĂłn de la historia, las ciencias
naturales y sociales y la filosofĂa contemporĂĄnea a Ă©l. De este modo, el sistema filosĂłfico de
Hartmann se pone en relaciĂłn con sus principales raĂces histĂłrico-filosĂłficas, tales como Kant, el
neokantismo, la fenomenologĂa y el aristotelismo y lo mismo sucede con su teorĂa de la libertad, la
cual es comparada con la de Kant y referida a la nociĂłn de valor, la principal en la Ă©tica
fenomenolĂłgica.This work aims to expound the primary ontological framework of Nicolai Hartmannâs
philosophical system both a doxographical and ontological point of view, so it tries to find
philosophical issues in between the historical explanations. Attending to the length and the intricacy
of the matter this work focuses on the free will problem, which is the ground of the ethical system
presented by Hartmann in his huge work Ethics and maybe also it is the problem in which we can
find more ontological thesis involved. Both the general ontological framework of Hartmannâs work
and his theory about liberty are tried to be connected not only with their historical and philosophical
context but also with the whole Hartmannâs system of philosophy because he aimed to develop a
comprehensive one in constant viewing of history, natural and social sciences, and his
contemporary philosophy. So the philosophical system of Hartmann is connected with its main
historical philosophical roots such as Kant and neo-Kantianism, phenomenology and
Aristotelianism and the same holds for his theory of freedom, which is compared with Kantâs one
and referred to the notion of value, the main one in the phenomenological ethics.Universidad de Sevilla. Grado en FilosofĂ
Importancia de la deteccion precoz de terceros molares retenidos en jovenes y adolescentes
Fil: Ledesma, Cristina Andrea. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B; Argentina.Fil: Gilligan, Jorge Marcelo. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B, Argentina.Fil: Ulfohn, AdriĂĄn Gustavo. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B, Argentina.Fil: Bozzatello, Juana Rosa. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: Lehner, Enrique Jorge. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: GarcĂa, Fernando Daniel. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: AlcĂĄzar, Viviana. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra CirugĂa II B; Argentina.Fil: Bonini, Lucas AndrĂ©s. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra CirugĂa II B; Argentina.IntroducciĂłn Proyecto destinado a jĂłvenes alumnos del Instituto La Inmaculada, podrĂĄn ofrecer respuestas innovadoras a las demandas comunitarias. : La retenciĂłn dentaria es un fenĂłmeno frecuente, y su mayor incidencia comprende a la poblaciĂłn adolescente y jĂłvenes. EstadĂsticamente los terceros molares son los elementos dentarios que con mayor frecuencia sufren el fracaso eruptivo, por causas embriolĂłgicas, mecĂĄnicas o sistĂ©micas. Es comĂșn que los jĂłvenes no valoren su salud bucodental, y por ende, esta problemĂĄtica, ya que sus demandas sociales se encaminan hacia otras prioridades. Objetivos: Fomentar la concientizaciĂłn social acerca de la retenciĂłn de terceros molares y desarrollar programas masivos de prevenciĂłn, con participaciĂłn comunitaria integral con fuerte componente preventivo, que garantice impacto en la salud estudiantil, generando espacios integradores entre la Facultad de OdontologĂa y otros niveles educativos. MetodologĂa: La metodologĂa es participativa, con actividades tipo taller y otras modalidades creativas, promoviendo el compromiso de alumnos participantes, estimulados para interactuar entre sus pares y entorno cercano, promoviendo el conocimiento de la retenciĂłn de los terceros molares y sus connotaciones patolĂłgicas. Resultados: Se espera lograr una transformaciĂłn positiva de conductas frente a la retenciĂłn de los terceros molares aspirando a lograr una contribuciĂłn al mejoramiento de su atenciĂłn Conclusiones Se espera concluir en una motivaciĂłn y capacitaciĂłn de los alumnos involucrados suficiente como para actuar como agentes promotores de salud en relaciĂłn a esta problemĂĄtica, transmitiendo sus conocimientos a sus pares y a la comunidad misma.http://www.odo.unc.edu.ar/extension/libro-de-resumenes-i-jornadas-nacionales-de-extension-en-odontologiaFil: Ledesma, Cristina Andrea. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B; Argentina.Fil: Gilligan, Jorge Marcelo. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B, Argentina.Fil: Ulfohn, AdriĂĄn Gustavo. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II B, Argentina.Fil: Bozzatello, Juana Rosa. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: Lehner, Enrique Jorge. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: GarcĂa, Fernando Daniel. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra de CirugĂa II A, Argentina.Fil: AlcĂĄzar, Viviana. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra CirugĂa II B; Argentina.Fil: Bonini, Lucas AndrĂ©s. Universidad Nacional de CĂłrdoba. Facultad de OdontologĂa. CĂĄtedra CirugĂa II B; Argentina.OdontologĂa, Medicina y CirugĂa Ora
El tĂo vivo : textos de lectura secuenciados para primer ciclo de primaria
El profesorado en su tarea de enseñar a leer, tiene que procurarse materiales que contribuyan al desarrollo y afianzamiento de las capacidades lectoras. Con este fin se ofrece un instrumento de trabajo que respeta el nivel lector del alumno a base de textos secuenciados en orden de complejidad para abordar la lectura comprensiva y afianzar la mecånica lectora desde los primeros momentos.ExtremaduraES
Integration of longitudinal deep-radiomics and clinical data improves the prediction of durable benefits to anti-PD-1/PD-L1 immunotherapy in advanced NSCLC patients
Background Identifying predictive non-invasive biomarkers of immunotherapy response is crucial to avoid premature treatment interruptions or ineffective prolongation. Our aim was to develop a non-invasive biomarker for predicting immunotherapy clinical durable benefit, based on the integration of radiomics and clinical data monitored through early anti-PD-1/PD-L1 monoclonal antibodies treatment in patients with advanced non-small cell lung cancer (NSCLC).MethodsIn this study, 264 patients with pathologically confirmed stage IV NSCLC treated with immunotherapy were retrospectively collected from two institutions. The cohort was randomly divided into a training (n = 221) and an independent test set (n = 43), ensuring the balanced availability of baseline and follow-up data for each patient. Clinical data corresponding to the start of treatment was retrieved from electronic patient records, and blood test variables after the first and third cycles of immunotherapy were also collected. Additionally, traditional radiomics and deep-radiomics features were extracted from the primary tumors of the computed tomography (CT) scans before treatment and during patient follow-up. Random Forest was used to implementing baseline and longitudinal models using clinical and radiomics data separately, and then an ensemble model was built integrating both sources of information.ResultsThe integration of longitudinal clinical and deep-radiomics data significantly improved clinical durable benefit prediction at 6 and 9 months after treatment in the independent test set, achieving an area under the receiver operating characteristic curve of 0.824 (95% CI: [0.658,0.953]) and 0.753 (95% CI: [0.549,0.931]). The Kaplan-Meier survival analysis showed that, for both endpoints, the signatures significantly stratified high- and low-risk patients (p-value< 0.05) and were significantly correlated with progression-free survival (PFS6 model: C-index 0.723, p-value = 0.004; PFS9 model: C-index 0.685, p-value = 0.030) and overall survival (PFS6 models: C-index 0.768, p-value = 0.002; PFS9 model: C-index 0.736, p-value = 0.023).ConclusionsIntegrating multidimensional and longitudinal data improved clinical durable benefit prediction to immunotherapy treatment of advanced non-small cell lung cancer patients. The selection of effective treatment and the appropriate evaluation of clinical benefit are important for better managing cancer patients with prolonged survival and preserving quality of life
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease