Bromodomain Inhibitor JQ1 as a Candidate Therapeutic Agent in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare tumor that develops from the mesothelial linings of the pleural, pericardial, and peritoneal cavities. The actual risk factor for developing the disease is exposure to asbestos in workplace. Bromodomain and extraterminal (BET) domain proteins are epigenetic signaling agents that associate with acetylated histones and expedite the transcription of target genes. This study investigates whether the small molecule BET protein inhibitor JQ1 specifically may be an effective therapy for MPM. Reverse transcriptase polymerase chain reaction methods reveal an inclusive change in gene expression implying that JQ1 is a potential inhibitor which targets the BET proteins. Our results report that JQ1 has tumor-suppressive effects as it significantly ceased cellular activity in MPM cell lines. We predict that JQ1 may be the promising therapy for pleural mesothelioma cancers

The Role and Impact of Social Media Influencers

In this paper, we explore the influence of influencers in the digital space and their impact on society. The research involved 375 intentional sampled respondents who are social media followers. The findings revealed that TikTok is the most popular platform for influencers, followed by Instagram, YouTube, Facebook, Snapchat, and Twitter. Influencers predominantly create entertainment and gaming content, with art and skills, social issues, education, and religion following suit. The study highlights that influencers are crucial in shaping societies by providing attractive and concise information and experiences, fostering development and support among their followers. The author suggests enhancing influencers skills through workshops and training programs, focusing on positive interactions, humanitarian aspects, and support for affected sectors, particularly therapeutic institutions

An Analytical Review of the Societal Impacts of the Jordanian

Some radio programs effectively make an impact on individuals and societies. Among the radio programs on the Arab level is the Wast Al-Balad program, which is broadcast on the Jordanian Fan FM radio. The article aimed to provide an analytical reading of the societal sides of the program. The article adopted the qualitative analytical approach using discourse analysis and interview tools. The results showed that the most effective aspect of Wast El Balad program was contributing to solving the social problems of individuals and overcoming difficulties, followed by influencing public opinion and community development. The program focused on the values of helping the needy and addressing societal problems, as well as problems related to government actions. The results also showed that there is a completely harmonious between the vocal and lyrical effects with the topics presented. The interviewees pointed out the programs need for improvement notes for the program, such as diversity, keeping on the current performance, and reducing the advertisements

The Convergence of Traditional Media to the Digital Communicative Environment- The Reality and Gap

The article aimed to reveal the developments that affected the traditional media in response to the digital communication environment, to identify the aspects of employing digital communication, and to address the gap created by the new digital environment compared to the traditional media performance. The qualitative approach was used in addressing the problem of the paper, through the in-depth interviews tool with (8) executives and technicians of six Jordanian media outlets: Radio of the Hashemite Kingdom of Jordan, Rotana Radio, Jordan TV, Amman TV, Al-Rai newspaper, and Al-Ghad newspaper. The article concluded that the most prominent aspects of employing communication digitization in Jordanian media are the preservation of the archive digitally, the creation of a unique application, an earlier manifestation is the creation of a website, and then the opening of accounts on social networks. The results also showed that one of the most essential motivations of digital transformation is reaching ease to the audience with the highest quality, which mobile technology and its applications have enhanced. The form of media sharing of its content on digital platforms and social networks has varied, most notably live broadcasts, publishing news and programs, urgent news, short news stories, video clips, links, infographics, or interviews

Framing the Entrepreneurship in Television Youth Programs An analytical study

The article aimed to identify the contributions of Jordanian TV youth programs in promoting entrepreneurship issues to the youth through content analysis of the youth programs content on the Jordanian TV channels (2021). The study sample was content of; (Jalssah 3alaniyyeh on Almamlaka Tv) and (Rass Btaqiyyeh on Roya TV) during the study year; 2021). The article concluded that the most important results are TV programs focus on the commercial and industrial fields in enhancing the culture of entrepreneurship at youth and other ages. Most of media content topics have been done by producing models and experiences to motivate the public. On the framing, the main ideas, the defining, and the solutions are the most frames depended by TV programs in presenting the entrepreneurship. The TV programs have gotten the information and raw content from TV reporter and correspondent. The researcher recommended to achieve training course for the TV correspondents, presenters, and delegates in the presenting the entrepreneurial programs and using the scientific and planned method to manage the Jordanian TV channels

Strategic information systems planning: A case in the context of United Arab Emirates

Strategic Information Systems Planning (SISP) is increasingly regarded as critical to help business organizations decide their preferences and priorities that are pertinent to IS&T investment, and to ensure that the adoption of such technologies will culminate in tangible business gains and drive value creation for competitive advantages. This study is part of a much wider scoped-research that is concerned with SISP in UAE organizations. The objective of this explorative research is to provide insights on the SISP implementation processes in one of the organizations in the UAE. Future studies would follow to examine multiple organizations and to evaluate the effectiveness of SISP on the organizations performance and to track success factors, strengths weaknesses, processes, methods, techniques, and tools that practitioners are adopting

Data virtualization design model for near real time decision making in business intelligence environment

The main purpose of Business Intelligence (BI) is to focus on supporting an organization‘s strategic, operational and tactical decisions by providing comprehensive, accurate and vivid data to the decision makers. A data warehouse (DW), which is considered as the input for decision making system activities is created through a complex process known as Extract, Transform and Load (ETL). ETL operates at pre-defined times and requires time to process and transfer data. However, providing near real time information to facilitate the data integration in supporting decision making process is a known issue. Inaccessibility to near realtime information could be overcome with Data Virtualization (DV) as it provides unified, abstracted, near real time, and encapsulated view of information for querying. Nevertheless, currently, there are lack of studies on the BI model for developing and managing data in virtual manner that can fulfil the organization needs. Therefore, the main aim of this study is to propose a DV model for near-real time decision making in BI environment. Design science research methodology was adopted to accomplish the research objectives. As a result of this study, a model called Data Virtualization Development Model (DVDeM) is proposed that addresses the phases and components which affect the BI environment. To validate the model, expert reviews and focus group discussions were conducted. A prototype based on the proposed model was also developed, and then implemented in two case studies. Also, an instrument was developed to measure the usability of the prototype in providing near real time data. In total, 60 participants were involved and the findings indicated that 93% of the participants agreed that the DVDeM based prototype was able to provide near real-time data for supporting decision-making process. From the studies, the findings also showed that the majority of the participants (more than 90%) in both of education and business sectors, have affirmed the workability of the DVDeM and the usability of the prototype in particular able to deliver near real-time decision-making data. Findings also indicate theoretical and practical contributions for developers to develop efficient BI applications using DV technique. Also, the mean values for each measurement item are greater than 4 indicating that the respondents agreed with the statement for each measurement item. Meanwhile, it was found that the mean scores for overall usability attributes of DVDeM design model fall under "High" or "Fairly High". Therefore, the results show sufficient indications that by adopting DVDeM model in developing a system, the usability of the produced system is perceived by the majority of respondents as high and is able to support near real time decision making data

Diversity in Harmony: Creating the Built Environment’s Future

The research paper investigates the relationship between the architectural history , innovative design and artifical intelligence ( AI) in shaping the built environment of the future. It investigates architects\u27 ongoing efforts to push past design limitations using AI, with a focus on the expressive capacity of historical architectural materials. It addresses the transformation nature of generative design, emphasizing an iterative process using AI tools. The research paper makes a link between generative design as well as emerging forms of architecture by referencing the Dancism Movement using AI Midjourney tool. A case study demonstrates DANCISM Movement patterns, redefining high-rise buildings by means of a dance-like form, while evaluating AI-generated designs and the resulting educational implications. This investigation incorporates to the ongoing discussion concerning AI\u27s transformation role in developing an extensive as well as dynamic architecture in the years to come

DEVELOPING EMPIRICAL CORRELATION BETWEEN SHEAR WAVE VELOCITY AND STANDARD PENETRATION RESISTANCE USING MASW METHOD

The shear wave velocity (VS) is one of the important parameters that represent the stiffness of the soil layers. The shear wave velocity profile is typically measured by conducting wave propagation tests in the field such as seismic Reflection Test, seismic Refraction Test, suspension logging test, seismic down hole (up hole) test, spectral analysis of surface waves (SASW), Multichannel Analysis of Surface Wave (MASW), etc. But usually it is not economically possible to perform these tests at all the sites. Therefore, a reliable empirical relationship between VS and N-value would be significant advantage; the correlation between N-value and VS can be utilized to evaluate geotechnical parameters in regions where boreholes are not available or geophysical investigation exist. On the other hand, shear wave velocity can be used to estimate several soil parameters through many empirical correlations. In this study, two site investigations for two different sites in Malaysia have been conducted, three SPT test accompanied with MASW test was conducted in first site, while two SPT test and MASW test were conducted in second site. After collecting all the data of SPT and shear wave velocity VS, this study has developed a new relationship between N value and shear wave velocity VS

Artificial Intelligence tools and its role in creating a good E-learning environment

    The descriptive method was used in this study, by creating a questionnaire form using Google Forms, submitted by the faculty and students' communication sites, to answer them online, Results showed that 85% of students in the pure and applied scientific departments prefer online lectures and tests, while 35% of the students in humanitarian sections preferred is not relying on it, and 65% of them preferred to use technology with education.       The study recommends that the adoption of modern technologies in educational systems it increases the comprehension of information during the lectures, through  the presented ways, and following methods that make the student understanding and memorizing more easier , and the  e-learning provides a virtual environment that increases the possibility of communicat  the students with each other , also  between students and professors, it allows the student to access educational materials at any time and anywhere, and helps the teacher to reach his students, inform them of important matters, and send educational materials to them.&nbsp