Synthesis and Spectroscopic Study of Naphtholic and Phenolic Azo Dyes

Azo dyes are extremely important in variety of industries for variety of technical purposes. Hence, a series of naphtholic azo dyes 1-9 were synthesized via diazotization of substituted aniline derivatives followed by azo coupling with 2-naphthol. In similar manner, diazotization followed by azo coupling with phenol afforded phenolic azo dyes 10-17 in excellent yields. The chemical structures of all synthesized compounds were confirmed using analytical data and spectroscopic technique which include Uv-visible, IR, Mass spectra, 1H- and 13C-NMR

Evaluation of antibacterial activity of Pisidium guajava and Gongronema Latifolium

Pisidium guajava and Gongronema latifolium are local plants used traditionally in south-eastern Nigeria to treat ailments such as cough, loss of appetite, malaria and stomach disorders. In this study, aqueous and ethanolic leaf extracts of P. guajava and G. latifolium were screened for antibacterial activity against two clinically isolated organisms of the gastrointestinal tract, Escherichia coli and Staphylococcus aureus. Results obtained show that leaf extracts of both plants possess significant antibacterial activities against the two isolates. Ethanolic extracts showed more inhibitory effect compared to the aqueous extracts. Extracts of P. guajava exhibited higher inhibitory effect than that of G. latifolium. The diameter of zones of inhibition by the leaf extracts of P. guajava was 8 - 16 mm and 14 - 21 mm respectively for the aqueous and ethanolic extracts. The minimum inhibitory concentrations (MICs) were 5.0 and 0.625 mg ml-1 respectively for the aqueous and ethanolic extracts of P. guajava. For the extracts of G. latifolium, the diameter of zones of inhibition was between 6 and 10 mm while MICs were 10.0 and 2.5 mg ml-1 respectively for the aqueous and ethanolic extract

Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N,N-Diethyl Amide Bearing Benzenemethanesulfonamides

An highly expeditious synthetic approach for the synthesis of benzenemethanesulfonamides (1a-k) and their new corresponding N,N-diethyl substituted amido moieties (2a-k) has been achieved in aqueous medium at room tem-perature. The reaction condition was thoroughly optimized thereby allowing significant rate enhancement and resulting into excellent yields. The chemical structures of the successful candidates were confirmed using elemental analytical and spectroscopic data such as IR, 1H NMR, 13C NMR and some selected mass spectral dat