EL DESAFÍO AFRICANO EN EL SIGLO XXI

El autor a través de su experiencia vivida en el continente africano, da sus impresiones de este vasto territorio de nuestro planeta como una nueva frontera que se abre al mundo industrializado. La independencia alcanzada hace apenas 50 años ha traído grandes calamidades; guerras, genocidios, enfermedades, golpes de Estado etc… Sin embargo las riquezas físicas y humanas del continente son una esperanza a mediano plazo para hacer de él una nueva tierra de progreso

Additional file 11: Figure S11. of DeSigN: connecting gene expression with therapeutics for drug repurposing and development

Bosutinib significantly inhibits the proliferation of OSCC cells in dose-dependent manner. OSCC cell lines were treated with bosutinib at 0.3–3 μM for 72 h and the effect of bosutinib on cell proliferation was determined by Click-iT cell proliferation assay. * denotes p-value < 0.05 relative to control untreated cells (0 μM). (TIF 785 kb

Additional file 1: Table S1. of Deep learning of mutation-gene-drug relations from the literature

Feature contribution analysis in our CNN model. Table S2. Results of simple co-occurrence-based method. Table S3. VarDrugPub and OncoKB comparison examples. Figure S1. Precision-Recall curves of our CNN classifier (Blue: Mutation-Gene, Red: Mutation-Drug). (DOCX 50 kb

Additional file 1: Table S1. of Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

IC50 values and SEM for fifty-five colorectal cancer cell lines treated with TAK-960 as assessed by CyQuant proliferation assay. (TIFF 689 kb