Posterior reversible encephalopathy syndrome (PRES) induced by intrathecal methotrexate administration in a patient with acute lymphoblastic leukaemia

A patient with B-cell precursor acute lymphoblastic leukaemia was diagnosed with posterior reversible encephalopathy syndrome (PRES) after an intrathecal administration of methotrexate during induction chemotherapy. PRES presented with headache, epilepsy, unconsciousness, blurred vision, hypertension, and vomiting. Also, characteristic lesions of the central nervous system were revealed by magnetic resonance imaging of the head, especially in the white matter of the posterior lobes

Zespół tylnej odwracalnej encefalopatii wyindukowany dokanałowym podaniem metotreksatu u pacjenta z ostrą białaczką limfoblastyczną

U pacjenta z ostrą białaczką limfoblastyczną o różnicowaniu B-common rozpoznano zespół tylnej odwracalnej encefalopatii (PRES, posterior reversible encephalopathy syndrome) po dokanałowym podaniu metotreksatu w trakcie chemioterapii indukcyjnej. Zespół PRES objawia się bólami głowy, padaczką, zaburzeniami świadomości, zaburzeniami widzenia, nadciśnieniem tętniczym oraz wymiotami. W badaniu rezonansu magnetycznego głowy widoczne są charakterystyczne zmiany w istocie białej mózgu, szczególnie w płatach tylnych

A child with a central nervous system relapse of a facial embryonal rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. There are two main types of RMS: embryonal and alveolar (having a worse prognosis). The treatment for childhood RMS is based on surgery, chemotherapy and radiation. In spite of very intensive therapy, 1/3 of patients suffer a relapse. The case report presents a child with facial embryonal RMS with an atypical central nervous system relapse; this, despite a comprehensive diagnostic process, was diagnosed during the autopsy

Wznowa w obrębie ośrodkowego układu nerwowego u dziecka z rhabdomyosarcoma embryonale twarzoczaszki

Rhabdomyosarcoma (RMS) jest najczęstszym typem mięsaka występującego u dzieci. Rozróżniamy dwa jego główne podtypy: zarodkowy i pęcherzykowy, który wiąże się z gorszym rokowaniem. Leczeniem z wyboru jest radykalny zabieg chirurgiczny, chemioterapia i radioterapia. Pomimo stosowanego leczenia u 1/3 pacjentów dochodzi do wznowy choroby. Niniejsza praca przedstawia nietypowy obraz wznowy w obrębie ośrodkowego układu nerwowego (OUN) u dziewczynki z RMS embryonale twarzoczaszki, która pomimo przeprowadzenia szerokiej diagnostyki została rozpoznana dopiero w badaniu pośmiertnym

The Impact of Modern Ultramarathons on Shaping the Social Identity of Runners. The Case Study of Karkonosze Winter Ultramarathon

Despite the growing interest in extreme sports around the world, researchers have rarely investigated the complex factors that have led to a developed commitment to extreme sports in recent years. Precisely, the social identity of ultramarathoners remains a research niche. The aim of the article is to analyze the impact of a sports event on shaping social identity of ultramarathon runners on the example of Karkonosze Winter Ultramarathon (held in Poland). The qualitative method used in the article—interviews with runners—made it possible to examine the factors that create social identity, among which the motives for participation, sports subculture, and the authenticity of the experience play a key role. The first part of the article describes the theoretical aspects of social identity in sport. The second, empirical part presents the research results supplemented by the statements of the contestants. In this case, the subject of analysis is the motives for participation in a winter ultramarathon and their characteristics. Lastly, the article analyzes the subculture of ultramarathoners and the experience of contestants’ authenticity. The investigated winter ultramarathon created the perfect space for creation, deepening and celebrating the social identity of ultramarathoners assessed as a value in itself. The article enriches the present knowledge about the motivation of ultramarathoners because, unlike the results of quantitative research, it presents in-depth responses of runners who were not always concerned by existing research questionnaires

Annual Observation of Changes in the Angle of Trunk Rotation. Trunk Asymmetry Predictors. A Study from a Scoliosis Screening in School Adolescents

Adolescent forms of idiopathic scoliosis are commonly encountered deformities of the thoracic and lumbar spine. They affect a significant number of adolescents, yet their cause is still unknown. The presented research is a cross-sectional analysis of 3933 volunteers (2131 girls and 1802 boys). The participants were primary school students aged 9 to 13 years old. This study determined a relationship between predictors such as: body mass, body height and body mass index (BMI) (independent variables) and angle of trunk rotation (ATR) value (dependent variable). Moreover, a stepwise multiple regression with backward selection was conducted to determine to what extent the dependent variable is explained by body mass, body height and BMI. In the group of 11,12,13-year-old girls, the analyzed results of multiple stepwise regression were statistically significant. Among the all studied predictors, it has been shown that body mass in the 11-year-old girls and body height in 12- and 13-year-old girls are major correlates of a 1-year ATR increase in proximal and main thoracic spine levels

Anti-PD-1 Therapy in Advanced Pediatric Malignancies in Nationwide Study: Good Outcome in Skin Melanoma and Hodgkin Lymphoma

Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment of childhood cancers is still evolving. The aim of this nationwide retrospective study was to assess the safety and effectiveness of ICIs used in a group of 42 patients, with a median age of 13.6 years, with various types of advanced malignancies treated in pediatric oncology centers in Poland between 2015 and 2023. Results: The indications for treatment with anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); and other malignancies (14). At the end of follow-up, complete remission (CR) was observed in 37.7% (15/42) of children and disease stabilization in 9.5% (4/42), with a mean survival 3.6 (95% CI = 2.6–4.6) years. The best survival (OS = 1.0) was observed in the group of patients with Hodgkin lymphoma. For malignant melanoma of the skin, neuroblastoma, and other rare malignancies, the estimated 3-year OS values were, respectively, 0.78, 0.33, and 0.25 (p = 0.002). The best progression-free survival value (0.78) was observed in the group with malignant melanoma. Significantly better effects of immunotherapy were confirmed in patients ≥ 14 years of age and good overall performance ECOG status. Severe adverse events were observed in 30.9% (13/42) patients