The comparison therapeutic effect of Naltrexone and Flouxetine on Obsessive-Compulsive Disorder (O.C.D) A clinical trial study

Background & Objective: In spit of high prevalancey of the Obsessive-Compulsive Disorder in anxity diseases. It shows the least therapeutic responses. This study was done to determine The comparison of therapeutic effect of Naltrexone and Flouxetine on Obsessive-Compulsive Disorder (O.C.D). Materials & Methods: This double-blind clinical trial study was done on 30 patients aged 18 to 60 years referring to the clinics of psychiatry at Zareh hospital in Sari-Iran during 2006. Patients in three groups, treated with flouxetine 53.9mg/d (group A) Naltrexone 64.4mg/d (groupe B) & Pelacebo (group C) in the same shape capsula respectively. The severity of O.C.D was evaluated at 4 steps with Yale-Brown scale.the obtained data were analyzed using parametric & nonparametric tests. Results: Naltrexone reduced the severity of O.C.D symptoms significantly (45.01%) at the end of week 8th (p<0.05). Same result (45.81%) was observed using Flouxetine (P=0.79). The rate of efficaey in both drugs significantly was higher than pelacebo (P<0.05). Conclusion: This study showed thant, Naltrexone has the same level of reducting symptome of OCD but even with faster therapeutic effect than Flouxetin

Prevalence and Severity of Obsessive-Compulsive Disorder and Their Relationships with Dermatological Diseases

Most obsessive-compulsive disorder (OCD) patients meet psychiatrists 5 to 10 years after onset of OCD .Its relatively high prevalence ratio and the delay in seeking help suggest that patients with OCD may seek help at non-psychiatric clinics. The present study was undertaken to provide some epidemiological data on the prevalence and severity of OCD in dermatological patients. The participants included 265 consecutive patients with primary dermatologic chief complaint. They were visited by a dermatologist and diagnosis of dermatological lesion was done according to ICD-10. All patients were visited by a psychiatry resident and were screened for OCD using the structured clinical interview for DSM-IV-TR (SCID-I). If the diagnosis of OCD has been made, the Yale-Brown obsessive compulsive scale(Y-BOCS) was used to evaluate the severity of OCD. To analyze the data student t-test for quantitative variables and X2 tests for categorical variables. From the total of 265 patients, 24 (9.1%) met the DSM-IV-TR criteria for OCD and 9 (37.5%) with OCD had previously been diagnosed with OCD, however, only three were treated pharmacologically. The most symptoms were pathological doubt (29.1%), fear of contamination (29.1%) and washing (54.16%).  Severity of OCD according to Y-BOCS was evaluated among patients with OCD. Six (25%) were found with subclinical OCD, 11(45.8%) had mild OCD, six (25%) had moderate OCD, and one (4.2%) was detected with severe OCD. prevalence of OCD in dermatology clinic was higher compared with general population

Study on the simultaneity of the substance abuse with psychiatric disorder in referred outpatients to psychiatryclinic of zare hospital for period of one year

(Received 17 Mar, 2008; Accepted 15 Mar, 2008) Abstract Background and purpose: One of the important problems in diagnosis and treatment of psychiatric disorders is its accompaniment with substance abuse.In addition to substance abuse symptoms which are present in all addicts, in psychiatric patients it cause special problems in main diagnosis , slow reaction to therapy and even non effectiveness of the therapy and also poor prognosis.Considering its different prevalence in studies and also considering the point that a similar work has never been done in Iran, this study is designed to find out the abundancy of disorders and pattern and type of substances used by the referred patients to psychiatric clinic of zare hospital.Materials and methods: In this descriptive research study , 782 referrals to psychiatric clinic of zare hospital in a period of one year were evaluated D. S.M. IV interview.The self made Questionnaire which is filed by a psychologist and then referred to a psychiatric for the diagnosis of the disease, includes the time of Commencement, amount and type of substance used.Results: The results obtained, showed that 79.1% were men , 20.9% were women, 54.4% were urban and 45.5% were from rural areas. 4.8% were referred for substance – withdrawal and 95.2% for psychiatry problems. and also the 28% were smokers, 68.4% never smoked and 3.8% were smokers in the past. 12.7% were substance abuse at persent 3.3% had a history if substance abuse in the past and 84% had no history of substance abuse ever. Substance dependency and nondependency were 8.6% and 91.4% respectively. The percentages for the first consumed substance were as follow:60.8 opium, 6.4 alcohal, 26.4 hashish, 4 heroin and 2.4 other substances. From psychiatry diagnostic point of view 28.7% suffered from schizophrenia , 41% had mood disorders, 14% had personality disorders and 4% suffered from anxiety. There has been a statistically significant relationship between the variables such as sex , residential areas , occupation, education, marital status, history of cigarette smoking and age of commence ment of smoking with substance dependency (p<0.05).Conclusion: Considering the high prevalence of Substance usage by the patients referred to psychiatric clinics, the Concurrency of substance usage and psychiatry problems are important in history taking and treatment of the patients. On the other hand to have a high success Coefficient, a simultaneous psychiatric diagnosis for the patients referred for withdrawal , should be kept in mind.J Mazand Univ Med Sci 2008; 18(67): 67-74 (Persian