ROLE OF MICRONUTRIENTS IN HEART DISEASES

Heart disease is a common occurrence in older patients in the civilized culture, and the rate is predicted to rise as the software advances. Patients with heart disease should be intended to eat a salt-free diet to lose adiposity. Diet is also critical for heart disease patients; those with nutrition deficits have a low deep prognosis. A growing body of research indicates a correlation between heart disease and a lack of micronutrients. Repairable heart disease has been linked to thiamine and selenium deficiency. Micronutrients and heart disease may, nevertheless, have a more moderate association, according to recent research. This article looks at studies that looked at micronutrient consumption, supplement effectiveness, and micronutrient ingestion in heart disease patients, with an emphasis on retinol, ascorbic acid, a fat-soluble vitamin, vitamin B1, other B vitamins, cholecalciferol, folate, iron, and copper. Because aging is the leading cause of coronary heart disease, treatments intended to reduce down the aging process or improving life expectancy are distinctly different from their standards for the treatment of coronary heart disease. Altering risky life decisions which might relate to aging and coronary heart diseases, such as nicotine usage, obesity, and unique lifestyles, is increasingly become part of the quality of practice

Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL

Amelioration of Rhabdomyolysis-Induced Myoglobinuric Acute Renal Failure by Citrullus lanatus Seeds

Citrullus lanatus (Thunb.) (Cucerbitaceae) is a trailing annual herb native to India, Nigeria, and Africa, commonly known as Matsum and Nakai. It thrives in all tropical, subtropical, and warm temperate areas with hot summers. In India, seeds have long been used to treat hypotensive and diuretic effects, as well as kidney stones and urinary passages. This study looked at the effects of a methanol extract of C. lanatus seeds (MCL) on rhabdomyolysis-induced myoglobinuric acute renal failure (ARF) in Wistar rats. Five groups (n = 5) of male Albino Wistar rats weighing 150–200 g were formed. A single intramuscular injection of glycerol (GL) (8 ml/kg) was used to induce ARF. Following GL injection, all animals were sacrificed and blood was collected. Renal function tests utilizing blood urea nitrogen (BUN) and creatinine were performed on freshly separated serum. The right kidney was stored in 10% buffered formalin for histological sectioning, and the amount of lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) activity were all measured. The data were analyzed using a one-way ANOVA and Dunnett’s test. *P > 0.05 was considered statistically significant. Animals pre-treated with MCL (100 and 300 mg kg-1, p.o.) for 7 days before GL dramatically altered and restored serum creatinine, BUN, creatinine clearance, urea clearance, and renal morphology in comparison to the GL-treated group. Oxidative stress markers such as lipid peroxidation, SOD, CAT, and GSH were also dramatically improved. The findings of this study suggest that C. lanatus seed has a possible anti-GL-induced ARF effect, verifying its ethnomedicinal use

Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

994-998Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL